Aksiller kitle ile ortaya çıkan granüler hücreli tümör: Bir olgu sunumu

Yıl 2020, Cilt: 5 Sayı: 1, 32 - 34, 20.03.2020

Bülent Çitgez Çitgez Banu Yiğit , Sıtkı Gürkan Yetkin Mehmet Mihmanlı

https://doi.org/10.25000/acem.645475

Öz

Granüler hücreli tumor (GHT), hemen hemen vücudun her bölgesinde ortaya çıkabilen bir tümördür. Vakaların yaklaşık % 5 ila 15'i memede görülür ve aksillada nispeten nadir ortaya çıkarlar. Granüler hücreli tümörlerin % 1-2'si maligndir. Meme GHT'lerinin klinik semptomları ve görüntüleme incelemeleri spesifik değildir ve malign tümörlerle kolayca karışabilir. Çoğu iyi huyludur ve bildirilen malign vakalar nadirdir. Aksiller bölgede yaklaşık 2 yıldır palpabl kitlesi olan ve granüler hücreli tumor tanısı alan 59 yaşında bir erkek hastayı sunuyoruz. Palpabl kitlesi yaklaşık 15 mm çapındaydı ve klinik olarak malignite şüphesi vardı. Kitlenin kalın iğne biyopsisi granüler hücreli tümör özellikleri gösterdi ve cerrahi eksizyon yapıldı. Tümörün erken tanısı ve tam rezeksiyonu en iyi tedavi yöntemi olmaya devam etmektedir.

Anahtar Kelimeler

Granüler hücreli tümör, aksilla, meme

Granular cell tumor presenting as an axillary mass: A case report

Öz

Granular cell tumor (GCT) is a tumor that can arise at virtually any body site. About 5 to 15% of the cases occur in the breast, and it is relatively rare in the axilla. %1-2 of granular cell tumors are malignant. The clinical symptoms and imaging examinations of breast GCTs are non-specific and can easily be confused with malignant tumors. Most are benign and reportedly malignant cases are rare. We report a 59-year-old male with granular cell tumor in axillary region existed approximately 2 years. The palpable mass was around 15mm in diameter and felt clinically suspicious of malignancy. Tru-cut biopsy of the mass showed granular cell tumor features and surgical excision was performed. Early diagnosis and complete resection of the tumor remains the best treatment method. 

Anahtar Kelimeler

Granular cell tumor, axilla, breast

Kaynakça

• 1. Brown AC, Audisio RA, Regitnig P. Granular cell tumour of the breast. Surg Oncol. 2011;20:97–105.
• 2. Chetty R, Kalan MR. Malignant granular cell tumor of the breast. J Surg Oncol 1992;49:135-7.
• 3. A. Adeniran, H. Al-Ahmadie, M. C. Mahoney, and T. M. Robinson-Smith, “Granular cell tumor of the breast: a series of 17 cases and review of the literature, Breast Journal, 2004,10:528–31.
• 4. Ssi-Yan-Kai G, Barthier S, Trichot C, Prevot S, De Laveaucoupet J. Granular cell breast cancer: A rare misleading lesion. Diagn Interv Imaging. 2015;96:287-9.
• 5. Lack EE, Worsham GF, Callihan MD, et al.Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol. 1980;13:301–16.
• 6. Tran TA, Kallakury BV, Carter J, Wolf BC, Ross JS. Coexistence of granular cell tumor and ipsilateral infiltrating ductal carcinoma of the breast. South Med J. 1997;90:1149–51.
• 7. Meani F, Di Lascio S, Wandschneider W, Montagna G, Vitale V, Zehbe S et al. “Granular cell tumor of the breast: a multidisciplinary challenge” Crit Rev Oncol Hematol. 2019;144:102828.
• 8. Kragel PJ, Fiorella RM, Kremer H: Tumoral fibrosis and lack of circumscription in granular cell tumor of the breast. South Med J. 1995;88:1146-8.
• 9. Gupta N, Sanchety N, Verma PS, Verma G. Malignant granular cell tumor of the breast; literature review. Indian J Pathol Microbiol. 2015;58:238-40.
• 10. Liu LS, Leng XL. Ultrasonic manifestation of mammary granular cell tumor report of one case. J Chin Clin Men Imaging 2007;18:578.
• 11. Raju GC, O’Reuilly AP. Immunohistochemical study of granular cell tumour. Pathology. 1987;19:402–6.
• 12. Rekhi B, Jambhekar NA Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center. Ann Diagn Pathol 2010;14:162–7.
• 13. Wang YH, Lee MY. Granular cell tumor in male breast masquerading as atypical apocrine neoplasm: a potential diagnostic pitfall in fine needle aspiration cytology. Diagn Cytopathol. 2016;44:612–5.