A new cystatin C based model for predicting COVID-19- associated mortality
Abstract
Background: This study aimed to investigate the effect of the Cystatin C based model on kidney function and the value of this model on predicting mortality in patients with the recent novel coronavirus disease (COVID-19).
Methods: Demographic characteristics, clinical manifestations, and laboratory measurements were measured in critically ill patients with COVID-19 infection. Patients were monitored until they were discharged from the hospital or died.
Results: 105 patients participated in this study. 29 of 105 patients were treated in the intensive care unit. Acute kidney injury developed in nearly all of these patients and developed in 6 other non-intensive care unit patients. 21 of the patients in the intensive care unit had exitus.
Conclusion: The cystatin C (sCys C )based model may be used to predict mortality in severe COVID-19 infections.
Keywords
Kaynakça
- 1. Hirsch JS, Ng JH, Ross DW, Northwell COVID-19 Research Consortium; Northwell Nephrology COVID-19 Research Consortium. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int 2020; 98: 209-218
- 2. Guven G, Ince C, Topeli A. Cardio-Pulmonary-Renal Consequences of Severe COVID-19. Cardiorenal Med. 2021;11(3):133-139.
- 3. Laterza OF, Price CP, Scott MG. Cystatin C: an improved estimator of glomerular filtration rate? Clin Chem. 2002;48(5):699-707.
- 4. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002;40:221–6.
- 5. Roos JF, Doust J, Tett SE. Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children a meta-analysis. Clin Biochem. 2007;40:383–91.
- 6. Shlipak MG, Sarnak MJ, Katz R. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352:2049–60. 7. Ni L, Lü J, Hou LB. Cystatin C, associated with hemorrhagic and ischemic stroke, is a strong predictor of the risk of cardiovascular events and death in Chinese. Stroke. 2007; 38:3287–8.
- 8. World Health Organization, Clinical management of severe acute respiratory infection when novel coronavirus (2019- nCoV) infection is suspected: interim guidance, World Health Organization, 2020, Published January 2020.
- 9. Pei G, Zhang Z, Peng J. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. J Am Soc Nephrol. 2020;31(6):1157-1165
- 10. Eknoyan G, Lameire N, Eckardt K. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidny Int Suppl. 2013;3(1):1-150.
- 11. Mathisen UD, Melsom T, Ingebretsen OC. Estimated GFR associates with cardio vascular risk factors independently of measured GFR. J Am Soc Nephrol. 2011;22(5):927-937.