Laparoskopik sleeve gastrektomi sonrası probiyotik takviyesinin konstipasyon ve gastrointestinal yaşam kalitesi üzerine etkisi

Öz

Amaç: Bu çalışmada, Laparoskopik Sleeve Gastrektomi (LSG) sonrası probiyotik takviyesinin, konstipasyon ve gastrointestinal yaşam kalitesi üzerine erken dönem etkisinin araştırılması amaçlanmıştır. Yöntemler: Bu çalışma, prospektif, randomize klinik çalışmadır. Katılımcıları Bariatriklab Obezite ve Metabolik Cerrahi Merkezi’ne LSG için başvuran bireyler oluşturmaktadır. Tüm hastalar, basit randomizasyon kullanılarak randomize örnekleme ile probiyotik ve kontrol olmak üzere 2 gruba ayrıldı. Probiyotik grubu, LSG sonrası 6 hafta boyunca probiyotik takviyesi olarak Bifidobacterium animalis lactis BB-12 suşunu kullandı. Hastaların, LSG öncesi ve sonrası 2.hafta, 4.hafta, 6.haftanın sonunda Gastrointestinal Semptom Derecelendirme Ölçeği (GSRS), Konstipasyon Ciddiyet Ölçeği (CSI), Konstipasyon Yaşam Kalitesi Ölçeği (PAC-QOL), Bristol Dışkı Formu Skalası (BSFS), Gastrointestinal Yaşam Kalitesi İndeksi (GIQLI) kaydedildi. Bulgular: Probiyotik grubun yaş ortalaması 37,00±8,92 (18 kadın, 12 erkek), kontrol grubunun yaş ortalaması 41,03±11,29 (23 kadın, 7 erkek) idi. CSI (16,50 ± 14,76 ile 31,37 ± 15,34), PAC-QOL (58,53 ± 12,59 ile 72,30 ± 19,70), GSRS (26,83 ± 9,14 ile 37,93 ± 16,59) ve toplam puan ortalaması kontrol grubuna göre daha düşük, GIQLI toplam puan ortalaması (147,50 ± 11,79 ile 136,87 ± 18,98) daha yüksek bulundu (p <0,05). Sonuç: LSG sonrası erken dönemde probiyotik takviyesi alan grupta, kontrol grubuna kıyasla konstipasyon ve gastrointestinal yaşam kalitesinde iyileşmeler gözlenmiştir.

Anahtar Kelimeler

• Bariatrik cerrahi
• gastrointestinal yaşam kalitesi
• konstipasyon
• sleeve gastrektomi
• probiyotik

Effect of probiotic supplementation after laparoscopic sleeve gastrectomy on constipation and gastrointestinal quality of life

Abstract

Aim: In this study, we aimed to investigate the early effect of probiotic supplementation after Laparoscopic Sleeve Gastrectomy (LSG) on constipation and gastrointestinal quality of life compared to control group. Methods: This study was a prospective, randomized clinical trial. Participants were recruited to Bariatriklab Obesity and Metabolic Surgery Center for LSG. All patients were divided into 2 groups as probiotic and control by using simple randomization. The probiotic group consumed Bifidobacterium animalis lactis BB-12 strain as a probiotic supplement during 6 weeks after LSG. Gastrointestinal Symptom Rating Scale (GSRS), Constipation Severity Instrument (CSI), Patient Assessment of Constipation Quality of Life Scale (PAC-QOL), Bristol Stool Form Scale (BSFS), Gastrointestinal Quality of Life Index (GIQLI) of the patients were recorded before LSG and at the 2nd, 4th, 6th weeks after LSG. Results: The probiotic group had an average age of 37.00±8.92 years (18 female, 12 male), the control group had an average age of 41.03±11.29 years (23 female, 7 male). CSI (16.50 ± 14.76 vs. 31.37 ± 15.34), PAC-QOL (58.53 ± 12.59 vs 72.30 ± 19.70), GSRS (26.83 ± 9.14 vs. 37.93 ± 16.59) and total score mean were lower compared to the control group, GIQLI total score average (147.50 ± 11.79 vs 136.87 ± 18.98) was found higher (p <0.05) in probiotic group. Conclusion: Probiotic supplementation improved the constipation and gastrointestinal quality of life in the early post-LSG period in the probiotic group compared to the control group.

Keywords

• Bariatric surgery
• gastrointestinal quality of life
• constipation
• sleeve gastrectomy
• probiotics

Kaynakça

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