The Value of Serum Cardiac Myosin Binding Protein C (cMyBP-C) Levels in Detecting Cardiac Contusion in an Experimental Blunt Thoracic Trauma Model
Abstract
Background: The aim of this study is to investigate the usability of Cardiac Myosin Binding Protein C (cMyBP-C) as a marker in demonstrating cardiac damage in the blunt thoracic trauma model.
Methods: It was provided in the trauma groups bilateral blunt thoracic trauma (3.31 joules to the low-energy trauma group, 6.62 joules to the medium-energy trauma group, 9.93 jouls to the high-energy trauma group). Blood samples were taken 0th, 12th and 24th hours to examine cMyBP-C levels from the subjects. At the end of the experiment (24th hour), lung tissues were taken from the subjects for histopathological examination.
Results: The mean cMyBP-C levels of the trauma groups at the 24th hour were statistically significantly higher than the control group (p=0.02). The mean cMyBP-C levels at the 24th hour of the low-energy trauma group, the 0th hour of the medium-energy trauma group, and the 12th and 24th hours of the high-energy trauma group were significantly higher than the control group (p=0.004, 0.007, 0.02, 0.03 respectively). A significant positive correlation was found in the bilateral correlation analysis between the contusion levels at 0th and 24th hours and cMyBP-C levels of the trauma groups (Spearman’s ρ= 0.396, p=0.04, spearman’s ρ= 0.473, p=0.01, respectively) . It was determined that the 24th hour cMyBP-C values (ng/ml)
the sensitivity and specificity was 83.3% at the cut-off value of 11,150.
Conclusion: cMyBP-C levels increase in cardiac contusion due to blunt thoracic trauma. However, more comprehensive experimental and clinical studies are required for the use of cMyBP-C as a biomarker in the diagnosis of cardiac contusion due to blunt thoracic trauma.
Keywords
Cardiac Myosin Binding Protein C , myocardial injury , biomarkers , chest trauma
Kaynakça
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