Yeni Teşhis Edilen Hipertansiyonlu Çocuklarda ElastPQ Tekniği İle Elde Edilen Böbrek Kortikal Sertliği Anlamlı Olarak Artar

Yıl 2019, Cilt: 17 Sayı: 1, 96 - 109, 01.04.2019

Ayşe Selcan Koç Erman Cilsal

Öz

GİRİŞ: Bu
çalışmada hipertansiyon (HT) olan çocuklarda, elastografi point qantifiation
(ElastPQ) incelemesi ile elde edilen böbrek kortikal sertlik (KS) değişiminin
değerlendirilmesi ve bu hastalardaki KS ile ilişkili parametrelerin tespit
edilmesi amaçlandı.

GEREÇ ve
YÖNTEM: Çalışmaya 7–16 yaş aralığında okul çağında yeni tanı HT
olan 40 çocuk ve 20 sağlıklı kontrol alındı. Rutin anamnez, fizik muayene ve
laboratuvar incelemelerine ek olarak böbrek ultrasonografisi (USG) yapıldı.
ElastPQ incelemesi ile böbrek KS düzeyi ölçüldü.

BULGULAR: HT olan
hastalarda; sistolik kan basıncı (SKB), diyastolik kan basıncı (DKB), nabız
basıncı (PP),  LDL kolesterol ve
trigliserid düzeyleri, böbrek kortikal kalınlık ve KS değerleri sağlıklı
kontrollere göre belirgin olarak yüksekti (p<0,05 her biri için). Böbrek KS
ile tek değişkenli analizde SBP, DBP, PP ve böbrek kortikal kalınlık ile
pozitif ve HDL ile negatif olarak ilişkili olduğu bulundu.  Lineer regresyon analizinde, bu
parametrelerden sadece SKB böbrek KS ile yakın olarak ilişkili olduğu tespit
edildi (p<0,001 vs. β=0,395).

SONUÇ: Yeni tanı
HT olan çocuklarda ElastPQ tekniği ile elde edilen böbrek KS artar.
Çalışmamızın sonucuna göre, HT olan çocuklarda hedef organ hasarının erken
belirlemesinde böbrek KS bir kullanılabileceği kanısına varıldı. Ancak bu bulgu
için ek çalışmaların yapılması gerektiği düşünüldü. 

Anahtar Kelimeler

Hipertansiyon, çocuk, böbrek kortikal sertliği

Renal Cortical Stiffness Obtained by ElastPQ Technique is Significantly Increased in Children with Newly Diagnosed Hypertension

Öz

INTRODUCTION: In this study, it was
aimed to evaluate the change of renal cortical stiffness (CS) obtained by
elastography point quantification (ElastPQ) in children with newly diagnosed
hypertension (HT) and to determine the CS-related parameters in these patients.

MATERIALS and METHODS: 40 children with newly
diagnosed HT and 20 healthy controls were included in the study at the age of
7-16 years. Renal ultrasonography (USG) was performed in addition to routine
history, physical examination, and laboratory examinations. Renal CS was
measured by ElastPQ technique.

RESULTS: In patients with HT;
systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure
(PP), LDL cholesterol and triglyceride levels, renal cortical thickness and
renal CS values ​​were significantly higher than in healthy controls (p
<0.05 for each). In univariate analysis with renal CS, it was found that
SBP, DBP, PP and renal cortical thickness were positively correlated. In
contrast, HDL and renal cortical thickness were negatively correlated. In the
linear regression analysis, it was determined that only SBP values ​​were
closely related to renal CS (p<0.001 vs. β=0.395).

CONCLUSION: In children with
newly diagnosed HT, renal CS obtained by ElastPQ technique increases. According
to the results of our study, it was concluded that renal CS may be used in
early detection of target organ damage in children with HT. However, additional
studies were considered necessary for this finding.

Anahtar Kelimeler

Hypertension, children, renal cortical stiffness

Kaynakça

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