Deneysel kardiyovasküler çalışmalarda insan umblikal ven endotel hücrelerinin önemi

Yıl 2019, Cilt: 10 Sayı: 2, 259 - 261, 12.06.2019

Esin Akbay

https://doi.org/10.18663/tjcl.569286

Öz

Günümüzde
damarlarda daralma veya tıkanma sonucunda ortaya çıkan
kardiyovasküler system bozuklukları, insanların yaşam kalitesini
olumsuz yönde etkileyen ve ölüm ile sonuçlanabilen önemli
hastalıkların başında gelmektedir. Bilinen birçok hastalığa
kardiyovasküler system bozuklukları eşlik etmektedir. Bu
nedenlerle kardiyovasküler patolojide active olan farklı yolakların
varlığı ve bu yolakların incelenmesine yönelik çalışmalar
gündeme gelmiş, in
vitro metodların
geliştirilmesine ihtiyaç duyulmuştur. In
vitro hücre
kültürü modelleri, anjiyogenez sürecini düzenleyen
mekanizmaları anlamamızı sağlamak için tercih edilen önemli
modellerdir. İnsan göbek ven endotel hücreleri (HUVEC),
kardiyovasküler system patolojileri ile ilgili çalışmalarda
kullanılan en yaygın in
vitro hücre
modellerinden biridir. Bu derlemede, farklı terapi yaklaşımlarının
değerlendirilmesi için HUVEC'lerin in
vitro bir
model olarak kullanım alanları üzerinde durulmuştur.

Anahtar Kelimeler

insan umblikal ven endotel hücresi, kardiyovasküler hastalıklar, in vitro, model

Importance of human umbilical vein endothelial cells in experimental cardiovascular studies

Öz

Nowadays,
cardiovascular system disorders caused by narrowing or obstruction of
the vascular system lead to the most important diseases that have a
negative effect on the quality of life and have fatal consequences.
It is known that many diseases are accompanied by cardiovascular
system disorders. For these reasons, studies on the existence of
different pathways activated in cardiovascular pathology and the
investigation of these pathways have come intoquestion, and in
vitro
methods have been needed to be developed. in
vitro
cell culture models are the preferred models to enable understanding
the mechanisms that regulate the process of angiogenesis. Human
umbilical vein endothelial cells (HUVEC) are one of the most common
in
vitrocell
models used in vascular studies within the scope of cardiovascular
pathology. This review focuses on the use of HUVECs as an in
vitro
model to evaluate different therapeutic approaches.

Anahtar Kelimeler

human umbilical vein endothelial cells, cardiovascular diseases, in vitro, models

Kaynakça

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