Evaluation of atherogenic index of plasma levels at hypertensive patients

Yıl 2019, , 72 - 75, 01.08.2019

Özge Turgay Yıldırım , Ercan Akşit , Fatih Aydın , Ayşe Hüseyinoğlu Aydın

https://doi.org/10.25000/acem.563986

Cited By: 1

Öz

Aim: Hypertension is a major risk factor for
cardiovascular system. Recent studies showed that atherogenic index of plasma
(AIP) has a strong association with cardiovascular morbidity, all-cause
mortality, atherosclerosis and severity of coronary artery disease. It also has
a relationship with endothelial damage in hypertensive patients. With this
study we aim to investigate the association between AIP and hypertension.

Methods: A total of 213 patients were enrolled
for the study. Patients with previous hypertension, nephrotic syndrome,
diabetes mellitus, hypotiroidism diagnosis, patients under statin treatment and
patients under 18 years of age were excluded. Diagnosis of hypertension and
blood pressure (BP) results were obtained with 24-hour ambulatory blood
pressure monitoring (ABPM). AIP was defined as the logarithmic transformation
of the triglyceride to high-density lipoprotein-cholesterol ratio.

Results: Mean age of the population was 49.2
± 14.6 years and 41.8% (n=89) was male. According to 24-hour ABPM results, AIP
was positively correlated with day-time systolic blood pressure (SBP) (r=0.244,
p<0.001), day-time diastolic blood pressure (DBP) (r=0.276, p<0.001),
night-time SBP (r=0.259, p<0.001), night-time DBP (r=0.299, p<0.001),
average SBP (r=0.213, p=0.002) and average DBP (r=0.296, p<0.001). AIP was
also increased in hypertensive patients compared to normotensive subjects
(p=0.001).

Conclusion:
Results of our study showed that AIP was positively correlated with blood
pressure and statistically higher in patients with hypertension.

Anahtar Kelimeler

Atherogenic index of plasma, hypertension, blood pressure, ambulatory blood pressure monitoring

Hipertansif hastalarda plazma aterojenik indeks düzeylerinin incelenmesi

Öz

Amaç: Hipertansiyon, kardiyovasküler sistem
için önemli risk faktörlerinden biridir. Son dönemde yapılan araştırmalar,
plazma aterojenik indeksinin (PAİ) kardiyovasküler morbidite, tüm nedenlere
bağlı ölüm, ateroskleroz ve koroner arter hastalığının ciddiyeti ile güçlü bir
ilişkisi olduğu gösterilmiştir. Ayrıca hipertansif hastalarda endotel hasarı
ile ilişkisi vardır. Biz bu çalışma ile PAİ ile hipertansiyon arasındaki
ilişkiyi araştırmayı amaçladık.

Yöntemler: Çalışmaya toplam 213 hasta alındı.
Daha önce hipertansiyon, nefrotik sendrom, diyabetes mellitus, hipotiroidizm
tanısı olan, statin tedavisi alan ve 18 yaşın altındaki hastalar çalışmadan
dışlandı. 24 saatlik ambulatuvar kan basıncı ölçümü ile hipertansiyon tanısı ve
kan basıncı (KB) sonuçları alındı. PAİ, trigliseritin yüksek yoğunluklu
lipoprotein kolesterol oranının logaritmik dönüşümü olarak tanımlandı.

Bulgular: Çalışmaya katılan hastaların yaş
ortalaması 49,2 ± 14,6 yıl idi ve % 41,8'ü (n = 89) erkekti. 24 saatlik
ambulatuar kan basıncı ölçümü sonuçlarına göre, PAİ, gündüz sistolik kan
basıncı (SKB) (r=0,244, p<0,001), gündüz diyastolik kan basıncı (DKB)
(r=0,276, p<0,001), gece SBP (r=0,259, p<0,001), gece DKB (r=0,299,
p<0,001), ortalama SKB (r=0.213, p=0,002) ve ortalama DKB (r=0,296,
p<0,001) ile pozitif olarak korele idi. Hipertansif hastalarda PAİ
normotansif hastalara göre istatistiksel olarak anlamlı düzeyde yüksekti
(p=0,001).

Sonuç:
Çalışmamızın sonucunda PAİ'nin kan basıncıyla pozitif olarak korele olduğu ve
PAİ değerlerinin hipertansif hastalarda istatistiksel açıdan anlamlı şekilde
yüksek olduğunu saptamıştır.

Anahtar Kelimeler

Plazma aterojenik indeksi, hipertansiyon, kan basıncı, 24 saatlik ambulatuar kan basıncı ölçümü

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