Evaluation of the risk of developing atrial fibrillation with new electrocardiographic parameters in patients with primary hyperparathyroidism

Abstract

Aims: Primary hyperparathyroidism (PHPT) is a clinical entity characterized by hypercalcemia caused by excessive parathyroid hormone (PTH) secretion from the parathyroid gland and is the most common cause of hypercalcemia in outpatient clinics. Atrial fibrillation (AF) is a common arrhythmia encountered in cardiology practice, the prevalence of which increases with concomitant heart disease and age. P-wave peak time (PWPT) is the time from the onset of the p-wave to its peak and is a recently defined electrocardiographic (ECG) parameter. Recently, studies on the relationship between PWPT and cardiovascular events have been published. In this study, we aimed to evaluate the risk of AF in PHPT patients by detecting PWPT, a new ECG parameter. Methods: The study included 21 PHPT patients and 20 healthy subjects as a control group. The groups were compared in terms of demographic characteristics, laboratory findings, echocardiography, and ECG findings. D2 and V1 leads were used for PWPT, as recommended in the literature. Results: When the patient group was compared with the control group, no difference was detected in terms of demographic characteristics and laboratory findings. When compared with the control group, patients with PHPT had significantly longer PWPT (PWPTV1 56.07 msec ± 8.33 s vs. 50.25 msec ± 7.00 s p<0.05, PWPTD2 54.57 msec ± 6.28 msec vs. 48.05 msec ± 5.91 msec p<0.01). Conclusion: We observed that PWPT was longer in patients with PHPT compared to controls, and our results suggest that PHPT patients are at risk of AF.

Keywords

• Primary hyperparathyroidism
• hypercalcemia
• atrial fibrillation
• P-wave peak time

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