Tigecycline induced acute pancreatitis: Suspicion is the first step in diagnosis

Abstract

Acute pancreatitis is an inflammatory event of the pancreas which may affect seriously all other tissues and organ systems. Generally, acute pancreatitis is induced by alcoholism or gallstones. However pathogenetic mechanisms of drug induced pancreatitis are not clearly understood. A minocycline derivative, tigecycline is a glycylcycline class of antibiotic which is structurally similar to the tetracyclines. It has perfect tissue and organ distribution and favorable microbial coverage, including many kind of Gram-positive and Gram-negative bacteria and also anaerob agents. Tigecycline’s side-effect profile is similar to the tetracyclines. Pancreatitis is a well-known adverse effect of tetracyclines. However, tigecycline-induced pancreatitis is an uncommon side-effect. We report here a rare case of tigecycline-induced pancreatitis during the treatment of a diabetic food infection.

Keywords

• Tigecycline
• acute pancreatitis
• advers effect

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