Is Aspartate Aminotransferase to Alanine Aminotransferase (De Ritis Ratio) Helpful in Predicting Breast Cancer?

Abstract

Aim: De Ritis ratio (aspartate transaminase/alanine transaminase) may be a useful prognostic biomarker for certain malignant tumors. However, the predictive value of the De Ritis ratio before treatment in preoperative staging in patients with breast cancer is unknown. This study aimed to evaluate the De Ritis ratio in benign and malignant breast diseases and investigate the predictive value of it for breast cancer. Methods: Retrospective analysis was made of the clinicopathological data of 301 patients with benign breast disease and breast cancer treated between April 2017 and April 2020 in a single center. 64 Patients were excluded from the study due to chronic illness or incomplete data. The relationship between the De Ritis ratio and clinicopathological findings before treatment was evaluated in patients. The Mann Whitney U test and Kruskal Wallis test were used in the comparisons between groups. Results: Of the total 237 patients, the number of patients with benign breast disease was 96 and the number of the patients with breast cancer was 141. No statistically significant results were determined between the benign breast disease and breast cancer groups, in respect of pre-treatment evaluation of the De Ritis ratio and as a predictive factor for preoperative staging in molecular subtyping, tumor diameter, lymph node metastasis, and Ki 67 index. Conclusion: It was concluded that the De Ritis ratio examined before treatment was not an independent predictive factor in breast cancer diagnosis and staging.

Keywords

• De ritis ratio
• aspartate transaminase
• alanine transaminase
• breast cancer
• predictive factor

Aspartat Aminotransferaz/Alanin Aminotransferaz (De Ritis Oranı) Oranı Meme Kanserini Tahmin Etmede Yardımcı Olur mu?

Öz

Amaç: De Ritis oranı (aspartat transaminaz / alanin transaminaz) belirli malign tümörler için yararlı bir prognostik biyobelirteç olabilir. Bununla birlikte, meme kanseri olan hastalarda tedavi öncesi incelenen De Ritis oranının preop evrelemede prediktif değeri büyük ölçüde bilinmemektedir. Bu çalışmanın amacı, benign ve malign meme hastalıklarında De Ritis oranını değerlendirmek ve bunun meme kanseri için prediktif değerini araştırmaktır. Yöntemler: Nisan 2017- nisan 2020 yılları arasında benign meme hastalığı ve meme kanserli 301 hastanın klinikopatolojik verileri tek bir merkezde retrospektif olarak analiz edildi. Kronik hastalığı olan veya veri eksiği olan 64 hasta çalışmadan çıkarıldı. De Ritis oranının tedavi öncesi değeri ile, hastaların klinikopatolojik bulguları arasındaki ilişki değerlendirildi. Gruplar arası karşılaştırmalarda Mann Whitney U testi ve Kruskal Wallis testi kullanıldı. Bulgular: 237 hastada, benign meme hastalığı olan 96, meme kanseri olan hasta sayısı ise 141 idi. De ritis oranın tedavi öncesi değeri ile, benign meme hastalığı ve meme kanseri arasında, ayrıca meme kanserinde prognostik faktör olan moleküler subtiplendirme, tümör çapı, lenf nodu metastazı ve Ki 67 indeksinde preoperatif evrelemede prediktif faktör olarak istatisksel anlamlı sonuçlara ulaşılamadı. Sonuç: Tedavi öncesi incelenen De ritis oranın meme kanseri evrelemesinde bağımsız prediktif faktör olmadığı sonucuna ulaşıldı.

Anahtar Kelimeler

• De Ritis oranı
• aspartat transaminaz
• alanin transaminaz
• meme kanseri
• prediktif faktör

Kaynakça

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