Evaluation of mean platelet volume in patients with thrombophilia
Abstract
Aims: Mean platelet volume (MPV), a commonly accessible hematological metric, has been suggested as an indicator of platelet activation and thrombotic risk. Nonetheless, information concerning its importance in hereditary thrombophilia remains limited.
Methods: This retrospective cross-sectional study comprised 208 patients with thrombophilia and 82 healthy controls. Clinical and laboratory data were obtained from medical records. MPV values were compared across groups.
Results: MPV levels were significantly higher in patients with thrombophilia than in healthy controls (7.66±1.52 fL vs. 7.25±1.41 fL, p=0.028). MPV showed a significant negative correlation with platelet count (r=-0.327, p=0.008), and the receiver operating characteristic analysis yielded an area under the curve of 0.682. Results indicated a modest diagnostic performance of MPV in distinguishing patients with thrombophilia from healthy controls.
Conclusions: Patients with thrombophilia had higher MPV values than healthy controls. Although MPV alone showed limited diagnostic utility, the observed findings suggest a potential association between inherited thrombophilia and platelet-related alterations. Further prospective studies are necessary to ascertain the clinical significance of MPV in assessing thrombotic risk.
Keywords
Supporting Institution
The authors conducted this research without receiving external financial support.
Project Number
Not Applicable
Ethical Statement
Ethical approval was secured by the Clinical Research Ethics Committee of Erzurum Regional Training and Research Hospital (Approval No: 2017/08-74; Approval Date: June 21, 2017).
Thanks
The authors would like to thank all participants involved in the study.
References
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Details
Primary Language
English
Subjects
Haematology
Journal Section
Research Article
Publication Date
September 11, 2026
Submission Date
June 24, 2026
Acceptance Date
July 28, 2026
Published in Issue
Year 2026 Volume: 8 Number: 5
APA
Kılıç, A. F., Akkaş, N., & Çadırcı, K. (2026). Evaluation of mean platelet volume in patients with thrombophilia. Anatolian Current Medical Journal, 8(5), 941-945. https://doi.org/10.38053/acmj.1978517
AMA
1.Kılıç AF, Akkaş N, Çadırcı K. Evaluation of mean platelet volume in patients with thrombophilia. Anatolian Curr Med J / ACMJ / acmj. 2026;8(5):941-945. doi:10.38053/acmj.1978517
Chicago
Kılıç, Adil Furkan, Nagihan Akkaş, and Kenan Çadırcı. 2026. “Evaluation of Mean Platelet Volume in Patients With Thrombophilia”. Anatolian Current Medical Journal 8 (5): 941-45. https://doi.org/10.38053/acmj.1978517.
EndNote
Kılıç AF, Akkaş N, Çadırcı K (September 1, 2026) Evaluation of mean platelet volume in patients with thrombophilia. Anatolian Current Medical Journal 8 5 941–945.
IEEE
[1]A. F. Kılıç, N. Akkaş, and K. Çadırcı, “Evaluation of mean platelet volume in patients with thrombophilia”, Anatolian Curr Med J / ACMJ / acmj, vol. 8, no. 5, pp. 941–945, Sept. 2026, doi: 10.38053/acmj.1978517.
ISNAD
Kılıç, Adil Furkan - Akkaş, Nagihan - Çadırcı, Kenan. “Evaluation of Mean Platelet Volume in Patients With Thrombophilia”. Anatolian Current Medical Journal 8/5 (September 1, 2026): 941-945. https://doi.org/10.38053/acmj.1978517.
JAMA
1.Kılıç AF, Akkaş N, Çadırcı K. Evaluation of mean platelet volume in patients with thrombophilia. Anatolian Curr Med J / ACMJ / acmj. 2026;8:941–945.
MLA
Kılıç, Adil Furkan, et al. “Evaluation of Mean Platelet Volume in Patients With Thrombophilia”. Anatolian Current Medical Journal, vol. 8, no. 5, Sept. 2026, pp. 941-5, doi:10.38053/acmj.1978517.
Vancouver
1.Adil Furkan Kılıç, Nagihan Akkaş, Kenan Çadırcı. Evaluation of mean platelet volume in patients with thrombophilia. Anatolian Curr Med J / ACMJ / acmj. 2026 Sep. 1;8(5):941-5. doi:10.38053/acmj.1978517
