Year 2018, Volume 3, Issue 2, Pages 106 - 110 2018-12-30

Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

Özlem ÖZMEN [1] , Ezgi OGUS [2]

22 120

Transmissible venereal tumor (TVT) is a sexually transmitted, naturally occurring tumor of the canine family and often occurs in tropical and subtropical countries. The matrix metalloproteinases (MMPs) are endogenous proteases accountable for the degradation of extracellular matrix (ECM) components, such as collagen and other proteins including the basement membrane. MMPs play a vital role in the tumor metastasis and angiogenesis. Both MMP-2 and -7 strongly associated with the invasion and metastasis of different cancer types. This study aims to investigate the MMP-2 and -7 expression in naturally occurring TVT in 20 dogs using immunohistochemical methods. Immunohistochemically, we observed increased MMP-2 and -7 expressions in tumor cells. In addition, a positive correlation was determined between the tumor size and immunoexpressions of the markers indicating that both MMP-2 and -7 participate in the TVT pathogenesis.


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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Orcid: 0000-0002-1835-1082
Author: Özlem ÖZMEN (Primary Author)
Institution: MEHMET AKIF ERSOY UNIVERSITY, FACULTY OF VETERINARY
Country: Turkey


Author: Ezgi OGUS
Institution: MEHMET AKIF ERSOY UNIVERSITY, FACULTY OF VETERINARY
Country: Turkey


Bibtex @research article { maeuvfd481960, journal = {Veterinary Journal of Mehmet Akif Ersoy University}, issn = {2458-9268}, eissn = {2148-6239}, address = {Mehmet Akif Ersoy University}, year = {2018}, volume = {3}, pages = {106 - 110}, doi = {10.24880/maeuvfd.481960}, title = {Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs}, key = {cite}, author = {ÖZMEN, Özlem and OGUS, Ezgi} }
APA ÖZMEN, Ö , OGUS, E . (2018). Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs. Veterinary Journal of Mehmet Akif Ersoy University, 3 (2), 106-110. DOI: 10.24880/maeuvfd.481960
MLA ÖZMEN, Ö , OGUS, E . "Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs". Veterinary Journal of Mehmet Akif Ersoy University 3 (2018): 106-110 <http://dergipark.org.tr/maeuvfd/issue/41984/481960>
Chicago ÖZMEN, Ö , OGUS, E . "Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs". Veterinary Journal of Mehmet Akif Ersoy University 3 (2018): 106-110
RIS TY - JOUR T1 - Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs AU - Özlem ÖZMEN , Ezgi OGUS Y1 - 2018 PY - 2018 N1 - doi: 10.24880/maeuvfd.481960 DO - 10.24880/maeuvfd.481960 T2 - Veterinary Journal of Mehmet Akif Ersoy University JF - Journal JO - JOR SP - 106 EP - 110 VL - 3 IS - 2 SN - 2458-9268-2148-6239 M3 - doi: 10.24880/maeuvfd.481960 UR - https://doi.org/10.24880/maeuvfd.481960 Y2 - 2018 ER -
EndNote %0 Veterinary Journal of Mehmet Akif Ersoy University Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs %A Özlem ÖZMEN , Ezgi OGUS %T Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs %D 2018 %J Veterinary Journal of Mehmet Akif Ersoy University %P 2458-9268-2148-6239 %V 3 %N 2 %R doi: 10.24880/maeuvfd.481960 %U 10.24880/maeuvfd.481960
ISNAD ÖZMEN, Özlem , OGUS, Ezgi . "Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs". Veterinary Journal of Mehmet Akif Ersoy University 3 / 2 (December 2019): 106-110. https://doi.org/10.24880/maeuvfd.481960