Araştırma Makalesi
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Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels

Yıl 2020, Cilt: 4 Sayı: 1, 10 - 15, 02.03.2020
https://doi.org/10.30565/medalanya.569972

Öz

Aim: To evaluate the scrotal melanin density in infants using spectrometry and to determine the correlation between spectrometric evaluations, physical examinations and blood 17-hydroxyprogesterone levels.

Material and methods: A total of 40 infants were enrolled to the study, 22 of whom were diagnosed by a physician as having scrotal hyperpigmentation and 18 with normal scrotal pigmentation, who were admitted for the evaluation of prolonged jaundice. Age, gestational week, birth weight and scrotal pigmentation noted by the physician were recorded. Spectral data were acquired from scrotum and thigh. A correlation between the spectral measurements and the blood 17-hydroxyprogesterone level was determined by comparing spectral value in the wavelength range of 620-800 nm and 17-hydroxyprogesterone levels.

Results: No statistically significant difference was observed between the groups who were categorized by the physician as having “hyperpigmented” or “normal” scrotal color in terms of the infant’s age, gestational week, birth weight, 17-hydroxyprogesterone level or spectrometric values. We observed a strong correlation between 17-hydroxyprogesterone levels and spectrometric values in all groups.

Conclusion: This preliminary study is the first one in the literature which evaluates scrotal pigmentation with an objective spectrometric method and determines its relationship with 17-hydroxyprogesterone levels. Further studies are needed to employ this method as a non-invasive, indirect screening test for the screening of congenital adrenal hyperplasia in male infants.

Destekleyen Kurum

Akdeniz University Scientific Research Unit, Antalya, Turkey

Proje Numarası

2014.04.0103.005

Kaynakça

  • 1. El-Maouche D, Arlt W, Merke DP. Congenital adrenal hyperplasia. Lancet. 2017;390(10108):2194-2210 PMID: 28576284
  • 2. Speiser PW, Azziz R, Baskin LS, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95(9):4133–60. PMID: 20823466
  • 3. Merke DP, Bornstein SR. Congenital adrenal hyperplasia. Lancet. 2005;365(9477):2125-36. PMID: 15964450
  • 4. Karakas BR, Sircan-Kucuksayan A, Elpek OG, Canpolat M. Investigating viability of intestine using spectroscopy: a pilot study. J Surg Res. 2014;191(1):91-8. PMID: 24746953
  • 5. Sircan-Kucuksayan A, Uyuklu M, Canpolat M. Diffuse reflectance spectroscopy for measurement of tissue oxygen saturation. Physiol Meas. 2015;36(12):2461–69. PMID: 26536251
  • 6. Turhan M, Yaprak N, Sircan-Kucuksayan A, et al. Intraoperative Assessment of Laryngeal Malignancy Using Elastic Light Single-Scattering Spectroscopy: A Pilot Study. Laryngoscope. 2017;127(3):611-15. PMID: 27545013
  • 7. Sircan-Kuçuksayan A, Denkceken T, Canpolat M. Differentiating cancerous tissues from noncancerous tissues using single-fiber reflectance spectroscopy with different fiber diameters J Biomed Opt. 2015;20(11):115007 PMID: 26590218
  • 8. Sircan-Kucuksayan A, Canpolat M. Retrieval of Chromophore Concentration in a Tissue Phantom by Diffuse Reflectance Spectroscopy. Optics and Spectroscopy. 2014;117:663–9.
  • 9. Saager RB, Cuccia DJ, Durkin AJ. Determination of optical properties of turbid media spanning visible and near-infrared regimes via spatially modulated quantitative spectroscopy. J Biomed Opt. 2010;15(1):017012. PMID: 20210486
  • 10. White PC. Neonatal screening for congenital adrenal hyperplasia. Nat Rev Endocrinol. 2009;5(9):490-8. PMID: 19690561
  • 11. Thil'en A, Nordenström A, Hagenfeldt L, von Döbeln U, Guthenberg C, Larsson A. Benefits of neonatal screening for congenital adrenal hyperplasia (21-hydroxylase deficiency) in Sweden. Pediatrics. 1998;101(4):E11. PMID: 9521977
  • 12. Homma K, Hasegawa T, Takeshita E, et al. Elevated urine pregnanetriolone definitively establishes the diagnosis of classical 21-hydroxylase deficiency in term and preterm neonates. J Clin Endocrinol Metab. 2004;89(12):6087-91. PMID: 15579762
  • 13. Van der Kamp HJ. Cutoff levels of 17-α-hydroxyprogesterone in neonatal screening for congenital adrenal hyperplasia should be based on gestational age rather than on birth weight. J Clin Endocrinol Metab. 2005;90(7):3904-7. PMID: 15797960
  • 14. Gökdemir G, Erdoğan HK, Köşlü A, Baksu B. Cutaneous lesions in Turkish neonates born in a teaching hospital. Indian J Dermatol Venereol Leprol. 2009; 75(6): 638. PMID: 19915262

Yenidoğanlarda skrotal pigmentasyonun spektrometre ile değerlendirilmesi ve 17-hidroksiprogesteron kan düzeyi ile korelasyonunun incelenmesi

Yıl 2020, Cilt: 4 Sayı: 1, 10 - 15, 02.03.2020
https://doi.org/10.30565/medalanya.569972

Öz

Amaç: Spektrometre ile bebeklerin skrotal melanin dansitesini değerlendirmek ve spektrometrik değerlendirme ile fizik muayene ve kan 17-hidroksiprogesteron düzeyleri arasındaki ilişkiyi belirlemektir.

Gereç ve Yöntemler: Çalışmaya skrotal hiperpigmentasyonu olduğu düşünülen 22 olgu ile uzamış sarılık nedeniyle başvuran normal skrotal pigmentasyona sahip 18 olgu olmak üzere toplam 40 bebek dahil edildi. Olguların yaşı, gestasyon haftası, doğum ağırlığı, anne yaşı, skrotum rengi kayıt altına alındı. Spektral veriler skrotumdan ve uyluktan elde edildi. Spektral ölçümler ve kan 17- hidroksiprogesteron seviyesi arasındaki korelasyon, 620-800 nm dalga boyu aralığındaki spektral değer ve 17- hidroksiprogesteron seviyelerinin karşılaştırılmasıyla incelendi.

Bulgular: Skrotal hiperpigmentasyonu saptanan ve saptanmayan grup arasında anne-olgu yaşı, gestasyon haftası, doğum ağırlığı, 17-hidroksiprogesteron düzeyi ve spektrometri değeri arasında istatistiksel olarak anlamlı farklılık saptanmadı. Tüm gruplarda 17-hidroksiprogesteron düzeyleri ile spektrometrik değerler arasında güçlü bir korelasyon gözlemledik.

Sonuç: Çalışmamız, literatürde spektrometre değerleriyle skrotal pigmentasyonun nesnel bir ölçüt hale getirildiği, 17-hidroksiprogesteron ile ilişkisinin incelendiği, gelecekte erkek bebeklerde konjenital adrenal hiperplazi taramasına dolaylı yoldan yardımcı olabilecek bir çalışmadır.

Proje Numarası

2014.04.0103.005

Kaynakça

  • 1. El-Maouche D, Arlt W, Merke DP. Congenital adrenal hyperplasia. Lancet. 2017;390(10108):2194-2210 PMID: 28576284
  • 2. Speiser PW, Azziz R, Baskin LS, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95(9):4133–60. PMID: 20823466
  • 3. Merke DP, Bornstein SR. Congenital adrenal hyperplasia. Lancet. 2005;365(9477):2125-36. PMID: 15964450
  • 4. Karakas BR, Sircan-Kucuksayan A, Elpek OG, Canpolat M. Investigating viability of intestine using spectroscopy: a pilot study. J Surg Res. 2014;191(1):91-8. PMID: 24746953
  • 5. Sircan-Kucuksayan A, Uyuklu M, Canpolat M. Diffuse reflectance spectroscopy for measurement of tissue oxygen saturation. Physiol Meas. 2015;36(12):2461–69. PMID: 26536251
  • 6. Turhan M, Yaprak N, Sircan-Kucuksayan A, et al. Intraoperative Assessment of Laryngeal Malignancy Using Elastic Light Single-Scattering Spectroscopy: A Pilot Study. Laryngoscope. 2017;127(3):611-15. PMID: 27545013
  • 7. Sircan-Kuçuksayan A, Denkceken T, Canpolat M. Differentiating cancerous tissues from noncancerous tissues using single-fiber reflectance spectroscopy with different fiber diameters J Biomed Opt. 2015;20(11):115007 PMID: 26590218
  • 8. Sircan-Kucuksayan A, Canpolat M. Retrieval of Chromophore Concentration in a Tissue Phantom by Diffuse Reflectance Spectroscopy. Optics and Spectroscopy. 2014;117:663–9.
  • 9. Saager RB, Cuccia DJ, Durkin AJ. Determination of optical properties of turbid media spanning visible and near-infrared regimes via spatially modulated quantitative spectroscopy. J Biomed Opt. 2010;15(1):017012. PMID: 20210486
  • 10. White PC. Neonatal screening for congenital adrenal hyperplasia. Nat Rev Endocrinol. 2009;5(9):490-8. PMID: 19690561
  • 11. Thil'en A, Nordenström A, Hagenfeldt L, von Döbeln U, Guthenberg C, Larsson A. Benefits of neonatal screening for congenital adrenal hyperplasia (21-hydroxylase deficiency) in Sweden. Pediatrics. 1998;101(4):E11. PMID: 9521977
  • 12. Homma K, Hasegawa T, Takeshita E, et al. Elevated urine pregnanetriolone definitively establishes the diagnosis of classical 21-hydroxylase deficiency in term and preterm neonates. J Clin Endocrinol Metab. 2004;89(12):6087-91. PMID: 15579762
  • 13. Van der Kamp HJ. Cutoff levels of 17-α-hydroxyprogesterone in neonatal screening for congenital adrenal hyperplasia should be based on gestational age rather than on birth weight. J Clin Endocrinol Metab. 2005;90(7):3904-7. PMID: 15797960
  • 14. Gökdemir G, Erdoğan HK, Köşlü A, Baksu B. Cutaneous lesions in Turkish neonates born in a teaching hospital. Indian J Dermatol Venereol Leprol. 2009; 75(6): 638. PMID: 19915262
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Abdurrahman Erdem Basaran 0000-0002-9092-6936

Aslınur Sırcan-küçüksayan 0000-0002-4168-8564

Murat Canpolat Bu kişi benim 0000-0003-3298-9725

Sevtap Velipasaoğlu Bu kişi benim 0000-0002-0200-8079

Proje Numarası 2014.04.0103.005
Yayımlanma Tarihi 2 Mart 2020
Gönderilme Tarihi 24 Mayıs 2019
Kabul Tarihi 10 Ekim 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 4 Sayı: 1

Kaynak Göster

Vancouver Basaran AE, Sırcan-küçüksayan A, Canpolat M, Velipasaoğlu S. Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels. Acta Med. Alanya. 2020;4(1):10-5.

9705 

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