Allerjik Hastalıkları olan Hastaların Deri Prik Testi Sonuçlarının Obezite, C-Reaktif Protein (CRP) ve Serum Total IgE ile ilişkisi
Öz
Amaç:
Alerjik hastalığı olan hastalarda cilt prick test sonuçları ile serum total
IgE, C-reaktif protein, vücut kitle indeksi arasındaki ilişkiyi değerlendirmek.
Metod:
Bu çalışma Ekim 2011 ile Eylül 2018 tarihleri arasında üniversite hastanesinde
yapıldı. Astım, alerjik rinit, kronik ürtiker ve atopik dermatit tanısı ile
başvuran göğüs hastalıkları kliniğindeki 433 hastaya deri prik testi (DPT)
uygulandı. Ayrıca hastaların serum total IgE, C-reaktif protein (CRP) düzeyleri
ve vücut kitle indeksi ölçümleri (BMI) değerlendirildi.
Bulgular:
Çalışma grubu 433 hastadan oluşmaktadır, 189'u (% 43,6) erkek, 244'ü (% 56,4)
kadındı. Tanıya göre 177 (% 40,9) hastada astım, 108 (% 24,9) hastada alerjik
rinit, 82 (% 18,9) hastada atopik dermatit ve 66'sında (% 15,2) kronik ürtiker
vardı. SPT 285 (% 65,8) hastada pozitif, 148 (% 34,2) hastada negatif bulundu.
En sık görülen alerjenler % 23.2, ev tozu% 19.2, vahşi çimenlerde% 14.8 ağaç
karışımıydı. DPT pozitif grupta total IgE, CRP ve BMI değerleri istatistiksel
olarak daha yüksekti. (P˂0.001). Obez hastalarda istatistiksel olarak anlamlı
pozitif deri prik sonuçları vardı (p = 0.036). Ayrıca pozitif total IgE ve CRP
grupları pozitif DPT grubunda anlamlı olarak daha yüksekti (p ˂0.001 ve p =
0.008). Total IgE düzeyleri ile DPT arasında orta düzeyde ve anlamlı pozitif
korelasyon vardı (r = 0.463, p˂0.001). Ayrıca CRP seviyeleri (r = 0.128, p =
0.008) ve obezite (r = 0.101, p = 0.036) düşük seviyede ve DPT ile anlamlı
pozitif korelasyon gösterdi. DPT için sadece total IgE istatistiksel olarak
anlamlı risk faktörü idi. Pozitif total IgE düzeyi, pozitif SPT olasılığını
8.11 kat arttırır.
Sonuç:
Bu çalışma, yüksek total IgE, CRP ve obezite düzeylerinin, pozitif deri prik
testi olasılığının artmasıyla atopi ile ilişkiye sahip olabileceğini
göstermektedir. Pozitif total IgE düzeyi, deri prik test pozitifliği için güçlü
bir prediktör olabilir.
Anahtar Kelimeler
Atopi; C-Reaktif Protein; Deri Prik Testi; Obezite; Total IgE
Destekleyen Kurum
Bulunmamaktadır
Kaynakça
- 1. Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue - an update. Horm Metab Res. 2007 May;39(5):314-21.2. Gorgievska-Sukarovska B, Lipozencić J, Susac A. Obesity and allergic diseases. Acta Dermatovenerol Croat. 2008; 16:231-5.3. Halvani A, Tahghighi F, Nadooshan HH. Evaluation of correlation between airway and serum inflammatory markers in asthmatic patients. Lung India. 2012 Apr;29(2):143-64. Butland BK, Strachan DP, Rudnicka AR. C-reactive protein, obesity, atopy and asthma symptoms in middle-aged adults. Eur Respir. 2008 Jul;32(1):77-84.5. Olafsdottir IS, Gislason T, Thjodleifsson B, et al. C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study. Thorax. 2005 Jun;60(6):451-4.6. Panaszek B, Liebhart E, Liebhart J, et al. Serum concentration of C-reactive protein is not a good marker of bronchial hyperresponsiveness. Arch Immunol Ther Exp (Warsz). 2007 Sep-Oct;55(5):341-5.7. Zureik M, Driss F, Neukirch C, Leynaert B, Neukirch F. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study. Thorax. 2004 Oct;59(10):892-6.Kony S, 8. Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004 May;113(5):832-6.9. Chang ML, Cui C, Liu YH, et al. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomed Rep. 2015 Jul;3(4):573-577.10. Lokaj-Berisha V, Gacaferri-Lumezi B, Minci-Bejtullahu G, et al. Gender Associated High Body Mass Index in Allergic Diseases. Open Access Maced J Med Sci. 2015 Mar 15;3(1):69-74.11. Chen Y, Rennie D, Cormier Y, Dosman J. Association between obesity and atopy in adults. Int Arch Allergy Immunol. 2010;153(4):372-7.12. Kasayama S, Tanemura M, Koga M, Fujita K, Yamamoto H, Miyatake A. Asthma is an independent risk for elevation of plasma C-reactive protein levels. Clin Chim Acta. 2009 Jan;399(1-2):79-82.13. Fujita M, Ueki S, Ito W, Chiba T, Takeda M, Saito N, Kayaba H, Chihara J. C-reactive protein levels in the serum of asthmatic patients. Ann Allergy Asthma Immunol. 2007 Jul;99(1):48-53.14. Wang J, Suárez-Fariñas M, Estrada Y, Parker ML, Greenlees L, Stephens G, Krueger J, Guttman-Yassky E, Howell MD. Identification of unique proteomic signatures in allergic and non-allergic skin disease. Clin Exp Allergy. 2017 Nov;47(11):1456-1467.15. Yang BY, Markevych I, Harris C, Standl M, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Dong GH, Heinrich J. High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents. Int Arch Allergy Immunol. 2019;179(2):152-157.16. Amina Hamed Ahmad Al Obaidi, Abdul Ghani Mohamed Al Samarai, Abdul Karem Yahya Jawad, Jasim Mohamed Al Janabi. Association Between C Reactive Protein and Asthma. Turk Thorac J 2010; 11: 98-104.17. Can evaluation of specific immunoglobulin E serum concentrations of antibodies to aeroallergens in atopic dermatitis patients replace skin prick tests method in clinical practice?. Jeziorkowska R, Rożalski M, Skowroński K, Samochocki Z. Postepy Dermatol Alergol. 2019 Aug;36(4):478-484.18. Feti Tülübaş, Ahmet Gürel, Mustafa Metin Donma, Burçin Nalbantoğlu, Birol Topçu, Zeynep Deniz Mut. Astma ve alerjik rinitli çocuklarda total IgE, C-reaktif protein ve kan sayım parametrelerinin değerlendirilmesi. Dicle Tıp Dergisi.2013;40(1):57-61.19. Lababidi HM, AlSowayigh OM, BinHowemel SF, AlReshaid KM, Alotaiq SA, Bahnassay AA. Refractory asthma phenotyping based on immunoglobulin E levels and eosinophilic counts: A real life study. Respir Med. 2019 Oct 6;158:55-58.
Association Between Obesity, C-Reactive Protein and Serum Total IgE with Skin Prick Test Results in Patients with Allergic Diseases
Öz
Objective:
To evaluate relationship between skin prick test results and serum total IgE,
C-reactive protein,
body mass index in patients with allergic diseases.
Material
and methods: This study was conducted in university
hospital between October 2011 and September 2018. Skin Prick test (SPT) was
applied to 433 patients in chest diseases clinic who were referred with
diagnosis of asthma, allergic rhinitis, chronic urticaria and atopic
dermatitis. Also patients’ serum total IgE, C-reactive protein (CRP) levels and
body mass index (BMI) measurements were evaluated.
Results:
The study group were consisted of 433 patients, 189 (43.6%) male, and 244[G1]
(56.4%) female. According to the diagnosis, 177 (40.9%) patients had asthma,
108 (24.9%) had allergic rhinitis, 82(18.9%) had atopic dermatitis and 66
(15.2%) had chronic urticaria. SPT was positive in 285 (65.8%) patients while
negative in 148(34.2%). Most frequently seen allergens were the mixture of
trees 23.2%, home dust 19.2%, savage grass 14.8%. Total IgE, CRP, and BMI
values were statistically higher in SPT positive group. (p[G2] ˂0.001).
Obese patients had statistically significant positive skin prick results
(p=0.036). Also, positive total IgE and CRP groups were significantly higher in
positive SPT group (p ˂0.001 and
p=0.008). There was a moderate level and
significant positive correlation between total IgE levels and SPT (r=0.463,
p˂0.001). Also CRP levels (r= 0.128, p=0.008) and obesity (r=0.101, p=0.036) had a low level and
significant positive correlation with SPT. Only total IgE was the statistically
significant risk factor for [G3] the
SPT.[G4]
Positive total IgE level increases the probability of positive SPT by 8.11
times.
Conclusion:
This
study suggests that elevated levels of total IgE, CRP and obesity may have
relationship with atopy by increased likelihood of positive skin prick test.
Positive Total IgE level can be a strong predictor for skin prick test
positivity.
Anahtar Kelimeler
Atopy; C-Reactive Protein; Obesity; Skin Prick Test; Total IgE
Kaynakça
- 1. Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue - an update. Horm Metab Res. 2007 May;39(5):314-21.2. Gorgievska-Sukarovska B, Lipozencić J, Susac A. Obesity and allergic diseases. Acta Dermatovenerol Croat. 2008; 16:231-5.3. Halvani A, Tahghighi F, Nadooshan HH. Evaluation of correlation between airway and serum inflammatory markers in asthmatic patients. Lung India. 2012 Apr;29(2):143-64. Butland BK, Strachan DP, Rudnicka AR. C-reactive protein, obesity, atopy and asthma symptoms in middle-aged adults. Eur Respir. 2008 Jul;32(1):77-84.5. Olafsdottir IS, Gislason T, Thjodleifsson B, et al. C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study. Thorax. 2005 Jun;60(6):451-4.6. Panaszek B, Liebhart E, Liebhart J, et al. Serum concentration of C-reactive protein is not a good marker of bronchial hyperresponsiveness. Arch Immunol Ther Exp (Warsz). 2007 Sep-Oct;55(5):341-5.7. Zureik M, Driss F, Neukirch C, Leynaert B, Neukirch F. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study. Thorax. 2004 Oct;59(10):892-6.Kony S, 8. Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004 May;113(5):832-6.9. Chang ML, Cui C, Liu YH, et al. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomed Rep. 2015 Jul;3(4):573-577.10. Lokaj-Berisha V, Gacaferri-Lumezi B, Minci-Bejtullahu G, et al. Gender Associated High Body Mass Index in Allergic Diseases. Open Access Maced J Med Sci. 2015 Mar 15;3(1):69-74.11. Chen Y, Rennie D, Cormier Y, Dosman J. Association between obesity and atopy in adults. Int Arch Allergy Immunol. 2010;153(4):372-7.12. Kasayama S, Tanemura M, Koga M, Fujita K, Yamamoto H, Miyatake A. Asthma is an independent risk for elevation of plasma C-reactive protein levels. Clin Chim Acta. 2009 Jan;399(1-2):79-82.13. Fujita M, Ueki S, Ito W, Chiba T, Takeda M, Saito N, Kayaba H, Chihara J. C-reactive protein levels in the serum of asthmatic patients. Ann Allergy Asthma Immunol. 2007 Jul;99(1):48-53.14. Wang J, Suárez-Fariñas M, Estrada Y, Parker ML, Greenlees L, Stephens G, Krueger J, Guttman-Yassky E, Howell MD. Identification of unique proteomic signatures in allergic and non-allergic skin disease. Clin Exp Allergy. 2017 Nov;47(11):1456-1467.15. Yang BY, Markevych I, Harris C, Standl M, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Dong GH, Heinrich J. High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents. Int Arch Allergy Immunol. 2019;179(2):152-157.16. Amina Hamed Ahmad Al Obaidi, Abdul Ghani Mohamed Al Samarai, Abdul Karem Yahya Jawad, Jasim Mohamed Al Janabi. Association Between C Reactive Protein and Asthma. Turk Thorac J 2010; 11: 98-104.17. Can evaluation of specific immunoglobulin E serum concentrations of antibodies to aeroallergens in atopic dermatitis patients replace skin prick tests method in clinical practice?. Jeziorkowska R, Rożalski M, Skowroński K, Samochocki Z. Postepy Dermatol Alergol. 2019 Aug;36(4):478-484.18. Feti Tülübaş, Ahmet Gürel, Mustafa Metin Donma, Burçin Nalbantoğlu, Birol Topçu, Zeynep Deniz Mut. Astma ve alerjik rinitli çocuklarda total IgE, C-reaktif protein ve kan sayım parametrelerinin değerlendirilmesi. Dicle Tıp Dergisi.2013;40(1):57-61.19. Lababidi HM, AlSowayigh OM, BinHowemel SF, AlReshaid KM, Alotaiq SA, Bahnassay AA. Refractory asthma phenotyping based on immunoglobulin E levels and eosinophilic counts: A real life study. Respir Med. 2019 Oct 6;158:55-58.