Biyojenik Örneklerde ve Uyuşturucu Ele Geçirmelerde Yeni Psikoaktif Maddelerin Anında Tespiti İçin Analitik Araçlar

Öz

Gerekli referans standartlara sahip olmadan yeni ilaçların ve metabolitlerin tanımlanması ve miktarının belirlenmesi bir zorluktur. Referans standartları ticari, hükümet ve uluslararası kaynaklardan temin edilebilir olsa da, teslim süreleri birkaç haftadan birkaç aya kadar uzun olabilir. Bu makalede, uluslararası düzeyde NPS ile mücadelede muhtemelen yardımcı olabilecek bazı analitik araçlar tanımlanmıştır.

Anahtar Kelimeler

• Yeni Psikoaktif Maddeler
• Sentetik Oioidler
• Sentetik Uyarıcılar
• Yüksek Çözünürlüklü Kütle Sptekrometrisi
• Kemilüminesans Azot Tespiti

Analytical Tools for Instant Determination of New Psychoactive Substances in Biological Samples and Drug Seizures

Öz

Identification and quantification of new drugs and metabolites without possessing the required reference standards is a challenge. Although reference standards may be available from commercial, governmental and international sources, their delivery time is lengthy, ranging from several weeks to several months. In this paper, some analytical tools are described that are probably helpful in the combat against NPS on an international level.

Anahtar Kelimeler

• New Psychoactive Substances
• Synthetic Opioids
• Synthetic Stimulants
• High-Resolution Mass Spectrometry
• Chemiluminescence Nitrogen Detection

Kaynakça

1. Kriikku, P., Pelander, A., Rasanen, I. ve Ojanperä, I. (2019). Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data. Forensic Sci Int, C. 300, ss. 85-88.
2. Mesihää, S., Rasanen, I., Pelander, A. ve Ojanperä, I. (2019). Quantitative estimation of 38 illicit psychostimulants in blood by GC-APCI-QTOFMS with nitrogen chemiluminescence etection based on three external calibrators. J Anal Toxicol, C. 44, S. 2, ss. 163-172.
3. Rasanen, I., Kyber, M., Szilvay, I., Rintatalo, J. ve Ojanperä, I. (2019) Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection. Forensic Sci Int, C. 305.
4. Sundström, M., Pelander, A. ve Ojanperä, I. (2017). Comparison of post-targeted and pretargeted urine drug screening by UHPLC-HR-QTOFMS. J Anal Toxicol, C. 41, S. 7, ss. 623-630.
5. United Nations. (2019). World Drug Report. https://wdr.unodc.org/wdr2019/prelaunch/ WDR19_Booklet_1_EXECUTIVE_SUMMARY.pdf E.T. 9 Kasım 2019.