Propolisin Bileşenlerinden Olan Kafeik Asit Fenil Esterin Antiinflamatuvar Etkileri

Yıl 2019, Cilt: 11 Sayı: 2, 43 - 47, 31.12.2019

Ozan Aldemir Hikmet Memmedov

Öz

Kafeik asit fenil ester (CAPE), bol miktarda biyolojik aktivite barındıran bal arısı propolisinin önemli bir aktif bileşenidir. Kafeik asit fenil ester (CAPE), inflamasyon ve kanser de dahil olmak üzere çeşitli hastalıklardaki terapötik potansiyeli nedeniyle büyük ilgi görmektedir. Bu çalışmada Propolisin önemli bileşenlerinden olan CAPE’ın antiinflamatuvar etkileri incelenmiş ve CAPE'in, ksantin oksidaz, siklooksijenaz ve nükleer faktör ‑ κB (NF ‑ κB) aktivasyonu gibi bazı enzim aktivitelerinin inhibisyonunu içeren antiinflamatuar özelliklere sahip olduğu bildirilmiştir.

Anahtar Kelimeler

Kafeik asit fenil ester (CAPE), Propolis, İnflamasyon, Antiinflamatuvar

Antiinflammatory Effects Of Caffeic Acid Phenethyl Ester, One Of The Components Of Propolis

Öz

Caffeic acid phenethyl ester (CAPE) is an important active ingredient of honey bee propolis, which contains abundant biological activity. Caffeic acid phenethyl ester (CAPE) has recently received great attention due to its therapeutic potential in a variety of diseases including inflammation and cancer. In this study, antiinflammatory effects of caffeic acid phenyl ester, one of the important components of propolis, were investigated and it was reported that CAPE has antiinflammatory properties including inhibition of some enzyme activities such as xanthine oxidase, cyclooxygenase and nuclear factor - κB (NF - κB) activation.

Anahtar Kelimeler

Caffeic acid phenethyl ester (CAPE), Propolis, Inflammation, Antiinflammatory

Kaynakça

• Abdel-Latif MM, Windle HJ, Homasany BS, et al. 2005, Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells. Br J Pharmacol;146:1139e47.
• Anjaly Km and Tiku Ashu B. 2018, Radio-Modulatory Potential of Caffeic Acid Phenethyl Ester: A Therapeutic Perspective, Anti-Cancer Agents in Medicinal Chemistry, 18, 468-475.
• Armutçu, F., Akyol, S., Ustünsoy S. and Turan, F. F., 2015, Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects, Experimental and Therapeutic Medicine 9: 1582-1588.
• Bezerra, R. M., Veiga, L. F., Caetano, A. C., Rosalen, P. L., Amaral, M. E., et al. 2012, Caffeic acid phenethyl ester reduces the activation of the nuclear factor kappaB pathway by high-fat diet-induced obesity in mice. Metabolism 61, 1606–1614.
• Borrelli F, Maffia P, Pinto L, Ianaro A, Russo A, Capasso F, Ialenti, A., 2002, Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia 73: S53-S63.
• Boudreau, L. H., Maillet, J., LeBlanc, L. M., Jean-Francois, J., Touaibia, M., et al., 2012, Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes. PLoS One 7, e31833.
• Carreno, A.L, Alday,E., Quintero, J. Perez, L., Valencia, D., Zepeda, R.R., Ortega,J.V, Hernandez, J., Velazquez C., 2017, Protective effect of Caffeic Acid Phenethyl Ester (CAPE) against oxidative stress, Journal of Functional Foods 29, 178–184.
• Chen L. Deng H. Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X and Zhao, L., 2018, Inflammatory responses and inflammation-associated diseases in organs, Oncotarget, Vol. 9, (No. 6), pp: 7204-7218
• Cho M. S., Park, W.S., Jung,W.K, Qian,Z.J., Lee,D.S., et al., 2014, Caffeic acid phenethyl ester promotes antiinflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells, Pharm Biol.; 52(7): 926–932.
• Celik, S. and Erdogan, S. 2008, Caffeic acid phenethyl ester (CAPE) protects brain against oxidative stress and inflammation induced by diabetes in rats. Mol. Cell. Biochem. 312, 39–46.
• Ferrero-M.L., Nielsen O.H., Andersen P.S. and Girardin S.E., 2007 : Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation, Clin Exp Immunol;147:227-35.
• Goldman, L., Schafer, A.I., 2012,“Mechanisms of inflammation and tissue repair”Cecil Medicine: Expert Consult Premium Edition 24th Saunders (Elsevier);1604-7.
• Ilhan A, Akyol O, Gurel A, Armutcu F, Iraz M and Oztas E, 2004, Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis‑induced oxidative stress in rats. Free Radic Biol Med 37: 386‑394.
• Khan M, Elango C, Ansari MA, Singh I and Singh AK. 2007, Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem 102: 365‑377.
• Lu, H., Ouyang, W. and Huang, C., 2006, Inflammation, a Key Event in Cancer Development, Mol Cancer Res ;4(4).
• Marquez, N., Sancho, R., Macho, A., Calzado, M. A., Fiebich, B. L., et al. 2004, Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. J. Pharmacol. Exp. Ther. 308, 993–1001.
• Murtaza, G., Karim, S., Akram, M.R., Khan, S. A., Azhar, S., Mumtaz, A. and Asad, M.H.H., 2014, Review Article Caffeic Acid Phenethyl Ester and Therapeutic Potentials, BioMed Research International Volume, 9 p.
• Raso GM, Meli R, Di Carlo G, et al. 2001, Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci;68:921e31.
• Sforcin, J.M. and Bankova, V., 2011, “Propolis: Is there a potential for the development of new drugs?”, Journal of Ethnopharmacology 133, 253-260.
• Son, S., Lobkowsky, E.B. and Lewis, B.A., 2001, “Caffeic acid phenethyl ester (CAPE): synthesis and X-ray crystallographic analysis”, Chemical and Pharmaceutical Bulletin 49, 236-238.
• Song, J. J., Lim, H. W., Kim, K., Kim, K. M., Cho, S., et al. 2012, Effect of caffeic acid phenethyl ester (CAPE) on H(2)O(2) induced oxidative and inflammatory responses in human middle ear epithelial cells. Int. J. Pediatr. Otorhinolaryngol. 76, 675–679.
• Toyoda T, Tsukamoto T, Takasu S, Shi L, Hirano N, Ban H, Kumagai T and Tatematsu M, 2009, Anti‑inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor‑kappaB inhibitor, on Helicobacter pylori‑induced gastritis in Mongolian gerbils. Int J Cancer 125: 1786‑1795.