Hormone Levels in Male Cases With Behcet's Disease

Year 2023, , 200 - 206, 29.12.2023

Tuna Sezer , Hilmi Cevdet Altınyazar , Rafet Koca , Nilgün Solak Tekin , Saniye Çınar

https://doi.org/10.47493/abantmedj.1349095

Abstract

Objective: Behcet's disease (BD) is a chronic relapsing systemic inflammatory disease with no clear etiopathogenesis. Because the disease usually starts during the sexually active period and shows a more severe course in males, we aimed to evaluate the hypothalamo-hypophyseal-gonadal axis in male patients.
Materials and Methods: Our study included 25 male patients with Behcet's disease and 22 healthy males. In accordance with our purpose, patients and healthy participants were stimulated with gonadotropin releasing hormone (GnRH) followed by examination of the blood for sex hormone binding globulin (SHBG), cortisol, estradiol, free and total testosterone, androstenedione, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), and follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels. The results were compared between the groups.
Results: Estradiol levels were significantly higher in the patient group (36.80±14.70 pg/ml) compared to the control group (29.30±9.15 pg/ml) (p=0.045). Conversely, DHEA levels were significantly lower in patient group (13.74±7.96 ng/ml) than in control group (18.36±7.12 ng/ml) (p=0.043). Levels of the other hormones did not show any significant difference between the groups.
Conclusion: In order to better evaluate the roles of hormones and the hypothalamo-hypophyseal-gonadal axis in relation to the etiopathogenesis of BD, there is a need for larger scale studies, which also take into account disease activity.

Keywords

Behcet, Male, Hormone

Erkek Behçet Hastalarında Hormon Düzeyleri

Abstract

Amaç: Behçet hastalığı (BH), etiyopatogenezi tam olarak bilinmeyen kronik, relapslarla seyreden sistemik inflamatuvar bir hastalıktır. Hastalığın daha çok cinsel aktif dönemde başlaması ve erkeklerde daha şiddetli klinik seyir göstermesi nedeniyle çalışmamızda erkek hastalarda hipotalamo-hipofizer-gonadal aksı değerlendirmeyi uygun gördük.
Gereç ve Yöntemler: Çalışmamıza 25 erkek Behçet hastası ve 22 sağlıklı erkek dahil edildi. Bu amaçla hastalarda ve sağlıklı bireylerde prolaktin, seks hormonu bağlayan globulin (SHBG), kortizol, östradiol, serbest ve total testosteron, androstenedion, dehidroepiandrosteron (DHEA), dehidroepiandrosteron sülfat (DHEAS) ve gonadotropin salgılatıcı hormon (GnRH) testine folikül stimüle eden hormon (FSH) ve luteinize hormon (LH) cevaplarına bakıldı ve sonuçlar karşılaştırıldı.
Bulgular: Her iki grup arasında hormon düzeyleri incelendiğinde, hasta grubunda östradiol düzeyleri (36,80±14,70 pg/ml) kontrol grubuna (29,30±9,15 pg/ml) göre anlamlı olarak (p=0,045) daha yüksek bulundu. Hasta grubunda DHEA düzeyleri(13,74±7,96 ng/ml) kontrol grubuna (18,36±7,12 ng/ml) göre anlamlı olarak (p=0,043) daha düşük tespit edilmiştir. Diğer hormonlar açısından gruplar arasında anlamlı fark yoktu.
Sonuç: BH’nin etyopatogenezi ile ilişkili olarak hormonların ve hipotalomo-hipofizer-gonadal aksın olası rolünü daha iyi değerlendirmek amacıyla özellikle hastalık aktivitesini de dikkate alan daha geniş serili çalışmalara ihtiyaç vardır.

Keywords

Behçet, Erkek, Hormon

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