Açıklanamayan infertilide endometriyal kalınlık ve canlı doğum

Year 2019, Volume: 50 Issue: 3, 142 - 145, 15.09.2019

Ali Ovayolu , İsmet Gün , Dilek Benk Şilfeler , Tayfun Kutlu

https://doi.org/10.16948/zktipb.550114

Cited By: 1

Abstract

Amaç: Açıklanmayan infertilide
human
koryonik gonadotropin (hCG) günü ölçülen endometriyal kalınlık ile canlı doğum oranları
arasında ilişki olup, olmadığını araştırmaktır.

Gereç
ve Yöntemler: Bu araştırma 2005-2013 yılları arasında Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve
Araştırma hastanesinde tüp bebek tedavisi uygulanmış hastalarda yapılan
retrospektif bir çalışmadır. Çalışmaya 23-39 yaş aralığında, vücut kitle
indeksi 30 kg/m² altında olan ve embriyoda herhangi bir işlemin
yapılmadığı ve taze embriyo transferi yapılmış kadınlar dahil edildi. Hastalar
canlı doğum yapıp (grup 1), yapmamalarına (grup 2) göre 2 gruba ayrıldı. hCG
günü 2-boyutlu ultrason ile midsagittal planda ölçülen endometriyal doku
kalınlığı, siklus tedavi karakterleri ve hastaya ait demografik karakterler gruplar
arasında karşılaştırıldı. Ayrıca hCG günü ölçülen endometriyal doku kalınlığına
göre; 7 mm ve altı, 8 mm, 9 mm, 10 mm, 11 mm, 12 mm, 13 mm ve 14 mm ve üstü
olan subgruplar oluşturuldu. Bu subgruplar arasında canlı doğum yüzdeleri
açısından karşılaştırmalar yapıldı. İstatistiksel karşılaştırmada devamlı
veriler için student t-testi ve kategorik değerler için ki-kare testi
kullanıldı.

Bulgular: Çalışmaya
359 hasta dahil edildi, 104 hasta grup 1 ve 255 hasta grup 2. Gruplar arasında hCG
günü ölçülen estradiol seviyeleri (pg/ml) dışında fark yoktu (2517.2±1106.0 ve
2210.8±991.7, sırasıyla; p=0.011). Her bir endometriyal doku kalınlığından
oluşturulan subgruplar arasında en yüksek canlı doğum oranı 13 mm de %36.8 iken,
en düşük canlı doğum oranı 12 mm de %23.9 idi. Fakat subgruplar arasında canlı
doğum oranları açısından istatistiksel olarak bir fark bulunamadı.

Sonuç:  Açıklanamayan infertilitede canlı
doğum oranları hCG günü ölçülen endometriyal doku kalınlığından bağımsızdır. 

Keywords

açıklanamayan infertilite; tüp bebek; endometriyal kalınlık; canlı doğum oranı

Live Birth and Endometrial Thickness in Unexplained Infertility

Abstract

Objective: We aimed to demonstrate any possible relationship
between endometrial thickness on the day of hCG trigger and live birth rates
(LBRs) among women with unexplained infertility who underwent IVF/ICSI-ET cycles.

Materials and Methods: We
retrospectively collected data from Zeynep Kamil Women's and Children's Disease
Training and Research Hospital, IVF Center archive. Cases between
2005 and 2013 were collected. Women aged between 23-39 years with a
BMI <30 kg/m² with fresh embryo transfers were included. Patients
were divided into two groups based on their livebirth status (live birth: group
1, no live birth: group 2). Demographic characteristics, treatment regimens,
and endometrial thickness on the day of hCG trigger were compared between the two
groups. In addition, patients were divided into subgroups according to the
endometrial thickness on the day of hCG trigger (≤7 mm, 8 mm, 9 mm, 10 mm, 11 mm,
12 mm, 13 mm, and ≥14 mm, respectively). LBRs were compared between these
subgroups.

Results:  Three hundred fifty-nine cycles (group 1: n=104, group 2: n=255) were included for
statistical analysis. Other than estradiol level (pg/mL) on the day of hCG
trigger (2517.2±1106.0,
2210.8±991.7, respectively; p=0.011), there were no statistically significant differences between the two
groups. Among the subgroups based on endometrial thickness, the highest LBR was
detected in the 13 mm subgroup (36.8%) and lowest LBR was detected in 12 mm
subgroup (23.9%). However, LBRs were not statistically significant between the
subgroups.

Conclusion: LBRs
do not seem to be affected by endometrial thickness on the day of hCG trigger
among couples with unexplained infertility. 

Keywords

unexplained infertility; in-vitro fertilization; endometrial thickness; live birth pregnancy rate

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