Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study

Aslı Odabaşı Giden; Neslihan Kayahan

Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study

Abstract

Aims: To investigate the association between nutritional status and health-related quality of life (HRQoL) in patients with multiple myeloma (MM) using validated nutritional and disease-specific quality-of-life instruments. Methods: This single-center cross-sectional study included 67 adult patients with MM. Nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF). HRQoL was evaluated using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and the EORTC QLQ-MY20 module. Group comparisons, Spearman correlation, and multivariable linear regression analyses adjusted for clinically relevant covariates were performed. Results: The median MNA-SF score was 10 (IQR, 8-13); 37.3% of patients had normal nutritional status, 40.3% were at risk of malnutrition, and 22.4% were malnourished. Poorer nutritional status was associated with significantly lower Global Health Status and worse physical, role, emotional, cognitive, and social functioning (all p≤0.001). Symptom burden increased significantly with worsening nutritional status. MNA-SF scores correlated positively with Global Health Status (ρ=0.296, p=0.015) and remained independently associated with Global Health Status after adjustment for ECOG performance status, hemoglobin level, treatment status, disease duration, body mass-index, and serum albumin (β=2.19, 95% CI 0.58-3.81; p=0.008). Conclusion: Impaired nutritional status was independently associated with poorer HRQoL in patients with MM. Routine nutritional screening using the MNA-SF may facilitate early identification of patients at risk for functional decline and impaired quality of life, supporting individualized supportive care.

Keywords

Ethical Statement

The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Non-Interventional Scientific Research Ethics Committee of Ordu University (Approval No. 2026/107, Date: 29 April 2026).

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Details

Primary Language

English

Subjects

Haematological Tumours

Journal Section

Research Article

Authors

Aslı Odabaşı Giden ^*
0000-0001-7375-4485
Türkiye

Neslihan Kayahan
0000-0002-6802-7926
Türkiye

Publication Date

October 25, 2026

Submission Date

July 24, 2026

Acceptance Date

August 28, 2026

Published in Issue

Year 2026 Volume: 8 Number: 6

IZ

https://izlik.org/JA55XL78MB

Cite

RIS / Bibtex

APA

Odabaşı Giden, A., & Kayahan, N. (2026). Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study. Anatolian Current Medical Journal, 8(6), 1184-1192. https://izlik.org/JA55XL78MB

AMA

1.Odabaşı Giden A, Kayahan N. Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study. Anatolian Curr Med J / ACMJ / acmj. 2026;8(6):1184-1192. https://izlik.org/JA55XL78MB

Chicago

Odabaşı Giden, Aslı, and Neslihan Kayahan. 2026. “Impact of Nutritional Status on Health-Related Quality of Life in Patients With Multiple Myeloma: A Cross-Sectional Study”. Anatolian Current Medical Journal 8 (6): 1184-92. https://izlik.org/JA55XL78MB.

EndNote

Odabaşı Giden A, Kayahan N (October 1, 2026) Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study. Anatolian Current Medical Journal 8 6 1184–1192.

IEEE

[1]A. Odabaşı Giden and N. Kayahan, “Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study”, Anatolian Curr Med J / ACMJ / acmj, vol. 8, no. 6, pp. 1184–1192, Oct. 2026, [Online]. Available: https://izlik.org/JA55XL78MB

ISNAD

Odabaşı Giden, Aslı - Kayahan, Neslihan. “Impact of Nutritional Status on Health-Related Quality of Life in Patients With Multiple Myeloma: A Cross-Sectional Study”. Anatolian Current Medical Journal 8/6 (October 1, 2026): 1184-1192. https://izlik.org/JA55XL78MB.

JAMA

1.Odabaşı Giden A, Kayahan N. Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study. Anatolian Curr Med J / ACMJ / acmj. 2026;8:1184–1192.

MLA

Odabaşı Giden, Aslı, and Neslihan Kayahan. “Impact of Nutritional Status on Health-Related Quality of Life in Patients With Multiple Myeloma: A Cross-Sectional Study”. Anatolian Current Medical Journal, vol. 8, no. 6, Oct. 2026, pp. 1184-92, https://izlik.org/JA55XL78MB.

Vancouver

1.Aslı Odabaşı Giden, Neslihan Kayahan. Impact of nutritional status on health-related quality of life in patients with multiple myeloma: a cross-sectional study. Anatolian Curr Med J / ACMJ / acmj [Internet]. 2026 Oct. 1;8(6):1184-92. Available from: https://izlik.org/JA55XL78MB