Year 2017, Volume 20, Issue 3, Pages 153 - 157 2017-09-01

Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea

Rongchun Li [1] , Keyan Sun [2] , Yushan Hua [3] , Zhicheng Tan [4] , Quan Shi [5]

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The investigation on thermodynamic properties of drug intermediates plays a crucial role in the design and synthesis of new drugs as well as understanding their biological activities in vivo. In this work, the thermodynamic properties of two drug intermediates of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea were studied by means of low temperature calorimety performed in a Physical Property Measurement System calorimeter. The heat capacities of these two compounds were measured over the temperature region from (1.9 to 300) K, and the corresponding thermodynamic functions were consequently calculated on the basis of the heat capacity curve fitting. Additionally, a group additivity method were employed for estimating the heat capacity values of these two compounds at 298.15 K, which are in good agreement with the values measured in this work.

3-fluoro-5-(3-pyridinyloxy) benzenamine, N-, 3-fluoro-5-(3-pyridinyloxy)phenyl, -N’-3-pyridinyl urea, Low temperature calorimetry, Heat capacity
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Subjects Engineering
Journal Section Regular Original Research Article
Authors

Author: Rongchun Li
Institution: Key Laboratory of Coordination Chemistry and Functional Materials, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, Shandong 253023, China
Country: China


Author: Keyan Sun
Institution: Thermochemistry Laboratory, Liaoning Province Key Laboratory of Thermochemistry for Energy and Materials, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Country: China


Author: Yushan Hua
Institution: Key Laboratory of Coordination Chemistry and Functional Materials, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, Shandong 253023, China
Country: China


Author: Zhicheng Tan
Institution: Thermochemistry Laboratory, Liaoning Province Key Laboratory of Thermochemistry for Energy and Materials, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Country: China


Author: Quan Shi
Institution: Thermochemistry Laboratory, Liaoning Province Key Laboratory of Thermochemistry for Energy and Materials, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Country: China


Dates

Publication Date: September 1, 2017

Bibtex @short communication { ijot292047, journal = {International Journal of Thermodynamics}, issn = {1301-9724}, eissn = {2146-1511}, address = {Uluslararası Uygulamalı Termodinamik Derneği İktisadi İşletmesi}, year = {2017}, volume = {20}, pages = {153 - 157}, doi = {10.5541/eoguijt.292047}, title = {Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea}, key = {cite}, author = {Li, Rongchun and Sun, Keyan and Hua, Yushan and Tan, Zhicheng and Shi, Quan} }
APA Li, R , Sun, K , Hua, Y , Tan, Z , Shi, Q . (2017). Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea. International Journal of Thermodynamics, 20 (3), 153-157. DOI: 10.5541/eoguijt.292047
MLA Li, R , Sun, K , Hua, Y , Tan, Z , Shi, Q . "Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea". International Journal of Thermodynamics 20 (2017): 153-157 <http://dergipark.org.tr/ijot/issue/31047/292047>
Chicago Li, R , Sun, K , Hua, Y , Tan, Z , Shi, Q . "Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea". International Journal of Thermodynamics 20 (2017): 153-157
RIS TY - JOUR T1 - Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea AU - Rongchun Li , Keyan Sun , Yushan Hua , Zhicheng Tan , Quan Shi Y1 - 2017 PY - 2017 N1 - doi: 10.5541/eoguijt.292047 DO - 10.5541/eoguijt.292047 T2 - International Journal of Thermodynamics JF - Journal JO - JOR SP - 153 EP - 157 VL - 20 IS - 3 SN - 1301-9724-2146-1511 M3 - doi: 10.5541/eoguijt.292047 UR - https://doi.org/10.5541/eoguijt.292047 Y2 - 2017 ER -
EndNote %0 International Journal of Thermodynamics Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea %A Rongchun Li , Keyan Sun , Yushan Hua , Zhicheng Tan , Quan Shi %T Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea %D 2017 %J International Journal of Thermodynamics %P 1301-9724-2146-1511 %V 20 %N 3 %R doi: 10.5541/eoguijt.292047 %U 10.5541/eoguijt.292047
ISNAD Li, Rongchun , Sun, Keyan , Hua, Yushan , Tan, Zhicheng , Shi, Quan . "Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea". International Journal of Thermodynamics 20 / 3 (September 2017): 153-157. https://doi.org/10.5541/eoguijt.292047
AMA Li R , Sun K , Hua Y , Tan Z , Shi Q . Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea. International Journal of Thermodynamics. 2017; 20(3): 153-157.
Vancouver Li R , Sun K , Hua Y , Tan Z , Shi Q . Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea. International Journal of Thermodynamics. 2017; 20(3): 157-153.