Year 2018, Volume 8, Issue 4, Pages 295 - 298 2018-12-31

Primer Biliyer Kolanjit ve Otoimmün Karaciğer Hastalıklarında Çölyak Hastalığı Prevalansı
Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis

Genco Gencdal [1] , Cenk Emre Meral [2] , Elif Azarsız [3] , Güzide Aksu [4] , Fulya Günşar [5] , Ulus Salih Akarca [6]

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Giriş: Çölyak hastalığı (ÇH),  glutene maruz kalındığında oluşan bir ince  bağırsak hastalığıdır. ÇH,  dermatitis herpetiformis, otoimmün tiroid hastalığı, tip 1 diabetes mellitus ve otoimmün karaciğer hastalıkları ile sıklıkla birliktelik  gösterir. Otoimmün hepatit (OİH) ve primer biliyer kolanjit (PBK) en sık görülen otoimmün karaciğer hastalıklarıdır. Bu çalışmada, hastanemizde PBK, OİH ve  PBK + OİH overlap tanılı  hastalarda  ÇH sıklığını araştırdık.

Metod: PBK, OİH ve  OİH + PBK overlap tanılı  hastalar çalışmaya dahil edilmiştir.ÇH tanısı spesifik serum antikorları ve spesifik duodenal biyopsi  bulguları ile konulmuştur.

Sonuçlar: PBK  (n = 47; F:% 95.7; yaş: 53 ± 10 yıl), OİH (n = 23; F:% 100; yaş: 48 ± 12 yıl) ve  OİH + PBK overlap (n = 29, F:% 96.6, yaş: 51 ± 10.9 yıl) tanılı  toplam  99 hasta çalışmaya dahil edilmiştir. PBC grubundaki üç (% 6.4),OİH grubunda 2 (% 8.7), PBK+OİH  overlap grubunda 1(% 3) hastaya serolojik ve histolojik bulgulara dayanarak ÇH tanısı  konuluştur.

Tartışma: Tek başına anti-gliadin antikoru (AGA) pozitifliği veya tek başına anti-endomisyum antikoru (EMA) pozitifliği ÇH  tanısı için yeterli değildir. Daha  kesin tanı  için,  ÇH  taramasında  her  2  testin  birlikte  kullanılmasını ve ÇH spesifik  antikorların  pozitif  tespit  edildiği olgularda, tanının duodenum  biyopsiyle  desteklenmesini öneriyoruz.  

Background: Coeliac disease (CD) is a small bowel disease, which occurs upon exposure to dietary gluten. CD is often associated with dermatitis herpetiformis, autoimmune thyroid disease, type 1 diabetes mellitus and autoimmune liver diseases. Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are the most common autoimmune liver diseases. In this study, we investigated the prevalence of CD in patients with PBC, AIH and overlapping PBC + AIH  in our Hospital.

Methods: Ninety-nine patients with PBC, AIH and overlapping AIH + PBC were included in this study. Specific serum antibodies and specific duodenal biopsy results are  used  for  diagnosis  of  CD.

Results: Ninety-nine patients with PBC (n = 47; F: 95.7%; age: 53 ± 10 years), AIH (n = 23; F: 100%; age: 48 ± 12 years) and overlapping AIH + PBC (n = 29;F : 96.6%; age: 51 ± 10.9 years) were included in this study.Three patients (6.4%) in the PBC group, one patient (3%) in the PBC + AIH group and two patients (8.7%) in the AIH group were serologically and histologically diagnosed with CD.

Conclusion: Anti-gliadine antibody (AGA) positivity or anti-endomysium antibody (EMA) positivity alone was not sufficient for CD diagnosis. We suggest using both tests for CD screening to achieve more accurate results. In cases of positive CD-specific antibody results, we advise confirming the diagnosis by histopathological examination of duodenal biopsies.

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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Research
Authors

Orcid: 0000-0002-5856-5384
Author: Genco Gencdal (Primary Author)
Institution: İSTANBUL YENİ YÜZYIL ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0003-4091-626X
Author: Cenk Emre Meral
Institution: EGE TIP PR.
Country: Turkey


Orcid: 0000-0002-2887-7029
Author: Elif Azarsız
Institution: EGE TIP PR.
Country: Turkey


Orcid: 0000-0003-2714-0903
Author: Güzide Aksu
Institution: EGE TIP PR.
Country: Turkey


Orcid: 0000-0002-6002-4819
Author: Fulya Günşar
Institution: EGE TIP PR.
Country: Turkey


Author: Ulus Salih Akarca

Bibtex @research article { gopctd468748, journal = {Çağdaş Tıp Dergisi}, issn = {}, eissn = {2146-6009}, address = {Selcuk University}, year = {2018}, volume = {8}, pages = {295 - 298}, doi = {10.16899/gopctd.468748}, title = {Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis}, key = {cite}, author = {Gencdal, Genco and Meral, Cenk Emre and Azarsız, Elif and Aksu, Güzide and Günşar, Fulya and Akarca, Ulus Salih} }
APA Gencdal, G , Meral, C , Azarsız, E , Aksu, G , Günşar, F , Akarca, U . (2018). Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis. Çağdaş Tıp Dergisi, 8 (4), 295-298. DOI: 10.16899/gopctd.468748
MLA Gencdal, G , Meral, C , Azarsız, E , Aksu, G , Günşar, F , Akarca, U . "Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis". Çağdaş Tıp Dergisi 8 (2018): 295-298 <http://dergipark.org.tr/gopctd/issue/39480/468748>
Chicago Gencdal, G , Meral, C , Azarsız, E , Aksu, G , Günşar, F , Akarca, U . "Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis". Çağdaş Tıp Dergisi 8 (2018): 295-298
RIS TY - JOUR T1 - Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis AU - Genco Gencdal , Cenk Emre Meral , Elif Azarsız , Güzide Aksu , Fulya Günşar , Ulus Salih Akarca Y1 - 2018 PY - 2018 N1 - doi: 10.16899/gopctd.468748 DO - 10.16899/gopctd.468748 T2 - Çağdaş Tıp Dergisi JF - Journal JO - JOR SP - 295 EP - 298 VL - 8 IS - 4 SN - -2146-6009 M3 - doi: 10.16899/gopctd.468748 UR - https://doi.org/10.16899/gopctd.468748 Y2 - 2018 ER -
EndNote %0 Çağdaş Tıp Dergisi Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis %A Genco Gencdal , Cenk Emre Meral , Elif Azarsız , Güzide Aksu , Fulya Günşar , Ulus Salih Akarca %T Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis %D 2018 %J Çağdaş Tıp Dergisi %P -2146-6009 %V 8 %N 4 %R doi: 10.16899/gopctd.468748 %U 10.16899/gopctd.468748
ISNAD Gencdal, Genco , Meral, Cenk Emre , Azarsız, Elif , Aksu, Güzide , Günşar, Fulya , Akarca, Ulus Salih . "Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis". Çağdaş Tıp Dergisi 8 / 4 (December 2019): 295-298. https://doi.org/10.16899/gopctd.468748