Primer Biliyer Kolanjit ve Otoimmün Karaciğer Hastalıklarında Çölyak Hastalığı Prevalansı

Yıl 2018, Cilt: 8 Sayı: 4, 295 - 298, 31.12.2018

Genco Gencdal , Cenk Emre Meral Elif Azarsız Güzide Aksu , Fulya Günşar , Ulus Salih Akarca

https://doi.org/10.16899/gopctd.468748

Öz

Giriş: Çölyak hastalığı
(ÇH),  glutene maruz kalındığında oluşan
bir ince  bağırsak hastalığıdır. ÇH,  dermatitis herpetiformis, otoimmün tiroid
hastalığı, tip 1 diabetes mellitus ve otoimmün karaciğer hastalıkları ile
sıklıkla birliktelik  gösterir. Otoimmün
hepatit (OİH) ve primer biliyer kolanjit (PBK) en sık görülen otoimmün
karaciğer hastalıklarıdır. Bu çalışmada, hastanemizde PBK, OİH ve  PBK + OİH overlap tanılı  hastalarda  ÇH sıklığını araştırdık.

Metod: PBK, OİH ve  OİH + PBK overlap tanılı  hastalar çalışmaya dahil edilmiştir.ÇH tanısı
spesifik serum antikorları ve spesifik duodenal biyopsi  bulguları ile konulmuştur.

Sonuçlar: PBK  (n = 47; F:% 95.7; yaş: 53 ± 10 yıl), OİH (n =
23; F:% 100; yaş: 48 ± 12 yıl) ve  OİH +
PBK overlap (n = 29, F:% 96.6, yaş: 51 ± 10.9 yıl) tanılı  toplam 
99 hasta çalışmaya dahil edilmiştir. PBC grubundaki üç (% 6.4),OİH
grubunda 2 (% 8.7), PBK+OİH  overlap
grubunda 1(% 3) hastaya serolojik ve histolojik bulgulara dayanarak ÇH
tanısı  konuluştur.

Tartışma: Tek başına
anti-gliadin antikoru (AGA) pozitifliği veya tek başına anti-endomisyum
antikoru (EMA) pozitifliği ÇH  tanısı
için yeterli değildir. Daha  kesin
tanı  için,  ÇH 
taramasında  her  2 
testin  birlikte  kullanılmasını ve ÇH spesifik  antikorların 
pozitif  tespit  edildiği olgularda, tanının duodenum  biyopsiyle 
desteklenmesini öneriyoruz.  

Anahtar Kelimeler

Çölyak hastalığı, primer biliyer kolanjit, otoimmün karaciğer hastalığı

Prevalence of Coeliac Disease in Autoimmune Liver Disease and Primary Biliary Cholangitis

Öz

Background:
Coeliac disease (CD) is a small
bowel disease, which occurs upon exposure to dietary gluten. CD is often
associated with dermatitis herpetiformis, autoimmune thyroid disease, type 1
diabetes mellitus and autoimmune liver diseases. Autoimmune hepatitis (AIH) and
primary biliary cholangitis (PBC) are the most common autoimmune liver
diseases. In this study, we investigated the prevalence of CD in patients with
PBC, AIH and overlapping PBC + AIH  in
our Hospital.

Methods:
Ninety-nine patients with PBC, AIH and overlapping AIH + PBC were included in
this study. Specific serum antibodies and specific duodenal biopsy results
are  used 
for  diagnosis  of  CD.

Results:
Ninety-nine patients with PBC (n =
47; F: 95.7%; age: 53 ± 10 years), AIH (n = 23; F: 100%; age: 48 ± 12
years) and overlapping AIH + PBC (n = 29;F : 96.6%; age: 51 ± 10.9 years) were
included in this study.Three patients (6.4%) in the PBC group, one patient (3%)
in the PBC + AIH group and two patients (8.7%) in the AIH group were
serologically and histologically diagnosed with CD.

Conclusion: Anti-gliadine antibody (AGA) positivity or
anti-endomysium antibody (EMA) positivity alone was not sufficient for CD
diagnosis. We suggest using both tests for CD screening to achieve more
accurate results. In cases of positive CD-specific antibody results, we advise
confirming the diagnosis by histopathological examination of duodenal biopsies.

Anahtar Kelimeler

Coeliac disease, Autoimmune hepatitis, Primary biliary cholangitis

Kaynakça

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