FLUVASTATİNİN TAVŞAN KAROTİD ARTERİ YAKA MODELİNDE İNTİMAL KALINLAŞMA ÜZERİNE ETKİLERİ

Year 2018, Volume: 49 Issue: 1, 144 - 147, 04.04.2018

Mehmet Zuhuri Arun , Gülnur Sevin Şule Ayla , Gülperi Öktem , Günay Yetik Anacak Levent Üstünes

https://doi.org/10.16948/zktipb.397803

Abstract

Amaç: Statinlerin
LDL-kolesterol düşürücü etkilerinden bağımsız endotel fonksiyonu gibi aterosklerozun
pek çok bileşeni üzerinde de etkileri mevcuttur. Bu etkileri pleiotropik
etkileri olarak da bilinmektedir. Bu çalışmada fluvastatinin normokolesterolemik
tavşanlarda intimal kalınlaşma üzerine etkisinin araştırılması planlanmıştır.

Gereç ve Yöntem: Çalışmada Yeni Zelanda tavşanlarına 3 hafta boyunca
fluvastatin (8 mg/kg/gün oral) ve plasebo tedavi uygulandı. Tedavinin sekizinci
gününde okluzif olmayan silikon bir yaka sol karotid arterinin çevresine
yerleştirilerek on dört gün daha tedaviye devam edildi. Deney sonunda sağ ve
sol karotid arterler çıkarıldı. Çıkarılan karotid arterlerden alınan kesitlerde
morfometrik ölçümler gerçekleştirildi. İntima, medya, lümen ve eksternal
elastik lamina alanları ölçülerek indeks, rezidüel lümen oranı değerleri
hesaplandı.

Bulgular: Yaka intimal
alan ve indeks değerinde belirgin bir artışa ve RLO değerinde azalmaya neden
olurken fluvastatin yakanın neden olduğu intimal kalınlaşmayı inhibe etti.

Sonuç: Bulgularımız
fluvastatinin kolesterol düşürücü etkisinden bağımsız aterosklerozun erken
döneminde de yararlı etkileri olabileceğini göstermektedir.

Keywords

fluvastatin, statin, intimal kalınlaşma, yaka modeli, karotid arteri

Effects of fluvastatin on intimal thickening in rabbit carotid artery collar model

Abstract

Objective: Statins may
exert effects that are independent of LDL-cholesterol lowering on many
components of atherosclerosis including endothelial function, called
pleiotropic effects. In this study we aimed to investigate effects of
fluvastatin on intimal thickening in normocholesterolemic rabbits.

Materials &Method: New Zeeland
rabbits were treated with fluvastatin (8 mg/kg/day, p.o.) and placebo for 3
weeks. On the 8th day, a non-occlusive silicon collar was positioned around the
left carotid artery for 14 days and then both carotid arteries were isolated.
Intimal, medial, lumen and external elastic lamina cross sectional areas were
measured by computer based morphometric analysis and index (intima/media),
residual luminal ratio (RLR) values were calculated.

Results: Collar
caused significant increase in intimal area, index values and decrease in RLR
values. Fluvastatin treatment significantly inhibit collar-induced intimal
thickening.

Conclusion: These
findings indicate that fluvastatin may have beneficial effects on the early
stages of normocholesterolemic atherosclerosis.

Keywords

fluvastatin, statins, intimal thickening, collar, carotid artery

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