BibTex RIS Cite

Comparison of uterin artery doppler indices, endometrial thickness and histopathological findings of symptomatic and asymptomatic postmenopausal women

Year 2008, Volume: 39 Issue: 4, 167 - 173, 01.05.2008

Abstract

Objective: In this study we aimed to demonstrate the utility of Doppler Ultrasound (USG) as a screening tool by means of defining the sensitivity and specificity of Doppler USG findings and endometrial thickness in determining endometrial pathologies in postmenopausal women. Plan: Prospective Cohort Patients: 57 women with postmenopausal bleeding and 57 control women without postmenopausal bleeding. None of them received hormon replacement therapy. Tests: Doppler USG, Endometrial sampling Evaluation: Endometrial thickness and uterine artery Doppler indices were defined prior to endometrial sampling. Histopathological findings were compared with endometrial thickness and uterine artery RI and PI values. A p value of less than 0.05 was considered significant with a confidence interval of 95 %. Results: Sensitivity and specificity of endometrial thickness in (acceptedcut-off5.5 mm) determining endometrial pathologies were found to be % 76 and % 52. Sensitivity and specificity of uterine artery Doppler indices in determining endometrial pathologies were calculated alternately; right RI: 100%- 30%, leftRI: 83%- 52%, right PI: 100%-22%, left PI: 83%- 26%. Comment: Sensitivity and specificity of uterine artery Doppler indices in determining endometrial pathologies is significantly higher than sensitivity and specificity of endometrial thickness.

References

  • 1.Fleischer; Manning; Jeanty; Romero :Sonography in Obstetrics and Gynecology 1996 P:852 2.Holst J, Koskela O, von Schoultz B. Endometrial findings following curettage in 2018 women according to age and indications.Ann Chir Gynecol. 1983;72; 274-277
  • 3.Mac Kenzie I,Bibby J. Critical assessment of dilatation and curettage in 1029 women.Lancet. 197 8;2; 566-568 4.Lidor A,İsmajovich B,Confino E, et al.Histopathological findings in 226 women with postmenopausal bleeding.Acta Obstet Gynecol Scand 1986;65:41-43 5.Nasri M, Coast G. Correlation of ultrasound findings and endometrial histopathology in postmenopausal women .Br J Obstet Gynecol 1989;96:1333-1338
  • 6.Granberg S, Wikland M,Karlsson B,Norstrom A,Friberg LG.Endometrial thickness as measured by endovajinal ultrasonography for identifiying endometrial abnormality.Am J Obstet Gynecol 1991:164:47-52 7.Grimes DA.Diagnostic dilatation and curettage:A reappraisal. Am J Obstet Gynecol 1982:142:1-6 8.Karlsson B, Granberg S., Wikland M., Ylötalo P et al. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding- A Nordic multicenter study. Am J Obstet Gynecol 1995;172:1488-1494 9.Dorum A. G ,Kristensen A,Langebrekke T, Sornes and Skaar O..Evaluation of endometrial thickness measured by endovaginal ultrasound in women with postmenopausal bleeding. Ada Obstet Gynecol Scand. 1993;72:116-119 10.Granberg S, Wikland M,Karlsson B,Norstrom A,Friberg LG.Endometrial thickness as measured by endovajinal ultrasonography for identifıying endometrial abnormality.Am J Obstet Gynecol 1991;164:47-52 11.Vuento M, Pirhonen J.P., Makinen J.I. et al.Screening for endometrial cancer in asymptomatic postmenopausal women with conventional and color Doppler sonography.Br J Obstet Gynecol Janl999; 106:14-20 12.Choo Y.C., Mak K.C., Hsu C. et al.Postmenopausal uterine bleeding of non-organic cause.Obstet Gynecol 1985;66:225 13.Gredmark T, Kvint S, Havel G,et al.Histopathological findings in women with postmenopausal bleeding. Br J Obstet Gynecol 1995 Feb;102(2):133-136 14.Iatrakis G,Diakakis I,Kourounis G,Sakellaropoulos G et al.Postmenopausal bleeding.ClinExp Obstet Gynecol 1997;24(3): 157 15.Gull B., Carlsson S.B., Karlsson B, Ylöstalo P. Transvaginal. ultrasonography of the endometnum in women with postmenopausal bleeding:ls it always necessary to perform endometrial biopsy?Am J Obstet Gynecol 2000 ;182:509-515 16.Smith-Bindman R, Kerlikowske K, Feldstein V.A., SubakL. et al.Endovaginal Ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 1998;280:1510-1517 17.Nasri MN, Coast GJ. Correlation of ultrasound findings and endometrial histopathology in postmenopausal women .Br J Obstet Gynecol 1989;96:1333-1338 18.Chambers CB, Unis JS. Ultrasonic evidence of uterine malignency in postmenopausal uterus. Am J Obstet Gynecol 1986:154:1194-1199 19.Osmers R,Volksen M,Shauer A. Vaginosonography for ealy detection of endometrial carsinoma . Lancet 1990 ;1:1569-1571 20.Weiner Z, Beck D, Rottem S, Branders J.M. et. al. Uterine artery flow velocity waveforms and color flow imaging in women with perimenopausal and postmenopausal bleeding.Correlation to endometrial histopathology.Ada Obstet Gynecol Scand.l993;72:162-166 21.Nasri MN,Shepherd JH,Setchell ME,Lowe DG,Chard T.Sonographic depiction of postmenopausal endometrium with transabdominal and transvaginal scanning. Ultrasound Obstet Gynecol 1991;1:279-283 22.Nasri MN, Shepherd JH,Setchell ME,Lowe DG, Chard. The role of vaginal scan in measurment of endometrial thickness in postmenopausal women. Br J Obstet Gynecol 1991:98:470-475 23.Varner RE, Sparks JM; Cameron CD-Roberts LL;Soong SJ. Transvaginal sonography of the endometrium in postmenopausal women. Obstet Gynecol 1991:78:195-199 24.Amit A, Weiner Z, Ganem N, Kemer H, Edwards C.L., Kaplan A, Beck D. The diagnostic value of color Doppler measurments in the endometrium of women with postmenopausal bleeding. Gynecologic Oncology.2000; 77;243-247 25.Kurjak A,Zalud I, Alfirevic D and Jurkovic D.The assessment of abnormal pelvic blood flow by transvaginal color Doppler. Ultrasound Med Biol.1990; 16:437-442 26.Kurjak A, Shalan H, Sosic A, Benic A et al.Endometrial carsinoma in postmenopausal women Evaluation by transvaginal color Doppler ultrasonography. Am J Obstet Gynecol 1993:169:1597-1603 27.Sladkavicues P, Valantin L., Mar sal KEndometrial thickness and Doppler velocimetry of the uterine atreies as discriminators of endometrial status in women with postmenopausal bleeding. Am J Obstet Gynecol 1994; 171:722-728

Postmenopozal semptomatik ve asemtomatik olgularda uterin arter doppler indeks, endometrial kalınlık ve histopatolojik bulguların karşılaştırılması

Year 2008, Volume: 39 Issue: 4, 167 - 173, 01.05.2008

Abstract

Objektif: Bu çalışmamızda, PMK'lı olgularda Doppler USG bulguları ve endometrium kalınlığının, endometrial patolojileri saptamadaki sensitivite ve spesifisitesini belirleyerek, Doppler USG nin bir tarama yöntemi olarak kullanılabilirliğini göstermeyi amaçladık. Planlama : Pro sp ektif Kohort Hastalar: Hormon replasman tedavisi almayan postmenopozal kanaması olan 57 olgu ve kontrol grubunu oluşturan postmenopozal kanaması olmayan 57 olgu. Girişim: Doppler Ultrasonografı, Endometrial Örnekleme. Değerlendirme: Endometrial örnekleme öncesi, endometrium kalınlıkları ve uterin arter doppler indeksleri belirlendi. Histo-patolojik bulgular ile endometrium kalınlığı ve uterin arter RI ve PI değerleri karşılaştırıldı. Sonuçlar %95'likgüven aralığında,p

References

  • 1.Fleischer; Manning; Jeanty; Romero :Sonography in Obstetrics and Gynecology 1996 P:852 2.Holst J, Koskela O, von Schoultz B. Endometrial findings following curettage in 2018 women according to age and indications.Ann Chir Gynecol. 1983;72; 274-277
  • 3.Mac Kenzie I,Bibby J. Critical assessment of dilatation and curettage in 1029 women.Lancet. 197 8;2; 566-568 4.Lidor A,İsmajovich B,Confino E, et al.Histopathological findings in 226 women with postmenopausal bleeding.Acta Obstet Gynecol Scand 1986;65:41-43 5.Nasri M, Coast G. Correlation of ultrasound findings and endometrial histopathology in postmenopausal women .Br J Obstet Gynecol 1989;96:1333-1338
  • 6.Granberg S, Wikland M,Karlsson B,Norstrom A,Friberg LG.Endometrial thickness as measured by endovajinal ultrasonography for identifiying endometrial abnormality.Am J Obstet Gynecol 1991:164:47-52 7.Grimes DA.Diagnostic dilatation and curettage:A reappraisal. Am J Obstet Gynecol 1982:142:1-6 8.Karlsson B, Granberg S., Wikland M., Ylötalo P et al. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding- A Nordic multicenter study. Am J Obstet Gynecol 1995;172:1488-1494 9.Dorum A. G ,Kristensen A,Langebrekke T, Sornes and Skaar O..Evaluation of endometrial thickness measured by endovaginal ultrasound in women with postmenopausal bleeding. Ada Obstet Gynecol Scand. 1993;72:116-119 10.Granberg S, Wikland M,Karlsson B,Norstrom A,Friberg LG.Endometrial thickness as measured by endovajinal ultrasonography for identifıying endometrial abnormality.Am J Obstet Gynecol 1991;164:47-52 11.Vuento M, Pirhonen J.P., Makinen J.I. et al.Screening for endometrial cancer in asymptomatic postmenopausal women with conventional and color Doppler sonography.Br J Obstet Gynecol Janl999; 106:14-20 12.Choo Y.C., Mak K.C., Hsu C. et al.Postmenopausal uterine bleeding of non-organic cause.Obstet Gynecol 1985;66:225 13.Gredmark T, Kvint S, Havel G,et al.Histopathological findings in women with postmenopausal bleeding. Br J Obstet Gynecol 1995 Feb;102(2):133-136 14.Iatrakis G,Diakakis I,Kourounis G,Sakellaropoulos G et al.Postmenopausal bleeding.ClinExp Obstet Gynecol 1997;24(3): 157 15.Gull B., Carlsson S.B., Karlsson B, Ylöstalo P. Transvaginal. ultrasonography of the endometnum in women with postmenopausal bleeding:ls it always necessary to perform endometrial biopsy?Am J Obstet Gynecol 2000 ;182:509-515 16.Smith-Bindman R, Kerlikowske K, Feldstein V.A., SubakL. et al.Endovaginal Ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 1998;280:1510-1517 17.Nasri MN, Coast GJ. Correlation of ultrasound findings and endometrial histopathology in postmenopausal women .Br J Obstet Gynecol 1989;96:1333-1338 18.Chambers CB, Unis JS. Ultrasonic evidence of uterine malignency in postmenopausal uterus. Am J Obstet Gynecol 1986:154:1194-1199 19.Osmers R,Volksen M,Shauer A. Vaginosonography for ealy detection of endometrial carsinoma . Lancet 1990 ;1:1569-1571 20.Weiner Z, Beck D, Rottem S, Branders J.M. et. al. Uterine artery flow velocity waveforms and color flow imaging in women with perimenopausal and postmenopausal bleeding.Correlation to endometrial histopathology.Ada Obstet Gynecol Scand.l993;72:162-166 21.Nasri MN,Shepherd JH,Setchell ME,Lowe DG,Chard T.Sonographic depiction of postmenopausal endometrium with transabdominal and transvaginal scanning. Ultrasound Obstet Gynecol 1991;1:279-283 22.Nasri MN, Shepherd JH,Setchell ME,Lowe DG, Chard. The role of vaginal scan in measurment of endometrial thickness in postmenopausal women. Br J Obstet Gynecol 1991:98:470-475 23.Varner RE, Sparks JM; Cameron CD-Roberts LL;Soong SJ. Transvaginal sonography of the endometrium in postmenopausal women. Obstet Gynecol 1991:78:195-199 24.Amit A, Weiner Z, Ganem N, Kemer H, Edwards C.L., Kaplan A, Beck D. The diagnostic value of color Doppler measurments in the endometrium of women with postmenopausal bleeding. Gynecologic Oncology.2000; 77;243-247 25.Kurjak A,Zalud I, Alfirevic D and Jurkovic D.The assessment of abnormal pelvic blood flow by transvaginal color Doppler. Ultrasound Med Biol.1990; 16:437-442 26.Kurjak A, Shalan H, Sosic A, Benic A et al.Endometrial carsinoma in postmenopausal women Evaluation by transvaginal color Doppler ultrasonography. Am J Obstet Gynecol 1993:169:1597-1603 27.Sladkavicues P, Valantin L., Mar sal KEndometrial thickness and Doppler velocimetry of the uterine atreies as discriminators of endometrial status in women with postmenopausal bleeding. Am J Obstet Gynecol 1994; 171:722-728
There are 3 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Barış Mülayim This is me

Zeki Şahinoğlu This is me

Sema Mülayim This is me

Habibe Ayvacı This is me

Umur Kuyumcuoğlu This is me

Publication Date May 1, 2008
Published in Issue Year 2008 Volume: 39 Issue: 4

Cite

APA Mülayim, B., Şahinoğlu, Z., Mülayim, S., Ayvacı, H., et al. (2008). Postmenopozal semptomatik ve asemtomatik olgularda uterin arter doppler indeks, endometrial kalınlık ve histopatolojik bulguların karşılaştırılması. Zeynep Kamil Tıp Bülteni, 39(4), 167-173. https://doi.org/10.16948/zktb.55945
AMA Mülayim B, Şahinoğlu Z, Mülayim S, Ayvacı H, Kuyumcuoğlu U. Postmenopozal semptomatik ve asemtomatik olgularda uterin arter doppler indeks, endometrial kalınlık ve histopatolojik bulguların karşılaştırılması. Zeynep Kamil Tıp Bülteni. May 2008;39(4):167-173. doi:10.16948/zktb.55945
Chicago Mülayim, Barış, Zeki Şahinoğlu, Sema Mülayim, Habibe Ayvacı, and Umur Kuyumcuoğlu. “Postmenopozal Semptomatik Ve Asemtomatik Olgularda Uterin Arter Doppler Indeks, Endometrial kalınlık Ve Histopatolojik bulguların karşılaştırılması”. Zeynep Kamil Tıp Bülteni 39, no. 4 (May 2008): 167-73. https://doi.org/10.16948/zktb.55945.
EndNote Mülayim B, Şahinoğlu Z, Mülayim S, Ayvacı H, Kuyumcuoğlu U (May 1, 2008) Postmenopozal semptomatik ve asemtomatik olgularda uterin arter doppler indeks, endometrial kalınlık ve histopatolojik bulguların karşılaştırılması. Zeynep Kamil Tıp Bülteni 39 4 167–173.
IEEE B. Mülayim, Z. Şahinoğlu, S. Mülayim, H. Ayvacı, and U. Kuyumcuoğlu, “Postmenopozal semptomatik ve asemtomatik olgularda uterin arter doppler indeks, endometrial kalınlık ve histopatolojik bulguların karşılaştırılması”, Zeynep Kamil Tıp Bülteni, vol. 39, no. 4, pp. 167–173, 2008, doi: 10.16948/zktb.55945.
ISNAD Mülayim, Barış et al. “Postmenopozal Semptomatik Ve Asemtomatik Olgularda Uterin Arter Doppler Indeks, Endometrial kalınlık Ve Histopatolojik bulguların karşılaştırılması”. Zeynep Kamil Tıp Bülteni 39/4 (May 2008), 167-173. https://doi.org/10.16948/zktb.55945.
JAMA Mülayim B, Şahinoğlu Z, Mülayim S, Ayvacı H, Kuyumcuoğlu U. Postmenopozal semptomatik ve asemtomatik olgularda uterin arter doppler indeks, endometrial kalınlık ve histopatolojik bulguların karşılaştırılması. Zeynep Kamil Tıp Bülteni. 2008;39:167–173.
MLA Mülayim, Barış et al. “Postmenopozal Semptomatik Ve Asemtomatik Olgularda Uterin Arter Doppler Indeks, Endometrial kalınlık Ve Histopatolojik bulguların karşılaştırılması”. Zeynep Kamil Tıp Bülteni, vol. 39, no. 4, 2008, pp. 167-73, doi:10.16948/zktb.55945.
Vancouver Mülayim B, Şahinoğlu Z, Mülayim S, Ayvacı H, Kuyumcuoğlu U. Postmenopozal semptomatik ve asemtomatik olgularda uterin arter doppler indeks, endometrial kalınlık ve histopatolojik bulguların karşılaştırılması. Zeynep Kamil Tıp Bülteni. 2008;39(4):167-73.