Management of Wound Site Infections

Year 2025, Volume: 14 Issue: 2, 112 - 129, 29.08.2025

Huseyn Babayev , Muhammet Kurtoğlu

https://doi.org/10.47493/abantmedj.1699572

Abstract

Wound infections are a significant problem in clinical practice, affecting millions of people worldwide. These infections contribute to prolonged hospital stays, increased healthcare costs, and increased morbidity and mortality. This review provides a comprehensive review of various wound types and their associated changing etiological agents. Special attention is paid to antimicrobial resistance (AMR), a growing global public health problem that complicates wound management. We discuss how genetic factors and specific virulence mechanisms enable pathogens to resist standard antimicrobial treatments, how these challenges lead to biofilm formation, and how chronic wounds are worsened by different microorganisms. Strategies for achieving accurate and timely diagnosis are discussed, including new diagnostic approaches that could revolutionize clinical practice. Antimicrobial treatment methods and other treatment methods (such as debridement, negative pressure, hyperbaric oxygen) are reviewed in detail. In addition, the importance of infection control practices, antimicrobial stewardship, patient education, and infection prevention and control methods are emphasized. Future perspectives focus on identifying new antimicrobials, alternative therapies, improved diagnostic tools, better understanding of AMR mechanisms, and emphasizing the urgent need for integrative and personalized approaches to wound management. By synthesizing the current state of knowledge and identifying gaps for further research, this review highlights the importance of collaborative, multidisciplinary efforts to alleviate the burden of wound infections and counter the rise of antimicrobial resistance.

Keywords

Wound infections , antimicrobial resistance , biofilm , chronic wounds , multidrug-resistant pathogens

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