Is Hot-shot Cardioplegia Necessary in Cardiac Surgery with Cardiopulmonary Bypass?
Öz
Background: Many solutions and techniques have been developed to protect the myocardium during cardiac surgery with cardiopulmonary bypass. Hot-shot cardioplegia is given during removal of the aortic cross-clamp, i.e. during restart of the heart, but its necessity and additional benefit are controversial. The aim of this retrospective study was to evaluate the necessity and/or extra benefit of hot-shot cardioplegia administration and early clinical outcomes in patients undergoing cardiac surgery with cardiopulmonary bypass.
Methods: This retrospective study included a total of 686 patients who underwent cardiac surgery with cardiopulmonary bypass. The study groups were defined as patients without hot-shot cardioplegia (Group 1) and patients with hot-shot cardioplegia (Group 2). Descriptive data and early clinical outcomes of the groups were compared.
Results: Demographic and descriptive data of the patients included in the study were similar in both groups (p > 0.05). There was no difference between the groups in potassium levels, Creatine Kinase-Myocardial Bound and Cardiac Troponin T levels indicative of myocardial necrosis, and Carbohydrate Reactive Protein levels indicative of inflammation (p > 0.05). In addition, there was no difference in the need for intracardiac defibrillation, inotrope requirement during cardiopulmonary bypass weaning, intra-aortic balloon pump requirement, early postoperative arrhythmia, atrial fibrillation, duration of mechanical ventilation, intensive care unit stay, hospital stay and mortality rates (p > 0.05).
Conclusion: In conclusion, it is thought that hot-shot cardioplegia application does not provide any additional benefit in preventing myocardial damage or in postoperative clinical and metabolic markers in cardiac surgery performed with cardiopulmonary bypass.
Anahtar Kelimeler
Cardiopulmonary Bypass, Cardioplegia, Hot-Shot, Terminal Hot Blood Cardioplegia
Destekleyen Kurum
The authors received no financial support for the research and/or authorship of this article. There is no funding source.
Etik Beyan
In this study, approval was obtained from the institution and the local ethics committee before the study (Harran University Clinical Research Ethics Committee) (Date: 30.12.2024 - Approval no: HRÜ/24.21.11). The study was conducted following the principles of the Declaration of Helsinki. Since only anonymized patient data was used and there was no risk or impact on patient care, informed consent was not required. This consent waiver was approved by the Institutional Review Board and Ethics Committee and complies with regulatory and ethical guidelines for retrospective studies.
Teşekkür
None
Kaynakça
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