Risk of morbidity and mortality in preterm infants born to advanced maternal age pregnancies
Abstract
Background: Little is known about the effect of advanced maternal age on preterm morbidity and mortality. This study aimed to evaluate the possible relationship between maternal age and morbidity and mortality in premature infants born at a gestational age ≤32 weeks.
Methods: Premature infants born at ≤32 weeks of gestation and admitted to the neonatal intensive care unit were divided into three groups by maternal age: <35, 35-39, and ≥40 years. Infant and maternal demographic and clinical characteristics, and preterm morbidity and mortality were compared between the groups.
Results: A total of 827 preterm infants were included. Their distribution by maternal age was as follows: 659 infants in the <35 years group, 120 in the 35-39 years group, and 48 in the ≥40 years age group. Older maternal age was associated with higher gravidity, frequency of assisted reproductive technology use, preeclampsia, gestational diabetes mellitus, and caesarean delivery (P=0.004, P<0.001, P=0.007, P=0.004, and P<0.001, respectively). Respiratory distress syndrome, patent ductus arteriosus, and necrotising enterocolitis were significantly more frequent in preterm infants aged ≥35 years (P=0.014, P=0.029, and P<0.001, respectively).
Conclusions: In addition to the maternal risks associated with pregnancy at older ages, some prematurity morbidities may also increase in frequency. Although this novel study presents important results, further studies are needed to evaluate the relationship between advanced maternal age and preterm morbidity.
Keywords
Maternal age , Preterm infants , Morbidity , Mortality , Aged
Kaynakça
- 1. Correa-de-Araujo R, Yoon SSS. Clinical Outcomes in High-Risk Pregnancies Due to Advanced Maternal Age. J Womens Health (Larchmt). 2021;30(2):160-167.
- 2. van Roode T, Sharples K, Dickson N, Paul C. Life-Course Relationship between Socioeconomic Circumstances and Timing of First Birth in a Birth Cohort. PLoS One. 2017;12(1):e0170170.
- 3. Lee S, Holden D, Webb R, Ayers S. Pregnancy related risk perception in pregnant women, midwives & doctors: a cross-sectional survey. BMC Pregnancy Childbirth. 2019;19(1):335.
- 4. Abdou CM. Age-Based Reproductive Healthcare Stereotype Threat (HCST) as a Stressor Affecting Prenatal Mental Health in Pregnant Women of Advanced Maternal Age: Measurement, Process, Outcomes, and Interactions with Ethnicity/Race, SES, and Other Social Identities. Curr Epidemiol Rep. 2017;4(2):133-144.
- 5. Dinçgez Çakmak B, Dündar B, Türker ÜA. Perinatal Outcomes of Advanced and Extremely Advanced Maternal Age Pregnancies. Med Bull Haseki. 2019;57(4):366-371.
- 6. van Katwijk C, Peeters LL. Clinical aspects of pregnancy after the age of 35 years: a review of the literature. Hum Reprod Update. 1998;4(2):185-194.
- 7. Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ. 2010;88(1):31-38.
- 8. Fenton TR. A new growth chart for preterm babies: Babson and Benda’s chart updated with recent data and a new format. BMC Pediatr. 2003;3:13.
- 9. Cakir U, Tayman C, Buyuktiryaki M, Unsal H, Ozer Bekmez B. Do Calcium and Potassium Levels Influence Ductal Patency in Preterm Infants? Am J Perinatol. 2020;37(11):1123-1129.
- 10. Cakir U, Tayman C, Yucel C. A Novel Diagnostic Marker for the Severity of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants: Interleukin-33. Pediatr Allergy Immunol Pulmonol. 2019;32(1):12-17.