The Value of Serum Cardiac Myosin Binding Protein C (cMyBP-C) Levels in Detecting Cardiac Contusion in an Experimental Blunt Thoracic Trauma Model
Öz
Background: The aim of this study is to investigate the usability of Cardiac Myosin Binding Protein C (cMyBP-C) as a marker in demonstrating cardiac damage in the blunt thoracic trauma model.
Methods: It was provided in the trauma groups bilateral blunt thoracic trauma (3.31 joules to the low-energy trauma group, 6.62 joules to the medium-energy trauma group, 9.93 jouls to the high-energy trauma group). Blood samples were taken 0th, 12th and 24th hours to examine cMyBP-C levels from the subjects. At the end of the experiment (24th hour), lung tissues were taken from the subjects for histopathological examination.
Results: The mean cMyBP-C levels of the trauma groups at the 24th hour were statistically significantly higher than the control group (p=0.02). The mean cMyBP-C levels at the 24th hour of the low-energy trauma group, the 0th hour of the medium-energy trauma group, and the 12th and 24th hours of the high-energy trauma group were significantly higher than the control group (p=0.004, 0.007, 0.02, 0.03 respectively). A significant positive correlation was found in the bilateral correlation analysis between the contusion levels at 0th and 24th hours and cMyBP-C levels of the trauma groups (Spearman’s ρ= 0.396, p=0.04, spearman’s ρ= 0.473, p=0.01, respectively) . It was determined that the 24th hour cMyBP-C values (ng/ml)
the sensitivity and specificity was 83.3% at the cut-off value of 11,150.
Conclusion: cMyBP-C levels increase in cardiac contusion due to blunt thoracic trauma. However, more comprehensive experimental and clinical studies are required for the use of cMyBP-C as a biomarker in the diagnosis of cardiac contusion due to blunt thoracic trauma.
Anahtar Kelimeler
Cardiac Myosin Binding Protein C, myocardial injury, biomarkers, chest trauma
Destekleyen Kurum
Selçuk University Scientific Research Projects Coordinatorship supported this study with project number 21401109.
Proje Numarası
21401109
Etik Beyan
Ethics committee permission was obtained from Selçuk University Experimental Medicine Research and Application Center Animal Experiments Local Ethics Committee with the date of 26.03.2021 and decision number 2021-28.
Kaynakça
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