Year 2019, Volume 4, Issue 1, Pages 22 - 29 2019-05-16

The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture

Fazile Nur Ekinci Akdemir [1] , Ayhan Tanyeli [2]

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Aim: In this paper, it was presented the antioxidant effect of fraxin against acute organ damage by induced cecal ligation and puncture model in rats. Material and Methods: For this purpose in this study, all experimental animals were randomly grouped. These groups were stated as sham-control, CLP, CLP+Fraxin 50 mg/kg, CLP+Fraxin 100 mg/kg groups. TAS, TOS, OSI, MDA levels, MPO and SOD activities were evaluated in kidney and lung tissues of all rats. Results: TOS, OSI, MDA levels and MPO activity of kidney and lung tissues were higher in the CLP group than in the sham-control group, but TAS level and SOD activity were lower. However, these results were significantly changed in the fraxin treatment groups. Conclusion: In light of these results, it can be stated that fraxin shows a positive effect by raising the level of SOD and TAS by decreasing TOS, MPO and MDA levels on kidney and lung tissue in the model of sepsis caused by CLP.

Cecal ligation and puncture, fraxin, sepsis
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Primary Language tr
Subjects Science
Journal Section Volume IV, Issue I, 2019
Authors

Orcid: 0000-0001-9585-3169
Author: Fazile Nur Ekinci Akdemir (Primary Author)
Institution: AGRI IBRAHIM CECEN UNIVERSITY
Country: Turkey


Orcid: 0000-0002-0095-0917
Author: Ayhan Tanyeli
Institution: ATATURK UNIVERSITY
Country: Turkey


Dates

Publication Date: May 16, 2019

Bibtex @research article { tjos536056, journal = {Turkish Journal of Science}, issn = {2587-0971}, eissn = {2587-0971}, address = {KED Yayıncılık LTD ŞTİ.}, year = {2019}, volume = {4}, pages = {22 - 29}, doi = {}, title = {The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture}, key = {cite}, author = {Ekinci Akdemir, Fazile Nur and Tanyeli, Ayhan} }
APA Ekinci Akdemir, F , Tanyeli, A . (2019). The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture. Turkish Journal of Science, 4 (1), 22-29. Retrieved from http://dergipark.org.tr/tjos/issue/45237/536056
MLA Ekinci Akdemir, F , Tanyeli, A . "The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture". Turkish Journal of Science 4 (2019): 22-29 <http://dergipark.org.tr/tjos/issue/45237/536056>
Chicago Ekinci Akdemir, F , Tanyeli, A . "The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture". Turkish Journal of Science 4 (2019): 22-29
RIS TY - JOUR T1 - The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture AU - Fazile Nur Ekinci Akdemir , Ayhan Tanyeli Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Science JF - Journal JO - JOR SP - 22 EP - 29 VL - 4 IS - 1 SN - 2587-0971-2587-0971 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Science The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture %A Fazile Nur Ekinci Akdemir , Ayhan Tanyeli %T The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture %D 2019 %J Turkish Journal of Science %P 2587-0971-2587-0971 %V 4 %N 1 %R %U
ISNAD Ekinci Akdemir, Fazile Nur , Tanyeli, Ayhan . "The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture". Turkish Journal of Science 4 / 1 (May 2019): 22-29.
AMA Ekinci Akdemir F , Tanyeli A . The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture. TJOS. 2019; 4(1): 22-29.
Vancouver Ekinci Akdemir F , Tanyeli A . The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced Cecal Ligation and Puncture. Turkish Journal of Science. 2019; 4(1): 29-22.