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SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ

Year 2017, Volume: 48 Issue: 4, 157 - 161, 13.12.2017
https://doi.org/10.16948/zktipb.257642

Abstract

Amaç:
Günümüzde görülme sıklığı rölatif olarak artmış olan plasental yapışma
anomalileri (PYA) tiplerine göre ciddi komplikasyonlara yol açmakta, doğum
öncesi invazyon varlığının belirlenmesi ve tipinin açıklanması doğumu
gerçekleştirecek hekim açısından büyük önem taşımaktadır. Bu prospektif,
kesitsel ve tanımlayıcı çalışmanın amacı, en az bir kez sezaryen (C/S) olmuş ve
tekrar C/S planlanan hastalarda preoperatif gri skala ve doppler USG ile PYA açısından
değerlendirip histopatolojik tanı ile karşılaştırmaktır.

Metod:
Bu amaçla Ocak 2013-Temmuz 2013 tarihleri arasında, Yıldırım Beyazıt
Üniversitesi Tıp Fakültesi Ankara Atatürk Eğitim Araştırma Hastanesi Kadın
Hastalıkları ve Doğum bölümüne başvuran, daha öncesinde en az bir kez C/S olan
ve bu gebeliğinde de C/S planlanan toplam 104 olgu çalışma kapsamına alınmıştır.
Bu gebelere preoperatif PYA’nın belirlenmesi amacıyla gri skala ve doppler USG
yapılıp, intraoperatif plasental yatak biyopsisi alınarak histopatolojik
inceleme ile karşılaştırılmıştır. 

Sonuç:
C/S
endikasyonlarının %74’ü bir kez C/S, %25,5’i iki kez C/S ve %1’i ikiden fazla
C/S’dir. Hastaların hiçbirinde intraoperatif PYA şüphesi, postoperatif
komplikasyon ve patoloji sonucunda da PYA rastlanmamıştır. %77,9 hastada doppler
USG normal çıkmıştır. %20,2’sinde yalnızca subplasental alanda vaskülarite
artışı, %1,0’inde subplasental alanda vaskülarite artışı ve laküner akım
varlığı, %1,0’inde yalnızca laküner akım varlığı görülmüştür. Gri skala USG’de
%90,4 hastada herhangi bir bulguya rastlanmamıştır. %2,0’sinde plasental lakün
ve retroplasental berrak alan obliterasyonu, %7,6’sında plasental alandaki en
ince miyometriyal kalınlığın <1 mm olduğu görülmüştür.







           Tartışma:
Bizim çalışmamızda PYA görülmemesinin nedeni yapılan cerrahi tekniğe, bireysel
yara iyileşmesi gibi faktörlere bağlanabilir. Anormal plasentasyona neden olan mekanizmalar
hâlâ net değildir. 

References

  • 1. Haris RD, Cho C, Wells WA. Sonography of the plasenta with empasis on patological correlation. Semin Ultrasound CT MR 1996;17: 66-89.
  • 2. Doumouchtsis SK, Arulkumaran S. The morbidly adherent placenta: an overview of management options. Acta Obstet Gynecol Scand 2010;89: 1126-1133.
  • 3. Brosens JJ, Pijnenborg R, Brosens IA. The myometrial junctional zone spiral arteries in normal and abnormal pregnancies. Am J Obstet Gynecol 2002;187: 1416–1423.
  • 4. Lam G, Kuller J, McMahon M. Use of magnetic resonance imaging and ultrasound in the antenatal diagnosis of placenta accreta. J Soc Gynecol Investing 2002;9: 37-40.
  • 5. JM Palacios-Jaraquemada. Diagnosis and management of placenta accreta. Best Practice & Research Clinical Obstetrics and Gynaecology 2008;22: 1133–1148.
  • 6. E. Jauniaux, D. Jurkovic. Placenta accreta: Pathogenesis of a 20th century iatrogenic uterine disease. Placenta 2012; 33(4): 244-251.
  • 7. Gielchinsky Y, Rojansky N, Fasouliotis SJ, Ezra Y. Placenta acreta-summary of 10 years: a survey of 310 cases. Plasenta 2002; 23 (2-3): 210-4.
  • 8. Bauer ST, Bonanno C. Abnormal placentation. Semin Perinatol 2009;33(2): 88-96.
  • 9. Wu S, Kocherginsky M, Hibbard JU. Abnormal placentation: twenty-year analysis. Am J Obstet Gynecol 2005; 192(5): 1458-61.
  • 10. Hull AD, Moore TR. Multiple repeat cesareans and the threat of placenta accreta: incidence, diagnosis, management. Clin Perinatol 2011; 38(2): 285-96.
  • 11. Wong HS, Cheung YK, Zuccollo J, Tait J, Pringle KC. Evaluation of sonographic diagnostic criteria for placenta accreta. J Clin Ultrasound 2008; 36 (9): 551-9.
  • 12. Eller AG, Bennett MA, Sharshiner M, Masheter C, Soisson AP, Dodson M, et al. Maternal morbidity in cases of placenta accreta managed by a multidisci-plinary care team compared with standard obstetric care. Obstet Gynecol 2011; 117 (2 Pt 1): 33-7.
  • 13. Esh-Broder E, Ariel I, Abas-Bashir N, Bdolah Y, Celnikier DH. Placenta accreta is associated with IVF pregnancies: a retrospective chart review. BJOG 2011; 118(19): 1084-9.
  • 14. Beuker JM, Erwich JJ, Khong TY. Is endomyometrial injury during termination of pregnancy or curettage following miscarriage the precursor to placenta accreta? J Clin Pathol 2005; 58(3): 273-5.
  • 15. Usta IM, Hobeika EM, Musa AA, Gabriel GE, Nassar AH. Placenta previa-accreta: risk factors and complications. Am J Obstet Gynecol 2005; 193 (3 Pt 2): 1045 9.
  • 16. M Kamara, JJ Henderson, DA Doherty, JE Dickinson, CE Pennell. The risk of placenta accreta following primary elective caesarean delivery: a case – control study. BJOG. 2013; 120(7): 879-886.
  • 17. Challis JRG. Mechanism of parturit ion and preterm labor. Obstet Gynecol Surv 2000; 55(10): 650-60.
  • 18. Osman I, Young A, Ledingham MA, Thomson AJ, Jordan F, Greer IA, et al. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod 2003; 9(1): 41-5.
  • 19. Khong TY, Robertson WB. Placenta creta and placenta praevia creta. Placenta 1987; 8(4): 399-409.
  • 20. Tantbirojn P, Crum CD, Parast MM. Pathophysiology of placenta creta: the role of deciduas and extravillous cytotrophoblast. Placenta 2008; 29(7): 639–45.
  • 21. Wehrum MJ, Buhimschi IA, Salafia C, Thung S, Bahtiyar MO, Werner EF, et al. Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast. Am J Obstet Gynecol 2011; 204: 411.

Determination of Placenta- Myometrium Relationship in Caesarian Sections

Year 2017, Volume: 48 Issue: 4, 157 - 161, 13.12.2017
https://doi.org/10.16948/zktipb.257642

Abstract

Objective: The relative prevalence of placental
attachment abnormalities (PAA) has been increased lately. They may cause severe
complications in respect to their types, and determining presence and the type
of the invasion before delivery is important for the obstetrician. The
objective of this prospective, cross

sectional and descriptive study was to investigate PAA preoperatively
using gray scale and Doppler ultrasonography (USG) in patients who had a
Caesarian section (C/S) at least once before and scheduled for C/S again,  and to compare the results with
histopathological diagnosis.

Material and Methods: A total of 104
pregnant women who admitted to
Yıldırım Beyazıt University Medical
Faculty,
Atatürk Education and
Research Hospital Obstetrics and Gynecology Department between January and July
2013, and scheduled for C/S were included in the study. All of the included
patients had had C/S before, at least once. Gray scale and Doppler USG was
performed in all patients to determine PAA, and the findings were compared with
the histopathologic results of placental bed biopsy obtained during C/S.

Results: The indications for C/S were previous
C/S once in 74%, previous C/S twice in 25.5%, and previous C/S more than twice
in 1% of the patients. None of the patients had any suspicion for PAA
intraoperatively, postoperative complications, or PAA in the histopathological
diagnosis. There were no findings on Doppler USG in  77.9% of the patients, 20.2% of them had
increased vascularity alone, 1.0% had increased vascularity and lacunar
flow,  and 1.0% had lacunar flow alone in
the subplasental region. There were no findings on gray scale USG in 90.4% of
the patients. There were placental lacunae and obliteration of the
retroplacental clear zone in 2.0% of the patients, and the thinnest myometrial
wall was < 1 mm
in the placental region in 7.6% of them.







Conclusion: Absence of PAA in
our series may be due to factors such as our surgical technique, and individual
wound healing processes. The mechanisms causing abnormal placentation are not
still clear 

References

  • 1. Haris RD, Cho C, Wells WA. Sonography of the plasenta with empasis on patological correlation. Semin Ultrasound CT MR 1996;17: 66-89.
  • 2. Doumouchtsis SK, Arulkumaran S. The morbidly adherent placenta: an overview of management options. Acta Obstet Gynecol Scand 2010;89: 1126-1133.
  • 3. Brosens JJ, Pijnenborg R, Brosens IA. The myometrial junctional zone spiral arteries in normal and abnormal pregnancies. Am J Obstet Gynecol 2002;187: 1416–1423.
  • 4. Lam G, Kuller J, McMahon M. Use of magnetic resonance imaging and ultrasound in the antenatal diagnosis of placenta accreta. J Soc Gynecol Investing 2002;9: 37-40.
  • 5. JM Palacios-Jaraquemada. Diagnosis and management of placenta accreta. Best Practice & Research Clinical Obstetrics and Gynaecology 2008;22: 1133–1148.
  • 6. E. Jauniaux, D. Jurkovic. Placenta accreta: Pathogenesis of a 20th century iatrogenic uterine disease. Placenta 2012; 33(4): 244-251.
  • 7. Gielchinsky Y, Rojansky N, Fasouliotis SJ, Ezra Y. Placenta acreta-summary of 10 years: a survey of 310 cases. Plasenta 2002; 23 (2-3): 210-4.
  • 8. Bauer ST, Bonanno C. Abnormal placentation. Semin Perinatol 2009;33(2): 88-96.
  • 9. Wu S, Kocherginsky M, Hibbard JU. Abnormal placentation: twenty-year analysis. Am J Obstet Gynecol 2005; 192(5): 1458-61.
  • 10. Hull AD, Moore TR. Multiple repeat cesareans and the threat of placenta accreta: incidence, diagnosis, management. Clin Perinatol 2011; 38(2): 285-96.
  • 11. Wong HS, Cheung YK, Zuccollo J, Tait J, Pringle KC. Evaluation of sonographic diagnostic criteria for placenta accreta. J Clin Ultrasound 2008; 36 (9): 551-9.
  • 12. Eller AG, Bennett MA, Sharshiner M, Masheter C, Soisson AP, Dodson M, et al. Maternal morbidity in cases of placenta accreta managed by a multidisci-plinary care team compared with standard obstetric care. Obstet Gynecol 2011; 117 (2 Pt 1): 33-7.
  • 13. Esh-Broder E, Ariel I, Abas-Bashir N, Bdolah Y, Celnikier DH. Placenta accreta is associated with IVF pregnancies: a retrospective chart review. BJOG 2011; 118(19): 1084-9.
  • 14. Beuker JM, Erwich JJ, Khong TY. Is endomyometrial injury during termination of pregnancy or curettage following miscarriage the precursor to placenta accreta? J Clin Pathol 2005; 58(3): 273-5.
  • 15. Usta IM, Hobeika EM, Musa AA, Gabriel GE, Nassar AH. Placenta previa-accreta: risk factors and complications. Am J Obstet Gynecol 2005; 193 (3 Pt 2): 1045 9.
  • 16. M Kamara, JJ Henderson, DA Doherty, JE Dickinson, CE Pennell. The risk of placenta accreta following primary elective caesarean delivery: a case – control study. BJOG. 2013; 120(7): 879-886.
  • 17. Challis JRG. Mechanism of parturit ion and preterm labor. Obstet Gynecol Surv 2000; 55(10): 650-60.
  • 18. Osman I, Young A, Ledingham MA, Thomson AJ, Jordan F, Greer IA, et al. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod 2003; 9(1): 41-5.
  • 19. Khong TY, Robertson WB. Placenta creta and placenta praevia creta. Placenta 1987; 8(4): 399-409.
  • 20. Tantbirojn P, Crum CD, Parast MM. Pathophysiology of placenta creta: the role of deciduas and extravillous cytotrophoblast. Placenta 2008; 29(7): 639–45.
  • 21. Wehrum MJ, Buhimschi IA, Salafia C, Thung S, Bahtiyar MO, Werner EF, et al. Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast. Am J Obstet Gynecol 2011; 204: 411.
There are 21 citations in total.

Details

Subjects Health Care Administration
Journal Section Original Research
Authors

Busra Demir Cendek This is me

Filiz Ayse Avsar

Ozlem Sarici This is me

H. Levent Keskin

Aylin Kılıç Yazgan This is me

Ali İpek This is me

Evrim Bostancı

Publication Date December 13, 2017
Published in Issue Year 2017 Volume: 48 Issue: 4

Cite

APA Cendek, B. D., Avsar, F. A., Sarici, O., Keskin, H. L., et al. (2017). SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ. Zeynep Kamil Tıp Bülteni, 48(4), 157-161. https://doi.org/10.16948/zktipb.257642
AMA Cendek BD, Avsar FA, Sarici O, Keskin HL, Kılıç Yazgan A, İpek A, Bostancı E. SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ. Zeynep Kamil Tıp Bülteni. December 2017;48(4):157-161. doi:10.16948/zktipb.257642
Chicago Cendek, Busra Demir, Filiz Ayse Avsar, Ozlem Sarici, H. Levent Keskin, Aylin Kılıç Yazgan, Ali İpek, and Evrim Bostancı. “SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ”. Zeynep Kamil Tıp Bülteni 48, no. 4 (December 2017): 157-61. https://doi.org/10.16948/zktipb.257642.
EndNote Cendek BD, Avsar FA, Sarici O, Keskin HL, Kılıç Yazgan A, İpek A, Bostancı E (December 1, 2017) SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ. Zeynep Kamil Tıp Bülteni 48 4 157–161.
IEEE B. D. Cendek, F. A. Avsar, O. Sarici, H. L. Keskin, A. Kılıç Yazgan, A. İpek, and E. Bostancı, “SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ”, Zeynep Kamil Tıp Bülteni, vol. 48, no. 4, pp. 157–161, 2017, doi: 10.16948/zktipb.257642.
ISNAD Cendek, Busra Demir et al. “SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ”. Zeynep Kamil Tıp Bülteni 48/4 (December 2017), 157-161. https://doi.org/10.16948/zktipb.257642.
JAMA Cendek BD, Avsar FA, Sarici O, Keskin HL, Kılıç Yazgan A, İpek A, Bostancı E. SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ. Zeynep Kamil Tıp Bülteni. 2017;48:157–161.
MLA Cendek, Busra Demir et al. “SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ”. Zeynep Kamil Tıp Bülteni, vol. 48, no. 4, 2017, pp. 157-61, doi:10.16948/zktipb.257642.
Vancouver Cendek BD, Avsar FA, Sarici O, Keskin HL, Kılıç Yazgan A, İpek A, Bostancı E. SEZARYENLERDE PLASENTANIN MYOMETRİUM İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ. Zeynep Kamil Tıp Bülteni. 2017;48(4):157-61.