Immunohistochemical evaluation of C-KIT expression in uterine carcinosarcomas

Year 2015, Volume: 46 Issue: 4, 93 - 97, 02.01.2016

Ecmel Işık Kaygusuz

https://doi.org/10.16948/zktb.00912

Abstract

Objective: Carcinosarcoma is a very aggressive neoplasm. The use of tyrosine kinase inhibitors has resulted in successful treatment of KIT-positive neoplasms. Consequently, c-kit expression may have significant clinical implications for this tumor. The purpose of the present study was to assess c-kit expression in the carcinomatous and sarcomatous component of carcinosarcoma and to identify if KIT represents a therapeutic target for treatment of this neoplasm.

Material and Method: Immunohistochemical staining for c-kit was performed on paraffin-embedded tissue blocks of 20 uterine specimens with carcinosarcoma.

Results: In the stromal component of carcinosarcoma, no immunohistochemically c-kit stained cells were observed and in the epithelial component, c-kit staining was present in 9 cases.

Conclusion: The results seem to suggest that c-kit probably plays no major role in the carcinogenesis of the majority of these tumors. Further studies of c-kit expression in larger series of carcinosarcomas must be studied in order to clarify the controversial issues.

Keywords

uterus, c-kit, carcinosarcoma, immuno- histochemistry

Uterin karsinosarkomlarda immunohistokimyasal olarak C-KIT ekspresyonunun değerlendirilmesi

Abstract

Amaç: Karsinosarkom oldukça agresif bir neoplazmdır. KIT-pozitif neoplazmlarda tirozin kinaz inhibitörleri tedavide başarılı sonuçlar vermektedir. Bu nedenle, bu tümörlerde c-kit ekspresyonu klinik açıdan önemli olabilir. Bu çalışmanın amacı, karsinosarkomun karsinomatöz ve sarkomatöz komponenetlerinde c-kit ekspresyonunu incelemek ve bu neoplazmlarda KIT’in terapötik bir hedef olarak kullanılabilirliğini saptamaktır.

Gereç ve Yöntem: Karsinosarkom tanısı almış 20 uterusa ait parafine gömülü bloklara immunohistokimyasal olarak c-kit boyaması uygulandı.

Bulgular: Karsinosarkomların stromal komponentlerinde immunohistakimyasal olarak c-kit boyanan hücre saptanmadı, ve epitelyal komponenette ise 9 olguda c-kit boyaması mevcuttu.

Sonuç: Sonuçlar c-kit’in bu tümörlerin karsinogenezinde muhtemelen major bir rol oynamadığını destekler görünmektedir. Tartışmalı konuları açıklığa kavuşturmak için geniş serilerle yapılacak c-kit ekspresyonunu belirleyecek yeni çalışmalar gerekmektedir.

Keywords

uterus, karsinosarkom, c-kit, immünohistokimya

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