The Impact of Modified Frailty Index-5 on Postoperative Outcomes and Survival in Patients Undergoing Pneumonectomy
Öz
Background: Pneumonectomy is a major surgical procedure for central lung cancers but is associated with high morbidity and mortality. This study aimed to evaluate the association between the Modified Frailty Index-5 (mFI-5) score and major postoperative complications and overall survival in patients undergoing pneumonectomy.
Methods: Seventy-four patients who underwent pneumonectomy for non–small cell lung cancer were retrospectivelyreviewed. Patients undergoing pneumonectomy for benign pathologies or non-NSCLC indications were excluded to maintain a homogeneous oncological cohort. The mFI-5 scores were calculated based on five parameters: diabetes, hypertension, heart failure, COPD, and functional dependence. Major complications were defined as Clavien–Dindo Grade ≥3. Independent prognostic factors were identified using multivariable logistic and Cox regression models.
Results: The mean age was 59.1 ± 10.6 years, and 85.1% were male. Major postoperative complications occurred in 28.4% of patients. In multivariable analysis, mFI-5 was not independently associated with major postoperative complications. However, higher mFI-5 scores were independently associated with reduced overall survival (HR = 1.428, p = 0.048). The development of postoperative complications was the sole independent determinant of both intensive care unit and hospital length of stay.
Conclusion: The mFI-5 score appears to be a practical and clinically accessible tool for preoperative risk stratification in pneumonectomy candidates. However, given the retrospective design and limited sample size, these findings should be interpreted with caution. mFI-5 may serve as a supportive parameter in identifying high-risk patients and guiding perioperative management strategies.
Anahtar Kelimeler
Pneumonectomy, Modified Frailty Index-5, Postoperative Complications, Lung Cancer, Survival
Destekleyen Kurum
Bu çalışma için herhangi bir kurumdan finansal destek alınmamıştır.
Proje Numarası
None
Etik Beyan
Bu çalışma Helsinki Deklarasyonu’na uygun olarak gerçekleştirilmiştir. Çalışma protokolü Ankara Abdurrahman Yurtaslan Onkoloji Eğitim ve Araştırma Hastanesi Etik Kurulu tarafından onaylanmıştır (Onay No: 2025-06/96). Çalışmanın retrospektif tasarımı nedeniyle bilgilendirilmiş onam şartı etik kurul tarafından kaldırılmıştır.
Teşekkür
Teşekkür beyanı yoktur.
Kaynakça
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