Endometriyal Hiperplazi ve Endometrioid Endometrium Karsinomunun Tanısında PTEN, MLH1, ARID1A ve Β-Katenin, Biyolojik Belirteçlerin Yararları
Abstract
Amaç: Endometriyal karsinomlar kabaca iki gruba ayrılır:
Endometrioid (Tip I) ve Endometrioid olmayan (Tip II). Endometriyum
karsinomlarının büyük çoğunluğu endometrioid tiptedir ve bu tip karsinoma,
hiperplazi ile ilişkili olup, bu hiperplazi, karşılanmamış östrojen nedeniyle
oluşur. Bu çalışmada amacımız, PTEN, MLH1, ARID1A ve β- kateninin; endometrial
hiperplazi (EH) ve endometrioid endometrium karsinom (EC) tanısındaki yararını
saptamaya amaçladık.
Gereç ve Yöntem: İstanbul Medeniyet Üniversitesi Göztepe Eğitim ve
Araştırma Hastanesi’ n de tespit edilen 82 EC olgu, atipik olmayan 71 basit EH
olgusu, atipik olmayan 16 kompleks EH olgusu, 9 basit atipik EH olgusu, 24
kompleks atipik EH olgusu içeren 202 olgu ile retrospektif bir çalışma yaptık.
Kontrol amacıyla 10 normal endometriyal doku kullandık.
Sonuç: Çalışmamızda, EC'li hastalarda PTEN oranı kaybı% 61,
ARID1A kaybı% 52,4, MLH1 kaybı% 40,2 idi. Atipik kompleks EH'li hastalarda bu
oranlar sırasıyla% 87,5,% 41,7 ve% 20,8; Atipik olmayan basit EH'li hastalarda bu
oran sırasıyla % 12,7; % 4,2; % 1,4 olarak saptandı.
Sonuç: Bu bulgular ışığında PTEN, ARID1A ve MLH1'in basit
EH'den atipik kompleks EH'ye geçişte rolü olduğu ve MLH1'in atipik kompleks
EH'den EC'ye geçişte rolü olduğu gösterilmiştir.
References
- Sherman ME et al. Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. ModPathol (1997) 10:963-968.
Utility of PTEN, MLH1, ARID1A and β-catenin, biomarkers in endometrial hyperplasia and endometrioid endometrial carcinoma
Abstract
Objective: Endometrial carcinomas are divided
into two groups roughly:Endometrioid (Type I) and Non-endometrioid (Type II). The majority of the endometrial carcinomas are of endometrioid type and,
this type of carcinoma is associated with hyperplasia which is formed due to
unopposed estrogen.In
this study, our purpose is to reveal the expression status of the PTEN, MLH1, ARID1A
and β-catenin, biomarkers in all types of endometrial hyperplasia (EH) and endometrioid
endometrial carcinoma (EC).
Materials and metods: We conducted a retrospective study
with 202 cases including 82 EC cases, 71 simple EH cases without atypia, 16
complex EH cases without atypia, 9 simple atypical EH cases, 24 complex
atypical EH cases which were diagnosed at Istanbul Civilization University
Göztepe Training and Research Hospital. 10 normal endometrial tissues were used
for the purpose of control.
Resuls: In our study, loss of PTEN ratio was 61%, loss
of ARID1A ratio was 52,4%, loss of MLH1 ratio was 40,2% in patients with EC.
These ratios were 87,5%, 41,7%, 20,8%, respectively in patients with atypical
complex EH and 12,7%; 4,2%; 1,4% in patients with simple EH without atypia.
Conclusions: In the light of these findings it
has been demonstrated that PTEN, ARID1A and MLH1 have a role in the transition
from simple EH to atypical complex EH, and also MLH1 has a role in the transition
from aytpical complex EH to EC.
References
- Sherman ME et al. Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. ModPathol (1997) 10:963-968.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research |
| Authors | |
| Publication Date | March 5, 2018 |
| Published in Issue | Year 2018 Volume: 49 Issue: 1 |
