Investigation of gestational diabetic lipid levels

Yıl 2019, Cilt: 2 Sayı: 3, 84 - 87, 01.07.2019

Faruk Yıldız Aykut Turhan Fatih Sönmez İdris Baydar Şenay Durmaz Ceylan Mehmet Öztürk Aydın Çifci Betül Güzel Ayşe Çarlıoğlu

https://doi.org/10.32322/jhsm.410857

Öz

Aim: Abnormal lipid
profiles have been associated with gestational diabetes mellitus (GDM). We
aimed to investigatethe lipid profile in gestational diabetes.

Methots:  This study was included 127 GDM and 30
healthy pregnant women to control group, similar BMI, gestational week and age
group. Total cholesterol, high density lipoprotein (HDL-C) plasma
concentrations were measured by cholesterol enzymatic tests. Low-density
lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula.

Findings: Triglyceride,
Total Cholesterol and LDL-C levels were found to be increased in pregnancy.
However, it was not statistically significant. GDM compared with the control
group in HDL-C were statistically significantly lower. When logistic regression
was performed, HDL was lower than GDM control, regardless of age, BMD,
gestational week. When Roc analysis was performed, it was seen that HDL <70
mg / dL GDM was predicted with 83% specificity and 64% sensitivity.

Results:
Low HDL-C concentrations were significantly associated
with an increased risk of GDM. Total cholesterol, LDL-C, TG values were not
significantly elevated.

Anahtar Kelimeler

Gestasyonel diyabetes mellitus (gdm), Lipid düzeyleri, Total kolesterol, Hdl-k, Ldl-k, Trigliserit

Gestasyonel diyabette lipid düzeylerinin incelenmesi

Öz

Amaç: Anormal lipid
profilleri gestasyonel diabetes mellitus (GDM) ile ilişkilendirilmiştir. Biz
gestasyonel diyabette lipid profilini incelemeyi amaçladık.

Metod: Çalışmamıza 127 GDM’li
ve kontrol grubu olarak benzer BMİ, gebelik haftası ve yaş grubundan 30
sağlıklı gebe dahil edildi. Kan örnekleri12 saat açlıktan sonra alındı.  Trigliserid,
Total Kolesterol, yüksek yoğunluklu lipoprotein(HDL-K)plazma konsantrasyonları kolesterol
enzimatik testlerle ölçüldü. Düşük yoğunluklu lipoprotein kolesterol(LDL-K)
Friedewald'ın formülü ile hesaplandı.

Bulgular: Trigliserid, Total
Kolesterol ve LDL-K düzeyleri gebelikte artmış olarak bulundu. Ancak
istatistiksel olarak anlamlı değildi. Hdl-k GDM grubunda kontrol ile karşılaştırılınca
istatistiksel olarak anlamlı bir şekilde düşük bulundu. Logistik regresyon
yapıldığında HDL’nin GDM’de kontrole göre düşük olması yaş, BMİ, gebelik
haftasından bağımsız olarak bulundu. Roc analiz yapıldığında HDL < 70
mg/dl  GDM’yi %83 spesifite,  %64 sensivite ile predikte ettiği görüldü.

Sonuç: Düşük HDL-C
konsantrasyonları, GDM riskinde artış ile anlamlı şekilde ilişkiliydi. Total
kolesterol, LDL-C, TG değerlerinde anlamlı yükselmeler görülmedi.

Anahtar Kelimeler

Gestasyonel diyabetes mellitus (gdm), Lipid düzeyleri, Total kolesterol, Hdl-k, Ldl-k, Trigliserit

Kaynakça

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