Öz
Neoplasms derived from leptomeningeal melanocytes are uncommon lesions that present in diffuse or localized form. Localized lesions present sporadically as meningeal masses and range from well differantiated melanocytomas to malignant, potentially disseminating melanomas. Most tumors commomly occur in the posterior fossa,in Meckel's cave and within the toracic spinal canal. We report one cases of spinal melanocytoma 66 year-old-female with immunohistochemical and ultrastructural studies.Tumor invaded the spinal cord and MIB-1 staining was %2. Tumor was totaly excised. So we tought that this tumor can recur. After 3 year following no recurrence was seen.
Kaynakça
- Gebarski SS, Blaivas MA. Imaging of normal leptome- ningeal melanin. AJNR Am J Neuroradiol. 1996;17:55- 60.
- Goldgeier MH, Klein LE, Klein-Angerer S, Moellmann G, Nordlund JJ. The distribution of melanocytes in the leptomeninges of the human brain. J Invest Dermatol. 1984;82:235-238.
- Brat DJ, Giannini C, Scheithauer BW, Burger PC. Pri- mary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol. 1999;23:745-754.
- Bydon A, Gutierrez JA, Mahmood A. Meningeal mela- nocytoma: an aggressive course for a benign tumor. J Neurooncol. 2003;64:259-263.
- Ferracini R, Gardini G, Brisigotti M, Lanzanova G, Manetto V, Lorenzini P. Metastasizing meningeal me- lanocytoma. Tumori. 1980;66:405-408.
- Brat DJ, Giannini C, Scheithauer BW, Burger PC. Pri- mary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol. 1999;23:745-754.
- Lida M, Lena JF, Suarez MA, Malik S, Weidenheim KM, LaSala P, Hirano A. Two cases of spinal meningeal me- lanocytoma. Brain Tumor Pathol. 2002;19;41-45.
- Uematsu Y, Yukawa S, Yokote H, Itakura T, Hayashi S, Komai N. Meningeal melanocytoma: magnetic reso- nance imaging characteristics and pathological fea- tures. Case report. J Neurosurg. 1992;76:705-709.
Öz
Leptomeningeal melanositlerden köken alan neoplaziler diffüz ya da lokalize formları bulunan nadir görülen tümörlerdir. Lokalize lezyonlar sporadik olarak iyi diferansiye melanositomlardan potansiyel olarak yayılan melanomlara kadar değişen bir spektrum gösteren meningeal kitleler şeklinde ortaya çıkar. Pek çok tümör sıklıkla posterior fossada, Meckel boşluğunda ve torasik boşlukta yerleşir. Biz bu çalışmada 66 yaşında kadın hastada immünohistokimyasal ve ultrastrüktürel çalışmalar eşliğinde spinal melanositom olgusu sunduk. Tümör spinal kordu infiltre etmiş olup, MIB-1 indeksi %2 oranındaydı. Tümör total olarak eksize edildi. Bu tümörün tekrarlayabileceğini düşündüğümüz halde takip eden 3 yıl içerisinde tümör rekürrensi izlenmedi.
Kaynakça
- Gebarski SS, Blaivas MA. Imaging of normal leptome- ningeal melanin. AJNR Am J Neuroradiol. 1996;17:55- 60.
- Goldgeier MH, Klein LE, Klein-Angerer S, Moellmann G, Nordlund JJ. The distribution of melanocytes in the leptomeninges of the human brain. J Invest Dermatol. 1984;82:235-238.
- Brat DJ, Giannini C, Scheithauer BW, Burger PC. Pri- mary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol. 1999;23:745-754.
- Bydon A, Gutierrez JA, Mahmood A. Meningeal mela- nocytoma: an aggressive course for a benign tumor. J Neurooncol. 2003;64:259-263.
- Ferracini R, Gardini G, Brisigotti M, Lanzanova G, Manetto V, Lorenzini P. Metastasizing meningeal me- lanocytoma. Tumori. 1980;66:405-408.
- Brat DJ, Giannini C, Scheithauer BW, Burger PC. Pri- mary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol. 1999;23:745-754.
- Lida M, Lena JF, Suarez MA, Malik S, Weidenheim KM, LaSala P, Hirano A. Two cases of spinal meningeal me- lanocytoma. Brain Tumor Pathol. 2002;19;41-45.
- Uematsu Y, Yukawa S, Yokote H, Itakura T, Hayashi S, Komai N. Meningeal melanocytoma: magnetic reso- nance imaging characteristics and pathological fea- tures. Case report. J Neurosurg. 1992;76:705-709.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Editöre Mektup |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Eylül 2012 |
| Yayımlandığı Sayı | Yıl 2012 Cilt: 1 Sayı: 3 |