Can hyperemesis gravidarum influence the reliability of first trimester screening test?

Year 2026, Volume: 8 Issue: 1, 12 - 16, 06.01.2026

Bilal İçer , Fatma Doğa Öcal , Tuncay Küçüközkan

https://doi.org/10.38053/acmj.1803596

Abstract

Aims: The aim of our study was to explore the influence of the variation in plasma volume expansion due to hyperemesis gravidarum (HEG) on the biomarker concentrations and risk assessment in first trimester screening.
Methods: 144 pregnant women who were hospitalized due to HEG between 11 and 14 gestational ages were determined as the study group. 253 pregnant women at a similar gestational age were randomly selected and determined as a control group.
Results: The levels of Hgb, Htc, the MOM values of PAPP-A and β-HCG, the median risk of the double test were statistically higher in the study group when compared to the control group (p<0.05). Multivariate regression analysis for HEG revealed that the PAPP-A, β-HCG, and TSH variables were statistically significant when the six variables were controlled. There was no significant relationship between Hgb and Hct values and biochemical parameters of double test in the groups (p>0.05).
Conclusion: Even though it is not related to hemo-concentration, double test parameters and the combined results of the test changes in pregnant women with HEG. Therefore, we must be more careful when interpreting double test in women with HEG.

Keywords

Hyperemesis gravidarum , PAPP-A , β-HCG

Hiperemezis gravidarum birinci trimester tarama testinin güvenilirliğini etkileyebilir mi?

Abstract

Amaçlar: Çalışmamızın amacı, ilk trimester taramasında Hyperemezis gravidarum (HEG) nedeniyle plazma hacmi genişlemesindeki varyasyonun biyobelirteç konsantrasyonları ve risk değerlendirmesi üzerindeki etkisini araştırmaktı.

Yöntemler: Çalışma grubu olarak 11 ila 14 gebelik yaşları arasında hiperemezis gravidarum nedeniyle hastaneye kaldırılan 144 hamile kadın belirlendi. Benzer gebelik yaşındaki 253 hamile kadın rastgele seçildi ve kontrol grubu olarak belirlendi.

Sonuçlar: Hgb, Htc, PAPP-A ve β-HCG'nin MOM değerleri, çift testin medyan riski, çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak daha yüksekti (p<0,05). HEG için çok değişkenli regresyon analizi, altı değişken kontrol edildiğinde PAPP-A, β-HCG ve TSH değişkenlerinin istatistiksel olarak anlamlı olduğunu ortaya koydu. Gruplarda Hgb ve Hct değerleri ile çift testin biyokimyasal parametreleri arasında anlamlı bir ilişki yoktu (p > 0,05).

Sonuç: Hemo-konsantrasyon ile ilişkili olmasa da, çift test parametreleri ve testin birleşik sonuçları HEG'li hamile kadınlarda değişir. Bu nedenle, HEG'li kadınlarda çift testi yorumlarken daha dikkatli olmalıyız.

Keywords

Hiperemezis Gravidarum , PAPP-A , β-HCG

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