Histolojik koioamnionitin erken doğum üzerindeki etkisi

Oya Demirci; Özlem Bozoklu; Elif Demirci; Semih Tuğrul; Ayşe Gürbüz; Sadiye Eren; Handan Çetiner

doi:10.16948/zktb.54444

Histologic chorioamnionitis and preterm delivery

Year 2010, Volume: 41 Issue: 2, 59 - 63, 01.03.2010

Oya Demirci Özlem Bozoklu Elif Demirci Semih Tuğrul Ayşe Gürbüz Sadiye Eren Handan Çetiner

Abstract

Objective: To determine the effects of histological chorioamnionitis in preterm delivery and to investigate the other causes. Material and Methods: The study group consisted of 65 preterm and 71 term pregnancies who are singleton, in active labor and without rupture of membranes. The patients were questioned about their obstetric history, and blood, urine sample for laboratory analysis and vaginal culture were obtained. All placentas were evaluated histopathologically and searched for histological chorioamnionitis. Results: In 2 (3.1%) of 65 preterm labors and 1 (%1.4) of 71 term labors, histological chorioamnionitis was detected. In terms of histological chorioamnionitis, there was no statistical difference between the groups (p>0.05). Also, in terms of history of previous cesarean section, gestational diabetes mellitus and history of urinary tract infection, statistically significant difference were present between preterm and term groups (p=0.007, 0.043, 0.04). Conclusion: The result of our study does not show the relationship between histological chorioamnionitis and preterm delivery. It might be due to the small size of our sample group. Therefore, a better understanding of the presence of histological chorioamnionitis on preterm delivery, there is requirement of longdated several studies.

Keywords

References

1. Lettieri L, Vintzileos AM, Rodis JF, Albini SM, Salafia CM. Does idiopathic preterm labor resulting in preterm birth exist? AmJObstet Gynecol 1993; 168:1480-5
2. Hack M, Fanaroff A A. Outcomes of extremely immature infants-a perinatal dilemma. N Engl J Med 1985; 312:82-90
3.Rush RW, Keirse MJNC, Howat P, Baum JD, Andersen ABM, Turnbull AC. Contribution of preterm delivery to perinatal mortality.Br Med J 1976-2 : 965-8
4. Gibbs RS, Romeo R, Hillier SL, Eschenbach DA, Sweet RL.A review of premature birth and subclinical infection.Am J Obstet Gynecol 1992;166:1515-28
5. MinkojfH. Prematurity: infection as an etiologic factor. Obstet Gynecol 1983;62: 137-44
6. Hillier SL, Martius J, Krohn MA, Kiviat NB, Holmes KK, Eschenbach DA.A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity. N Engl J Med 1988; 319:972-8
7. Aquino TI, Zhang J, Kraus FT, Knefel R, Taff T. Subchorionic fibrin cultures for bacteriologic study of the placenta. Am J Clin Pathol 1984; 81:482-6
8. Svensson L, Ingermarsson I, Mardh PA.Chorioamnionitis and the isolation of microorganisms from the placenta. Obstet Gynecol 1986; 67: 403-9
9. Larson JF, Eldon K, Lange AP, et al. Ritodrine in the treatment of preterm labor: second Danish multicenter study.Obstet Gynecol 1986; 67: 607-13
10. Ballard J, Novak KK, Driver M.A simplified score for assessment of fetal maturation of newly born infants.J Pediatr 1979; 95: 769-74
11. Salafia CM, Weigl C, SilbermanL.Theprevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol 1989; 73:383-98
12. Romero R, Sirtori M, Oyarzun E, et al.Infection and labor. V. Prevalance, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989; 161:817-24
13.Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel L, Hassan S.The role of inflamation and infection in preterm birth. Semin Reprod Med2007; 25:21-39
14. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel LA, Nien JK.Inflammtion in preterm and term labour and delivery. Seminars in Fetal and Neonatal Medicine 2006; 11: 317-26
15. DujfP, Kopelman JN.Subclinical intra-amniotic infection in asymptomatic patients with refractory preterm labor. Obstet Gynecol 1987; 69: 756-9
16. Guzick DS, Winn K.The association of chorioamnionitis with preterm delivery. Obstet Gynecol 1985; 65:11-6
17. Hillier SL, Krohn MA, Kiviat NB, Watts DH, Eschenbach DA. Microbiologic causes and neonatal outcomes associated with choriamnion infection.Am J Obstet Gynecol. 1991; 165:955-61
18. Mays JK, Figueroa R, Shah J, Khakoo H, Kaminsky S, Tejani N. Amniocentesis for selection bfore rescue cerclage. Obstet Gynecol 2000; 95:652
19. Romero R, Gonzalez R, Sepulveda W, Brandt F, Ramirez M, Sorokin Y, Mazor M, Treadwell MC, Cotton DB. Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. Am J Obstet Gynecol. 1992 ;167:1086-91
20. Gray DJ, Robinson HB, Malone J, Thomson RB Jr. Adverse outcome in pregnancy following amniotic fluid isolation ofUreoplasma urealyticum
21. Abu Hamad Kh, Abed Y, Abu Hamad B. Risk factors associated with preterm birth in the Gaza Strip: hospital-based case-control study. East Mediterr Health J 2007; 13:1132-41
22. Covarrubias LO, Aguirre GE, Chapuz JR, May AI, Velazquez JD, Eguiluz ME Maternal factors associated to prematurity Ginecol Obstet Mex. 2008; 76:526-36
23. McDonald HM, Brocklehurst P, Gordon A. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev. 2007; 24.CD000262
24. SimcoxR, Sin WT, Seed PT, Briley A, Shennan AH. Prophylactic antibiotics for the prevention of preterm birth in women at risk: a meta-analysis. Aust N ZJ Obstet Gynaecol 2007; 47:368-77

Histolojik koioamnionitin erken doğum üzerindeki etkisi

Year 2010, Volume: 41 Issue: 2, 59 - 63, 01.03.2010

Oya Demirci Özlem Bozoklu Elif Demirci Semih Tuğrul Ayşe Gürbüz Sadiye Eren Handan Çetiner

Abstract

Amaç: Histolojik korioamniorıitin erken doğum üzerindeki etkisini ve erken doğumu etkileyen diğer faktörleri araştırmak amaçlanmıştır.. Yöntem: Çalışmada aktif eylemde olan , erken membrane rupture olmayan ve tekil gebelikleri içeren 65 preterm ve 71 term gebelerden alınan plasentalar histopatolojik olarak incelenmiştir. Bunun yanında tüm hastalardan obstetric anamnez, kan, idrar ve vajinal kültür örnekleri alınarak olası etiyolojik faktörler araştırılmıştır. Bulgular: Plasentaların histopatolojik olarak incelenmesi sonrası preterm doğumlar içerisinde 2 (3.1%), term doğumlar içerisinde 1 (%1.4) oranında histolojik korioamnit saptanmıştır. Geçirilmiş sezaryen doğum öyküsü, bu gebeliğinde saptanan gestasyonel diyabet ve idrar yolu enfeksiyonu hikayesi pretem doğum yapan gebelerde istatiksel anlamlı olarak daha yüksek bulunmuştur. Sonuç: Bu çalışmanın sonucunda histolojik koryoamniyonit ve preterm doğum ilişkisi koryoamniyonit vakalarının sayıca yetersiz olmasından dolayı söylenemez.Bu nedenle bu konuda daha fazla sayıda ve uzun süreli çalışmalara ihtiyaç vardır.

Keywords

References

1. Lettieri L, Vintzileos AM, Rodis JF, Albini SM, Salafia CM. Does idiopathic preterm labor resulting in preterm birth exist? AmJObstet Gynecol 1993; 168:1480-5
2. Hack M, Fanaroff A A. Outcomes of extremely immature infants-a perinatal dilemma. N Engl J Med 1985; 312:82-90
3.Rush RW, Keirse MJNC, Howat P, Baum JD, Andersen ABM, Turnbull AC. Contribution of preterm delivery to perinatal mortality.Br Med J 1976-2 : 965-8
4. Gibbs RS, Romeo R, Hillier SL, Eschenbach DA, Sweet RL.A review of premature birth and subclinical infection.Am J Obstet Gynecol 1992;166:1515-28
5. MinkojfH. Prematurity: infection as an etiologic factor. Obstet Gynecol 1983;62: 137-44
6. Hillier SL, Martius J, Krohn MA, Kiviat NB, Holmes KK, Eschenbach DA.A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity. N Engl J Med 1988; 319:972-8
7. Aquino TI, Zhang J, Kraus FT, Knefel R, Taff T. Subchorionic fibrin cultures for bacteriologic study of the placenta. Am J Clin Pathol 1984; 81:482-6
8. Svensson L, Ingermarsson I, Mardh PA.Chorioamnionitis and the isolation of microorganisms from the placenta. Obstet Gynecol 1986; 67: 403-9
9. Larson JF, Eldon K, Lange AP, et al. Ritodrine in the treatment of preterm labor: second Danish multicenter study.Obstet Gynecol 1986; 67: 607-13
10. Ballard J, Novak KK, Driver M.A simplified score for assessment of fetal maturation of newly born infants.J Pediatr 1979; 95: 769-74
11. Salafia CM, Weigl C, SilbermanL.Theprevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol 1989; 73:383-98
12. Romero R, Sirtori M, Oyarzun E, et al.Infection and labor. V. Prevalance, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989; 161:817-24
13.Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel L, Hassan S.The role of inflamation and infection in preterm birth. Semin Reprod Med2007; 25:21-39
14. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel LA, Nien JK.Inflammtion in preterm and term labour and delivery. Seminars in Fetal and Neonatal Medicine 2006; 11: 317-26
15. DujfP, Kopelman JN.Subclinical intra-amniotic infection in asymptomatic patients with refractory preterm labor. Obstet Gynecol 1987; 69: 756-9
16. Guzick DS, Winn K.The association of chorioamnionitis with preterm delivery. Obstet Gynecol 1985; 65:11-6
17. Hillier SL, Krohn MA, Kiviat NB, Watts DH, Eschenbach DA. Microbiologic causes and neonatal outcomes associated with choriamnion infection.Am J Obstet Gynecol. 1991; 165:955-61
18. Mays JK, Figueroa R, Shah J, Khakoo H, Kaminsky S, Tejani N. Amniocentesis for selection bfore rescue cerclage. Obstet Gynecol 2000; 95:652
19. Romero R, Gonzalez R, Sepulveda W, Brandt F, Ramirez M, Sorokin Y, Mazor M, Treadwell MC, Cotton DB. Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. Am J Obstet Gynecol. 1992 ;167:1086-91
20. Gray DJ, Robinson HB, Malone J, Thomson RB Jr. Adverse outcome in pregnancy following amniotic fluid isolation ofUreoplasma urealyticum
21. Abu Hamad Kh, Abed Y, Abu Hamad B. Risk factors associated with preterm birth in the Gaza Strip: hospital-based case-control study. East Mediterr Health J 2007; 13:1132-41
22. Covarrubias LO, Aguirre GE, Chapuz JR, May AI, Velazquez JD, Eguiluz ME Maternal factors associated to prematurity Ginecol Obstet Mex. 2008; 76:526-36
23. McDonald HM, Brocklehurst P, Gordon A. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev. 2007; 24.CD000262
24. SimcoxR, Sin WT, Seed PT, Briley A, Shennan AH. Prophylactic antibiotics for the prevention of preterm birth in women at risk: a meta-analysis. Aust N ZJ Obstet Gynaecol 2007; 47:368-77

There are 24 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Oya Demirci This is me Özlem Bozoklu This is me Elif Demirci This is me Semih Tuğrul This is me Ayşe Gürbüz This is me Sadiye Eren This is me Handan Çetiner This is me
Publication Date	March 1, 2010
Published in Issue	Year 2010 Volume: 41 Issue: 2

Cite

APA	Demirci, O., Bozoklu, Ö., Demirci, E., Tuğrul, S., et al. (2010). Histolojik koioamnionitin erken doğum üzerindeki etkisi. Zeynep Kamil Tıp Bülteni, 41(2), 59-63. https://doi.org/10.16948/zktb.54444
AMA	Demirci O, Bozoklu Ö, Demirci E, Tuğrul S, Gürbüz A, Eren S, Çetiner H. Histolojik koioamnionitin erken doğum üzerindeki etkisi. Zeynep Kamil Tıp Bülteni. March 2010;41(2):59-63. doi:10.16948/zktb.54444
Chicago	Demirci, Oya, Özlem Bozoklu, Elif Demirci, Semih Tuğrul, Ayşe Gürbüz, Sadiye Eren, and Handan Çetiner. “Histolojik Koioamnionitin Erken doğum üzerindeki Etkisi”. Zeynep Kamil Tıp Bülteni 41, no. 2 (March 2010): 59-63. https://doi.org/10.16948/zktb.54444.
EndNote	Demirci O, Bozoklu Ö, Demirci E, Tuğrul S, Gürbüz A, Eren S, Çetiner H (March 1, 2010) Histolojik koioamnionitin erken doğum üzerindeki etkisi. Zeynep Kamil Tıp Bülteni 41 2 59–63.
IEEE	O. Demirci, Ö. Bozoklu, E. Demirci, S. Tuğrul, A. Gürbüz, S. Eren, and H. Çetiner, “Histolojik koioamnionitin erken doğum üzerindeki etkisi”, Zeynep Kamil Tıp Bülteni, vol. 41, no. 2, pp. 59–63, 2010, doi: 10.16948/zktb.54444.
ISNAD	Demirci, Oya et al. “Histolojik Koioamnionitin Erken doğum üzerindeki Etkisi”. Zeynep Kamil Tıp Bülteni 41/2 (March 2010), 59-63. https://doi.org/10.16948/zktb.54444.
JAMA	Demirci O, Bozoklu Ö, Demirci E, Tuğrul S, Gürbüz A, Eren S, Çetiner H. Histolojik koioamnionitin erken doğum üzerindeki etkisi. Zeynep Kamil Tıp Bülteni. 2010;41:59–63.
MLA	Demirci, Oya et al. “Histolojik Koioamnionitin Erken doğum üzerindeki Etkisi”. Zeynep Kamil Tıp Bülteni, vol. 41, no. 2, 2010, pp. 59-63, doi:10.16948/zktb.54444.
Vancouver	Demirci O, Bozoklu Ö, Demirci E, Tuğrul S, Gürbüz A, Eren S, Çetiner H. Histolojik koioamnionitin erken doğum üzerindeki etkisi. Zeynep Kamil Tıp Bülteni. 2010;41(2):59-63.

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