Year 2019, Volume 9, Issue 2, Pages 218 - 229 2019-06-28

Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi
Effects of plant sterols/stanols on atherosclerotic process and cardiovascular diseases

Hande Çekici [1] , Hilal Yıldıran [2]

27 72

Tüm dünyada ve ülkemizde kardiyovasküler hastalıklardan kaynaklanan morbiditenin ve mortalitenin ciddi rakamlara ulaştığı bilinmektedir. Günümüzde, yaşam tarzı ve beslenme alışkanlıkları değişimi ile kardiyovasküler hastalıkların morbiditesi artmıştır. Diyet ile alınan bitkisel steroller/stanoller, bu olumsuz çevresel koşulları çeşitli mekanizmalar aracılığıyla değiştirebilir ve iyileştirebilir. Etki mekanizması ise enterohepatik döngü içindeki kolesterol ve lipid düzenleyici hedeflerin regülasyonudur. Bağırsak lümeninde eksojen (diyet) ve endojen kaynaklı kolesterol ile rekabet etmek, bağırsak kolesterolü emilimini azaltmak ve kolesterol sentezinde görevli genlerin ekspresyonunu değiştirmek gibi önemli etkileri vardır. Hepatik döngü içerisindeki etkinliği ile kardiyovasküler hastalıklar için risk faktörü olan total kolesterol, düşük yoğunluklu lipoprotein kolesterol ve trigliserit serum konsantrasyonlarını önemli ölçüde düşürmektedir. Bunun yanı sıra, aterosklerozun patogenezinde önemli rol oynayan plazma fibrinojen düzeylerini ve trombotik etkiye neden olan trombosit düzeylerini azaltarak aterosklerotik sürece etki etmektedir.

It is known that the morbidity and mortality caused by cardiovascular diseases in our country and have reached serious numbers in the world. Nowadays, the morbidity of cardiovascular diseases has increased with changing lifestyle and dietary habits. Dietary plant sterols/stanols may alter and improve these adverse environmental conditions through various mechanisms. The mechanism of action is the regulation of cholesterol and lipid regulatory targets in enterohepatic cycle. There are important effects in the intestinal lumen such as competing with exogenous (dietary) and endogenous cholesterol, reducing the absorption of intestinal cholesterol and altering the expression of genes involved in cholesterol synthesis. Its effectiveness in the hepatic cycle significantly reduces total cholesterol, low density lipoprotein cholesterol and triglyceride serum concentrations, which are risk factors for cardiovascular diseases. In addition, it affects the atherosclerotic process by decreasing plasma fibrinogen levels and thrombotic effects that play an important role in the pathogenesis of atherosclerosis. 

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Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Orcid: 0000-0001-9377-888X
Author: Hande Çekici (Primary Author)
Institution: RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ, SAĞLIK YÜKSEKOKULU
Country: Turkey


Orcid: 0000-0001-7956-5087
Author: Hilal Yıldıran
Institution: GAZİ ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ
Country: Turkey


Dates

Publication Date: June 28, 2019

Bibtex @review { smj527116, journal = {Sakarya Tıp Dergisi}, issn = {}, eissn = {2146-409X}, address = {Sakarya University}, year = {2019}, volume = {9}, pages = {218 - 229}, doi = {10.31832/smj.527116}, title = {Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi}, key = {cite}, author = {Çekici, Hande and Yıldıran, Hilal} }
APA Çekici, H , Yıldıran, H . (2019). Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi. Sakarya Tıp Dergisi, 9 (2), 218-229. DOI: 10.31832/smj.527116
MLA Çekici, H , Yıldıran, H . "Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi". Sakarya Tıp Dergisi 9 (2019): 218-229 <http://dergipark.org.tr/smj/issue/46423/527116>
Chicago Çekici, H , Yıldıran, H . "Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi". Sakarya Tıp Dergisi 9 (2019): 218-229
RIS TY - JOUR T1 - Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi AU - Hande Çekici , Hilal Yıldıran Y1 - 2019 PY - 2019 N1 - doi: 10.31832/smj.527116 DO - 10.31832/smj.527116 T2 - Sakarya Tıp Dergisi JF - Journal JO - JOR SP - 218 EP - 229 VL - 9 IS - 2 SN - -2146-409X M3 - doi: 10.31832/smj.527116 UR - https://doi.org/10.31832/smj.527116 Y2 - 2019 ER -
EndNote %0 Sakarya Medical Journal Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi %A Hande Çekici , Hilal Yıldıran %T Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi %D 2019 %J Sakarya Tıp Dergisi %P -2146-409X %V 9 %N 2 %R doi: 10.31832/smj.527116 %U 10.31832/smj.527116
ISNAD Çekici, Hande , Yıldıran, Hilal . "Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi". Sakarya Tıp Dergisi 9 / 2 (June 2019): 218-229. https://doi.org/10.31832/smj.527116
AMA Çekici H , Yıldıran H . Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi. Sakarya Tıp Dergisi. 2019; 9(2): 218-229.
Vancouver Çekici H , Yıldıran H . Bitkisel Sterollerin/Stanollerin Aterosklerotik Süreç ve Kardiyovasküler Hastalıklar Üzerine Etkisi. Sakarya Tıp Dergisi. 2019; 9(2): 229-218.