Öz
Objective: The role of inflammation in the deep venous thrombosis (DVT) process has been explained in various studies. Hence, the role of inflammatory markers in this illness has been researched previouslyin the literature. Recent years, such as parameters, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), among complete blood count have been frequently started to use as an expression of inflammatory marker. In the current study, the relation between complete blood count parameters and DVT was investigated. Methods: 50 patients admitted to our clinic with the diagnosis of acute DVT (28 female, 22 male) were included in the study. The patients were diagnosed by clinical symptoms and Doppler USG. Patients with additional illness that can form an inflammatory response were excluded. 30 healthy volunteers were included as a control group. Routine complete blood counts of these patients were examined retrospectively. Routine complete blood counts and nonselective inflammatory markers, red cell distribution width (RDW), white cells (WBC), NLR, and PLR measurements were examined statistically. Results: The mean age of patients included in study was 46.2±14.2 and 53% of them were female. When the groups were examined in terms of hematological parameters, lymphocyte (2.6±0.8 and 2.1±0.7, p=0.003) and platelet (322±144 and 264±66, p=0.042) values were detected to be higher. Hemoglobin (13.2±2.0 and 14.6±1.5, p=0.002) and hematocrit (38.7±5.1 and 42.8±6.9, p
Anahtar Kelimeler
Complete blood count deep vein thrombosis platelet lymphocyte ratio neutrophil lymphocyte ratio
Kaynakça
- Heit JA. Venouse thromboembolism: disease burden, out- comes and risk factors. J Thromb Haemost 2005;3:1611– 1617.
- Nielsen JD. The incidence of pulmonary embolism during deep vein thrombosis. Phlebology 2013;28 Suppl 1:29-33.
- Karabinos I, Koulouris S, Kranidis A, Pastromas S, Exa- daktylos N, Kalofoutis A. Neutrophil count on admission predicts major in-hospital events in patients with a non-ST- segment elevation acute coronary syndrome. Clin Cardiol 2009;32:561-568.
- Reiter M, Bucek RA, Koca N, Dirisamer A, Minar E. Deep vein thrombosis and systemic inflammatory response: a pi- lot trial. Wien Klin Wochenschr 2003;115:111-114.
- Bucek RA, Reiter M, Quehenberger P, Minar E. C-reactive protein in the diagnosis of deep vein thrombosis. Br J Hae- matol. 2002;119:385-389.
- Culmer DL, Diaz JA, Hawley AE, et al. Circulating and vein wall P-selectin promote venous thrombogenesis during ag- ing in a rodent model. Thromb Res 2013;131:42-8.
- Roumen-Klappe EM, den Heijer M, van Uum SH, et al. In- flammatory response in the acute phase of deep vein throm- bosis. J Vasc Surg 2002;35:701-706.
- Wakefield TW, Strieter RW, Schaub R, et al. Venous throm- bosis prophylaxis by inflammatory inhibition without anti- coagulation therapy.Journal Of Vascular Surgery February 2000;31:309-324.
- Bucek RA, Reiter M, Quehenberger P, et al. C-reactive pro- tein in the diagnosis of deep vein thrombosis. Br J Haema- tol 2002;119:385-389.
- Bhat T, Teli S, Rijal J et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardio- vasc Ther 2013;11:55-9.
- Gary T, Pichler M, Belaj K, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in pe- ripheral arterial occlusive disease patients. PLoS One 2013;8:e67688
- White RH. The epidemiology of venous thromboembolism. Circulation 2003;107:I4-8.
- Lamping DL. Measuring health-related quality of life in venous disease: practical and scientific considerations. An- giology 1997;48:51-57.
- Çırak Y, Savcı S, Karahan Z, et al. Akut derin ven trom- bozu sonrası yaşam kalitesi: VEINES-QOL/Sym ölçeğinin kültürel adaptasyonu, güvenirliği ve geçerliği: Türkçe versiyon çalışması. Turk Gogus Kalp Damar Cer Derg 2013;21:659-668
- Wakefield TW, Henke PK. Erken ve geç venöz trombozda inflamasyonun rolü: Klinik anlamı var mı? Semin Vasc Surg 2005;18:118-129.
- Brill A, FuchsTA, Savchenko AS, et al.Neutrophil extracel- lular traps promote deep vein thrombosis in mice. J Thromb Haemost 2012;10:136–144.
- Bakirci EM, Topcu S, Kalkan K, et al. The Role of the Non- specific Inflammatory Markers in Determining the Anatom- ic Extent of Venous Thromboembolism. Clin Appl Thromb Hemost 2013;12:213-218.
- Ertas IE, Gungorduk K, Akman L, et al. Can preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios be used as predictive markers for lymph node metastasis in squamous cell carcinoma of the vulva? Eur J Obstet Gyne- col Reprod Biol 2013;171:138-142.
- Kaya H, Ertas F, Islamoglu Y, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014;20:50-54.
- Arhan M, Onal İK, Taş A, et al. The role of red cell distribu- tion width as a marker in infl ammatory bowel disease. Turk J Med Sci 2011;41:227-234.
- Cakal B, Akoz AG, Ustundag Y, et al. Red cell distribution width for assessment of activity of inflammatory bowel dis- ease. Dig Dis Sci 2009;54:842-847.
- Molnar T, Farkas K, Szepes Z, et al. RDW can be a useful additional marker in diagnosing Crohn’s disease and ulcer- ative colitis. Dig Dis Sci 2008;53:2828-2829.
- Clarke K, Sagunarthy R, Kansal S. RDW as an additional marker in inflammatory bowel disease/undifferentiated colitis. Dig Dis Sci 2008;53:2521-2523.
- Whittaker P, Chiu HH, Przyklenk K. Core 2. Epidemiology and Prevention of CV Disease: Physiology, Pharmacology and Lifestyle Abstract 16321: Increases in Red Cell Distri- bution Width as a Biomarker for Deep Vein Thrombosis. Circulation 2011;124:A16321.
Öz
Amaç: Derin ven trombozunun (DVT) seyrinde inflamasyonun rolü çeşitli çalışmalarda açıklanmıştır. Bu nedenle literatürde inflamatuar belirteçlerin bu hastalıkta rolü araştırılmıştır. Son dönemde, tam kan sayımı parametreleri (Hemogram) arasında inflamatuar belirteçlerin kısa ifadesi olarak nötrofil lenfosit oranı (NLR), platelet lenfosit oranı (PLR) gibi belirteçler sıkça kullanılmaya başlanmıştır. Bu çalışma da hemogram parametrelerinin DVT ile ilişkisi incelenmiştir. Yöntemler: Kliniğimize akut DVT tanısı ile başvuran 50 hasta (28 kadın, 22 erkek) çalışmaya dahil edildi. Hastaların tanıları klinik semptomlar ve Doppler ultrasonografi ile konuldu. Hastalardan ek inflamatuar cevap oluşturacak hastalığı olanlar değerlendirme dışı bırakıldı. Kontrol grubu olarak da 30 sağlıklı gönüllü seçildi. Bu hastaların retrospektif olarak rutin hemogram sonuçları değerlendirildi. Rutin hemogram parametreleri ve nonselektif inflamatuar belirteçler olan kırmızı hücre dağılım hacmi (RDW), beyaz küre (WBC), NLR, PLR nin ölçümleri istatistiksel olarak incelendi. Bulgular: Çalışmaya alınan hastaların yaş ortalaması 46.2±14.2 yıl olup %53\'ü kadın cinsiyette idi. Gruplar hematolojik parametreler açısından incelendiğinde DVT grubunda lenfosit (2.6±0.8 ve 2.1±0.7, p=0.003) ve platelet miktarları (322±144 ve 264±66, p=0.042) daha yüksek, hemoglobin (13.2±2.0 ve 14.6±1.5, p=0.002) ve hematokrit değerleri (38.7±5.1 ve 42.8±6.9, p
Anahtar Kelimeler
Tam kan sayımı derin ven trombozu platelet lenfosit oranı nötrofil lenfosit oranı
Kaynakça
- Heit JA. Venouse thromboembolism: disease burden, out- comes and risk factors. J Thromb Haemost 2005;3:1611– 1617.
- Nielsen JD. The incidence of pulmonary embolism during deep vein thrombosis. Phlebology 2013;28 Suppl 1:29-33.
- Karabinos I, Koulouris S, Kranidis A, Pastromas S, Exa- daktylos N, Kalofoutis A. Neutrophil count on admission predicts major in-hospital events in patients with a non-ST- segment elevation acute coronary syndrome. Clin Cardiol 2009;32:561-568.
- Reiter M, Bucek RA, Koca N, Dirisamer A, Minar E. Deep vein thrombosis and systemic inflammatory response: a pi- lot trial. Wien Klin Wochenschr 2003;115:111-114.
- Bucek RA, Reiter M, Quehenberger P, Minar E. C-reactive protein in the diagnosis of deep vein thrombosis. Br J Hae- matol. 2002;119:385-389.
- Culmer DL, Diaz JA, Hawley AE, et al. Circulating and vein wall P-selectin promote venous thrombogenesis during ag- ing in a rodent model. Thromb Res 2013;131:42-8.
- Roumen-Klappe EM, den Heijer M, van Uum SH, et al. In- flammatory response in the acute phase of deep vein throm- bosis. J Vasc Surg 2002;35:701-706.
- Wakefield TW, Strieter RW, Schaub R, et al. Venous throm- bosis prophylaxis by inflammatory inhibition without anti- coagulation therapy.Journal Of Vascular Surgery February 2000;31:309-324.
- Bucek RA, Reiter M, Quehenberger P, et al. C-reactive pro- tein in the diagnosis of deep vein thrombosis. Br J Haema- tol 2002;119:385-389.
- Bhat T, Teli S, Rijal J et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardio- vasc Ther 2013;11:55-9.
- Gary T, Pichler M, Belaj K, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in pe- ripheral arterial occlusive disease patients. PLoS One 2013;8:e67688
- White RH. The epidemiology of venous thromboembolism. Circulation 2003;107:I4-8.
- Lamping DL. Measuring health-related quality of life in venous disease: practical and scientific considerations. An- giology 1997;48:51-57.
- Çırak Y, Savcı S, Karahan Z, et al. Akut derin ven trom- bozu sonrası yaşam kalitesi: VEINES-QOL/Sym ölçeğinin kültürel adaptasyonu, güvenirliği ve geçerliği: Türkçe versiyon çalışması. Turk Gogus Kalp Damar Cer Derg 2013;21:659-668
- Wakefield TW, Henke PK. Erken ve geç venöz trombozda inflamasyonun rolü: Klinik anlamı var mı? Semin Vasc Surg 2005;18:118-129.
- Brill A, FuchsTA, Savchenko AS, et al.Neutrophil extracel- lular traps promote deep vein thrombosis in mice. J Thromb Haemost 2012;10:136–144.
- Bakirci EM, Topcu S, Kalkan K, et al. The Role of the Non- specific Inflammatory Markers in Determining the Anatom- ic Extent of Venous Thromboembolism. Clin Appl Thromb Hemost 2013;12:213-218.
- Ertas IE, Gungorduk K, Akman L, et al. Can preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios be used as predictive markers for lymph node metastasis in squamous cell carcinoma of the vulva? Eur J Obstet Gyne- col Reprod Biol 2013;171:138-142.
- Kaya H, Ertas F, Islamoglu Y, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014;20:50-54.
- Arhan M, Onal İK, Taş A, et al. The role of red cell distribu- tion width as a marker in infl ammatory bowel disease. Turk J Med Sci 2011;41:227-234.
- Cakal B, Akoz AG, Ustundag Y, et al. Red cell distribution width for assessment of activity of inflammatory bowel dis- ease. Dig Dis Sci 2009;54:842-847.
- Molnar T, Farkas K, Szepes Z, et al. RDW can be a useful additional marker in diagnosing Crohn’s disease and ulcer- ative colitis. Dig Dis Sci 2008;53:2828-2829.
- Clarke K, Sagunarthy R, Kansal S. RDW as an additional marker in inflammatory bowel disease/undifferentiated colitis. Dig Dis Sci 2008;53:2521-2523.
- Whittaker P, Chiu HH, Przyklenk K. Core 2. Epidemiology and Prevention of CV Disease: Physiology, Pharmacology and Lifestyle Abstract 16321: Increases in Red Cell Distri- bution Width as a Biomarker for Deep Vein Thrombosis. Circulation 2011;124:A16321.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2014 |
| Gönderilme Tarihi | 2 Mart 2015 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 41 Sayı: 1 |