Gebelik Hipertrofik Skar ve Keloid İçin Ortak Bir Tetikleyici Olabilir mi? Vaka Sunumu

Öz

Hipertrofik skar ve keloid, anormal yara iyileşmesinin sonucu olarak ortaya çıkan başlıca patolojilerdir. Tedavi seçeneklerinin kısıtlılığı ve sonuçlarının estetik açıdan yetersizliği bu patolojilerin klinik önemini artırmaktadır. Bu nedenle cerrahi girişimler öncesinde, yara iyileşmesini etkileyecek etiyolojik faktörler detaylı olarak sorgulanmalıdır. Bu vaka sunumuyla, gebeliğin bu süreçteki olumsuz etkilerine ve bu sonuçlar için alınması gereken tedbirlere dikkat çekmeyi amaçladık.

Anahtar Kelimeler

• Hipertrofik skar,keloid,gebelik

Could Pregnancy be a Common Trigger Factor for Hypertrophic Scar And Keloid? A Case Report

Abstract

Hypertrophic scar and keloid are the main pathologic results after an abnormal wound healing process. Limited treatment options and unsatisfactory outcomes make the pathologies in need of more clinical interest. For this reason etiological factors must be detailly questioned before the surgical procedures. With this case report, we aimed to highlight the role of pregnancy and the precautions for unexpected outcomes in this process.

Keywords

• Hypertrophic scar,keloid,pregnancy

Kaynakça

1. 1. Huang, C., et al., Keloids and hypertrophic scars: update and future directions. Plast Reconstr Surg Glob Open, 2013; 1:e25.
2. 2. Nakashima, M., et al., A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. Nat Genet, 2010; 42: 768-71.
3. 3. Miller, M.C. and J. Nanchahal, Advances in the modulation of cutaneous wound healing and scarring. BioDrugs, 2005; 19: 363-81.
4. 4. Ogawa, R., S. Akaishi, and M. Izumi, Histologic analysis of keloids and hypertrophic scars. Ann Plast Surg, 2009; 62: 104-5.
5. 5. Ogawa, R., S. Akaishi, and H. Hyakusoku, Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg, 2009; 62: 660-4.
6. 6. Ogawa, R., et al., Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy. J Nippon Med Sch, 2016; 83: 46-53.
7. 7. Akaishi, S., et al., Nd:YAG Laser Treatment of Keloids and Hypertrophic Scars. Eplasty, 2012; 12: e1.
8. 8. Moustafa, M.F., M.A. Abdel-Fattah, and D.C. Abdel-Fattah, Presumptive evidence of the effect of pregnancy estrogens on keloid growth. Case report. Plast Reconstr Surg, 1975; 56: 450-3.

9. 9. Park, T.H. and C.H. Chang, Keloid recurrence in pregnancy. Aesthetic Plast Surg, 2012; 36:1271-2.
10. 10. Ziegler, U.E., [International clinical recommendations on scar management]. Zentralbl Chir, 2004; 129:296-306.
11. 11. Fong, E.P. and B.H. Bay, Keloids - the sebum hypothesis revisited. Med Hypotheses, 2002; 58: 264-9.
12. 12. Arima, J., et al., Hypertension: a systemic key to understanding local keloid severity. Wound Repair Regen, 2015;23: 213-21.
13. 13. Huang, C. and R. Ogawa, The link between hypertension and pathological scarring: does hypertension cause or promote keloid and hypertrophic scar pathogenesis? Wound Repair Regen, 2014;22: 462-6.
14. 14. Branski, L.K., H.O. Rennekampff, and P.M. Vogt, [Keloid and hypertrophic scar treatment modalities. An update]. Chirurg, 2012; 83: 831-4, quiz 845-6.
15. 15. Huang, D., K.H. Shen, and H.G. Wang, Pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue. Chin Med J (Engl), 2013; 1263321-4.
16. 16. Rabello, F.B., C.D. Souza, and J.A. Farina Junior, Update on hypertrophic scar treatment. Clinics (Sao Paulo), 2014; 69:565-73.
17. 17. Rha, E.Y., et al., Topical Application of a Silicone Gel Sheet with Verapamil Microparticles in a Rabbit Model of Hypertrophic Scar. Plast Reconstr Surg, 2016;137: 144-51