Araştırma Makalesi
Yıl 2019,
Cilt: 4 Sayı: 2, 51 - 56, 31.12.2019
Öz
Destekleyen Kurum
BURDUR MEHMET AKİF ERSOY ÜNİVERSİTESİ
Proje Numarası
0540-YL-18
Teşekkür
Bu araştırma Mehmet Akif Ersoy Üniversitesi Bilimsel Araştırma projeleri Koordinatörlüğü tarafından 0540-YL-18 proje numarası ile desteklenmiştir. Desteklerinden dolayı Mehmet Akif Ersoy Üniversitesi'ne teşekkür ederiz.
Kaynakça
- KAYNAKLAR 1- Addie D, Belák S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E, Truyen U, Horzinek MC. Feline infectious peritonitis. ABCD guidelines on prevention and management. J Feline Med Surg. 2009; 11(7):594-604. 2- Al Muhairi S, Al Hosani F, Eltahir YM, Al Mulla M, Yusof MF, Serhan WS, Hashem FM, Elsayed EA, Marzoug BA, Abdelazim AS. Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate, United Arab Emirates. Virus Genes, 2016; 52:848–854. 3- Decaro N, Buonavoglia C. Canine Coronavirus: Not Only an Enteric Pathogen Vet Clin Small Anim. 2011; 41: 1121–1132. 4- Dhama K, Pawaiya KRVS, Chakraborty S, Tiwari R, Saminathan M, Verma AK (2014): Coronavirus Infection in Equines. A Review Asian Journal of Animal and Veterinary Advances. 2014;9 (3):164-176. 5- Fehr AR, Perlman S. Coronaviruses: An Overview of Their Replication and Pathogenesis. Methods Mol Biol. 2015; 1282, 1–23. 6- Pedersen NC. An update on feline infectious peritonitis: virology and immunopathogenesis. Vet J. 2014; 201(2):123-32. 7- Oma VS, Tråvén M, Alenius S, Myrmel M, Stokstad M. Bovine coronavirus in naturally and experimentally exposed calves; viral shedding and the potential for transmission. Virol J. 2016; 13: 100. 8- Elliott P. Coronavirus in Dogs, Symptoms and Treatment. Petful, http://www.petful.com/pet-health/2016. 9- Navarro R, Nair R, Peda A, Aung MS, Ashwinie GS, Gallagher CA, Malik YS, Kobayashi N, Ghosh S. Molecular characterization of canine parvovirus and canine enteric coronavirus in diarrheic dogson the island of St. Kitts: First report from the Caribbean region. Virus Res. 2017; 15 (240):154-160. 10- Mackay IM, Arden KE. MERS coronavirus: diagnostics, epidemiology and transmission. Virol J. 2015; 12: 222. 11- Niederwerder MC, Hesse RA. Swine enteric coronavirus disease: A review of 4 years with porcine epidemic diarrhoea virus and porcine delta coronavirus in the United States and Canada. Transbound Emerg Dis. 2018; 65(3):660-675. 12- Sharif S, Arshad SS, Hair-Bejo M, Omar AR, Zeenathul NA, Hafidz MA. Prevalence of feline coronavirus in two cat populations in Malaysia. J Feline Med Surg. 2009; 11(12):1031-4. 13- Belouzard S, Millet JK, Licitra BN, Whittaker GR. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses, 2012; 4(6):1011-33. 14- Carlson KJ and Macintire DK. Feline infectious peritonitis. Emergency and Critical Care Medicine,2006; 8(1):1-11. 15- Li C, Liu Q, Kong F, Guo D, Zhai J, Su M, Sun D. Circulation and genetic diversity of Feline coronavirus type I and II from clinically healthy and FIP-suspected cats in China. Transbound Emerg Dis. 2018; 66(2):763-775. 16- Bell ET, Toribio JA, White JD, Malik R, Norris JM. Seroprevalence study of feline coronavirus in owned and feral cats in Sydney, Australia. Aust Vet J. 2006; 84(3),74-81. 17- Jinks MR, English RV, Gilger BC. Causes of endogenous uveitis in cats presented to referral clinics in North Carolina. 2006; Vet Ophthalmol, 1: 30-7. 18- Oğuzoğlu TÇ, Sahna KC, Ataseven VS, Muz D. Prevalence of feline coronavirus (FCoV) and feline leukemia virus (FeLV) in Turkish cats. Ankara Üniv Vet Fak Derg, 2010; 57: 271-274. 19- Taharaguchi S, Soma T, Hara M. Prevalence of feline coronavirus antibodies in Japanese domestic cats during the past decade. J Vet Med Sci. 2012; 74(10):1355-8. 20- Worthing, K., Wigney, D., Dhand, N., Fawcett, Q.A., McDonagh, P., Malik, K.R., Norris, J. Risk factors for feline infectious peritonitis in Australian cats. J. Feline Med. Surg.2012; 14:405–412. 21- Soma T, Saito N, Kawaguchi M, Sasai K. Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs. J Vet Med Sci.2018; 80(1): 59– 62. 22- Vennema H, Poland A, Foley J, Pedersen NC. Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. Virology, 1998; 243:150-157. 23- Aytuğ N. Kedi İnfeksiyonları 1: Zorlayan Tanı; Kedilerin Enfeksiyöz Peritonitisi, Uludag Univ. J. Fac. Vet. Med, 2008; 27(1-2): 11-17. 24- Barr MC, Olsen CW, Scott FW. Feline viral diseases. In: Ettinger SJ Feldman EC eds.Veterinary internal medicine 4th ed. Philadelphia: saunders, 1995;409-439. 25- Jeffery U, Deitz K and Hostetter S. Positive predictive value of albumin: globulin ratio for feline infectious peritonitis in a mid-western referral hospital population. J Feline Med Surg. 2012; 14(12); 903-905. 26- Knowles TG, Edwards JE, Bazeley KJ, Brown SN, Butterworth A, Warriss RD. Changes in the blood biochemical and haematological profile of neonatal calves with age. Veterinary Record., 2000; 147: 593-598. 27- Rastawicki W, Paradowska-Stankiewicz I, Stefanoff P, Zasada AA. Reliability of the cut-off value in the routine serodiagnosis of pertussis performed by the commercial ELISA assays. Med Dosw Mikrobiol. 2011; 63:73-80. 28- Sharma B, Jain R. Right choice of a method for determination of cut-off values: A statistical tool for a diagnostic test. Asian Jurnal of Medical Science. 2014; 5:30- 34. 29- Singh M, Gupta VK, Mondal DB, Bansal SK, Sharma DK, Shakya M, Gopinath D. A study on alteration in haemato-biochemical parameters in Colibacillosis affected calves. International Journal of Advanced Research. 2014; 2:746-750. 30- Takano, T., Azuma, N., Satoh, M., Toda, A., Hashida, Y., Satoh, R., Hohdatsu, T. Neutrophil survival factors (TNF-alpha, GM-CSF, and GCSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions. Arch Virol 2009; 154(5), 775-81. 31- De Groot-Mijnes JD, van Dun JM, van der Most RG, de Groot RJ. Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease. J Virol. 2005; 79(2):1036-44. 32- Paltrinieri S, Cammarata MP, Cammarata G, Comazzi S. Laboratory Changes Consistent with Feline Infectious Peritonitis in Cats from Multicat Environments. J. Vet. Med. Series A. 2002; 49(19):503-510
Feline infeksiyöz peritonitisli kedilerde bazı hematolojik ve biyokimyasal Parametrelerin Araştırılması
Öz
Araştırmanın
amacı felin infeksiyöz peritonitisli (FİP) kedilerde bazı biyokimyasal ve
hematolojik parametrelerin araştırılmasıdır. Ayrıca kuru form ve yaş from
FİP’li kediler arasında analiz edilen bu parameterlerde farlılıkların
belirlenmesi de hedeflenmiştir. Çalışmada klinik belirtiler gösteren, sadece Feline
Coronavirus (FCoV) Ag veya FCoV Ab pozitif olan 20 adet (çalışma grubu) ve
klinik olarak sağlıklı tüm testlerden negatif olan 10 adet (kontrol grubu) kedi
kullanıldı. Ayrıca, klinik ve nekropsi bulguları ışığında 20 FİP’li kedi eşit
olarak kuru ve yaş from FİP’li olarak iki gruba ayrıldı. Bu hayvanların klinik
muayeneleri, hematolojik ve biyokimyasal analizleri yapılarak elde edilen
değerler kayıt altına alındı. Çalışmada, yapılan klinik muayenede FİP’li kedilerin sadece solunum sayılarının kontrol
grubuna göre daha yüksek olduğu (p<0,01), kalp frekansı ve rektal
derecelerinde ise önemli farklılıkların olmadığı belirlenmiştir. Yapılan
hematolojik analizler sonucunda FİP’li kedilerin total lökosit (WBC)
(p<0,01), granulosit (p<0,01) ve monosit (p<0,01) sayılarında kontrol
grubuna göre önemli düzeyde artışların olduğu buna karşın total eritrosit
(p<0,01) ve lenfosit sayıları (p<0,05) ile hemoglobin (HGB) konsantasyonlarının
(p<0,05) ise kontrol grubuna göre anlamlı düzeyde düşük olduğu saptanmıştır. Biyokimyasal analizler
sonucunda FİP’li kedilerin alanin aminotransferaz (ALT) (p<0,01), laktat
dehidrojenaz (LDH) (p<0,05), alkalen fosfotaz (ALP) (p<0,05), total bilirubin
(TB) (p<0,01), total protein (TP) (p<0,05) ve globülin (G) (p<0,001)
değerlerinin kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek,
albumin (A) (p<0,05) ve A/G (p<0,001) oranının ise daha düşük olduğu
saptandı. Kuru formda bulunan kedilerin
BUN, TP, A, G değerlerinin yaş formda bulunan kedilerin değerlerine göre daha
yüksek, A/G oranının ise daha düşük olduğu belirlendi. Sonuç olarak, bu çalışmada elde edilen bulgular
FİP’li kedilerin hematopoetik sistemi yanında karaciğer ve böbrek fonksiyonlarınında
bu infeksiyondan negatif yönde etkilendiğini ortaya koymaktadır.
Anahtar Kelimeler
Proje Numarası
0540-YL-18
Kaynakça
- KAYNAKLAR 1- Addie D, Belák S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E, Truyen U, Horzinek MC. Feline infectious peritonitis. ABCD guidelines on prevention and management. J Feline Med Surg. 2009; 11(7):594-604. 2- Al Muhairi S, Al Hosani F, Eltahir YM, Al Mulla M, Yusof MF, Serhan WS, Hashem FM, Elsayed EA, Marzoug BA, Abdelazim AS. Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate, United Arab Emirates. Virus Genes, 2016; 52:848–854. 3- Decaro N, Buonavoglia C. Canine Coronavirus: Not Only an Enteric Pathogen Vet Clin Small Anim. 2011; 41: 1121–1132. 4- Dhama K, Pawaiya KRVS, Chakraborty S, Tiwari R, Saminathan M, Verma AK (2014): Coronavirus Infection in Equines. A Review Asian Journal of Animal and Veterinary Advances. 2014;9 (3):164-176. 5- Fehr AR, Perlman S. Coronaviruses: An Overview of Their Replication and Pathogenesis. Methods Mol Biol. 2015; 1282, 1–23. 6- Pedersen NC. An update on feline infectious peritonitis: virology and immunopathogenesis. Vet J. 2014; 201(2):123-32. 7- Oma VS, Tråvén M, Alenius S, Myrmel M, Stokstad M. Bovine coronavirus in naturally and experimentally exposed calves; viral shedding and the potential for transmission. Virol J. 2016; 13: 100. 8- Elliott P. Coronavirus in Dogs, Symptoms and Treatment. Petful, http://www.petful.com/pet-health/2016. 9- Navarro R, Nair R, Peda A, Aung MS, Ashwinie GS, Gallagher CA, Malik YS, Kobayashi N, Ghosh S. Molecular characterization of canine parvovirus and canine enteric coronavirus in diarrheic dogson the island of St. Kitts: First report from the Caribbean region. Virus Res. 2017; 15 (240):154-160. 10- Mackay IM, Arden KE. MERS coronavirus: diagnostics, epidemiology and transmission. Virol J. 2015; 12: 222. 11- Niederwerder MC, Hesse RA. Swine enteric coronavirus disease: A review of 4 years with porcine epidemic diarrhoea virus and porcine delta coronavirus in the United States and Canada. Transbound Emerg Dis. 2018; 65(3):660-675. 12- Sharif S, Arshad SS, Hair-Bejo M, Omar AR, Zeenathul NA, Hafidz MA. Prevalence of feline coronavirus in two cat populations in Malaysia. J Feline Med Surg. 2009; 11(12):1031-4. 13- Belouzard S, Millet JK, Licitra BN, Whittaker GR. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses, 2012; 4(6):1011-33. 14- Carlson KJ and Macintire DK. Feline infectious peritonitis. Emergency and Critical Care Medicine,2006; 8(1):1-11. 15- Li C, Liu Q, Kong F, Guo D, Zhai J, Su M, Sun D. Circulation and genetic diversity of Feline coronavirus type I and II from clinically healthy and FIP-suspected cats in China. Transbound Emerg Dis. 2018; 66(2):763-775. 16- Bell ET, Toribio JA, White JD, Malik R, Norris JM. Seroprevalence study of feline coronavirus in owned and feral cats in Sydney, Australia. Aust Vet J. 2006; 84(3),74-81. 17- Jinks MR, English RV, Gilger BC. Causes of endogenous uveitis in cats presented to referral clinics in North Carolina. 2006; Vet Ophthalmol, 1: 30-7. 18- Oğuzoğlu TÇ, Sahna KC, Ataseven VS, Muz D. Prevalence of feline coronavirus (FCoV) and feline leukemia virus (FeLV) in Turkish cats. Ankara Üniv Vet Fak Derg, 2010; 57: 271-274. 19- Taharaguchi S, Soma T, Hara M. Prevalence of feline coronavirus antibodies in Japanese domestic cats during the past decade. J Vet Med Sci. 2012; 74(10):1355-8. 20- Worthing, K., Wigney, D., Dhand, N., Fawcett, Q.A., McDonagh, P., Malik, K.R., Norris, J. Risk factors for feline infectious peritonitis in Australian cats. J. Feline Med. Surg.2012; 14:405–412. 21- Soma T, Saito N, Kawaguchi M, Sasai K. Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs. J Vet Med Sci.2018; 80(1): 59– 62. 22- Vennema H, Poland A, Foley J, Pedersen NC. Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. Virology, 1998; 243:150-157. 23- Aytuğ N. Kedi İnfeksiyonları 1: Zorlayan Tanı; Kedilerin Enfeksiyöz Peritonitisi, Uludag Univ. J. Fac. Vet. Med, 2008; 27(1-2): 11-17. 24- Barr MC, Olsen CW, Scott FW. Feline viral diseases. In: Ettinger SJ Feldman EC eds.Veterinary internal medicine 4th ed. Philadelphia: saunders, 1995;409-439. 25- Jeffery U, Deitz K and Hostetter S. Positive predictive value of albumin: globulin ratio for feline infectious peritonitis in a mid-western referral hospital population. J Feline Med Surg. 2012; 14(12); 903-905. 26- Knowles TG, Edwards JE, Bazeley KJ, Brown SN, Butterworth A, Warriss RD. Changes in the blood biochemical and haematological profile of neonatal calves with age. Veterinary Record., 2000; 147: 593-598. 27- Rastawicki W, Paradowska-Stankiewicz I, Stefanoff P, Zasada AA. Reliability of the cut-off value in the routine serodiagnosis of pertussis performed by the commercial ELISA assays. Med Dosw Mikrobiol. 2011; 63:73-80. 28- Sharma B, Jain R. Right choice of a method for determination of cut-off values: A statistical tool for a diagnostic test. Asian Jurnal of Medical Science. 2014; 5:30- 34. 29- Singh M, Gupta VK, Mondal DB, Bansal SK, Sharma DK, Shakya M, Gopinath D. A study on alteration in haemato-biochemical parameters in Colibacillosis affected calves. International Journal of Advanced Research. 2014; 2:746-750. 30- Takano, T., Azuma, N., Satoh, M., Toda, A., Hashida, Y., Satoh, R., Hohdatsu, T. Neutrophil survival factors (TNF-alpha, GM-CSF, and GCSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions. Arch Virol 2009; 154(5), 775-81. 31- De Groot-Mijnes JD, van Dun JM, van der Most RG, de Groot RJ. Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease. J Virol. 2005; 79(2):1036-44. 32- Paltrinieri S, Cammarata MP, Cammarata G, Comazzi S. Laboratory Changes Consistent with Feline Infectious Peritonitis in Cats from Multicat Environments. J. Vet. Med. Series A. 2002; 49(19):503-510
Toplam 1 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Proje Numarası | 0540-YL-18 |
| Yayımlanma Tarihi | 31 Aralık 2019 |
| Gönderilme Tarihi | 5 Eylül 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 4 Sayı: 2 |
