Propolisin Bileşenlerinden Olan Kafeik Asit Fenil Esterin Antiinflamatuvar Etkileri

Yıl 2019, Cilt: 11 Sayı: 2, 43 - 47, 31.12.2019

Ozan Aldemir , Hikmet Memmedov

Öz

Kafeik asit fenil ester (CAPE), bol miktarda biyolojik aktivite barındıran bal arısı propolisinin önemli bir aktif bileşenidir. Kafeik asit fenil ester (CAPE), inflamasyon ve kanser de dahil olmak üzere çeşitli hastalıklardaki terapötik potansiyeli nedeniyle büyük ilgi görmektedir. Bu çalışmada Propolisin önemli bileşenlerinden olan CAPE’ın antiinflamatuvar etkileri incelenmiş ve CAPE'in, ksantin oksidaz, siklooksijenaz ve nükleer faktör ‑ κB (NF ‑ κB) aktivasyonu gibi bazı enzim aktivitelerinin inhibisyonunu içeren antiinflamatuar özelliklere sahip olduğu bildirilmiştir.

Anahtar Kelimeler

Kafeik asit fenil ester (CAPE), Propolis, İnflamasyon, Antiinflamatuvar

Antiinflammatory Effects Of Caffeic Acid Phenethyl Ester, One Of The Components Of Propolis

Öz

Caffeic acid phenethyl ester (CAPE) is an important active ingredient of honey bee propolis, which contains abundant biological activity. Caffeic acid phenethyl ester (CAPE) has recently received great attention due to its therapeutic potential in a variety of diseases including inflammation and cancer. In this study, antiinflammatory effects of caffeic acid phenyl ester, one of the important components of propolis, were investigated and it was reported that CAPE has antiinflammatory properties including inhibition of some enzyme activities such as xanthine oxidase, cyclooxygenase and nuclear factor - κB (NF - κB) activation.

Anahtar Kelimeler

Caffeic acid phenethyl ester (CAPE), Propolis, Inflammation, Antiinflammatory

Kaynakça

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