Evaluation of oxidative stress in pregnants with chronic hepatitis B and C

Abstract

Aim: This study was aimed to investigate the levels of antioxidant markers (paraoxonase, superoxide dismutase, glutathione peroxidase, and thiol) and oxidative stress markers (advanced oxidation protein products, xanthin oxidase, nitric oxide, malondialdehyde, and 8-hydroxydeoxyguanosine) in pregnant women with chronic hepatitis B and C. Material and Method: Sixty pregnant women in the last trimester, 20 of whom had chronic hepatitis B, another 20 of whom had chronic hepatitis C, and the remaining 20 of whom were healthy controls, were enrolled in this study. Demographic, clinical and laboratory data were recorded for all patients. Results: When compared to the healthy controls, the pregnant women with chronic hepatitis B and C displayed significantly lower levels of paraoxonase, glutathione peroxidase, and thiol (p<0.001). Superoxide dismutase levels were also lower in the chronic hepatitis B and C patients, in comparison to the healthy controls, yet this difference was statistically insignificant (p=0.76). Compared to the healthy controls, the chronic hepatitis B and C patients had significantly higher levels of advanced oxidation protein and xanthine oxidase (p<0.001). The nitric oxide levels of the chronic hepatitis B and C patients were significantly lower than those of the control group (p<0.05). No statistically significant difference was observed between the chronic hepatitis B and C patients and the controls for malondialdehyde and 8-hydroxydeoxyguanosine levels (p>0.05). Conclusion: Oxidative stress had significantly increased in pregnant women chronically infected with the hepatitis B and C viruses, when compared to healthy pregnant women. Thus, we suggest that pregnant women chronically infected with the hepatitis B and C viruses should be closely monitored throughout pregnancy for diseases induced by oxidant-antioxidant imbalance, such as preeclampsia, gestational diabetes and gestational hypertension.

Keywords

• Antioxidant activity
• chronic hepatitis B
• chronic hepatitis C
• oxidative stress
• pregnancy

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