The Role of Irisin, Copper and Zinc Levels on Insulin Resistance in Polycystic Ovary Syndrome

Mustafa Bayraktar; Ali Sami Gürbüz; Bahadır Öztürk

doi:10.47482/acmr.2020.2

EN

The Role of Irisin, Copper and Zinc Levels on Insulin Resistance in Polycystic Ovary Syndrome

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Irisin is defined as a myocin released from skeletal muscle that protects individuals from metabolic diseases when exercised regularly. Zinc is thought to play an active role in the pathophysiology of PCOS in relation to insulin resistance. Copper has been stated to contribute to oxidative stress and insulin resistance in PCOS patients. The aim of this study was to evaluate the relationship between serum irisin, copper and zinc levels and insulin resistance in PCOS patients and control cases. Methods: Our study consists of a patient group of 45 individuals diagnosed with PCOS and a healthy control group of 45 individuals. 2003 Rotterdam diagnostic criteria were used for the diagnosis of PCOS. Serum copper, zinc and irisin levels were measured and evaluated with regard to Body Mass Index and insulin resistance. Results: Serum zinc and copper levels were found to be higher in PCOS patients compared to controls (p<0.05), however no statistically significant differences were found between the groups with regard to HOMA-IR and serum irisin levels. Conclusions: It was evaluated that the data obtained from the patient group in this study may have been effected due to patients’ use of some medications like metformin, multivitamin supplements and oral contraceptives.

Keywords

PCOS , Irisin , Insulin Resistance , Copper , Zinc

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Klinik Araştırma

Yazarlar

Mustafa Bayraktar ^* Bu kişi benim
0000-0002-5568-1945
Türkiye

Ali Sami Gürbüz Bu kişi benim
0000-0001-7747-3074
Türkiye

Bahadır Öztürk Bu kişi benim
0000-0003-2654-7621
Türkiye

Yayımlanma Tarihi

22 Eylül 2020

Gönderilme Tarihi

29 Ağustos 2020

Kabul Tarihi

19 Ağustos 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 1 Sayı: 1

DOI

https://doi.org/10.47482/acmr.2020.2

IZ

https://izlik.org/JA66CA84PS

APA

Bayraktar, M., Gürbüz, A. S., & Öztürk, B. (2020). The Role of Irisin, Copper and Zinc Levels on Insulin Resistance in Polycystic Ovary Syndrome. Archives of Current Medical Research, 1(1), 12-18. https://doi.org/10.47482/acmr.2020.2

Cited By

Assessment of Serum Elements Concentration and Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis

Biological Trace Element Research

https://doi.org/10.1007/s12011-021-03058-6

The interplay between oxidative stress, zinc, and metabolic dysfunction in polycystic ovarian syndrome

Molecular and Cellular Biochemistry

https://doi.org/10.1007/s11010-024-05113-x

Archives of Current Medical Research (ACMR), araştırmaları ücretsiz sunmanın daha büyük bir küresel bilgi alışverişini desteklediğini göz önünde bulundurarak, tüm içeriğe anında açık erişim sağlar. Kamunun erişimine açık olması, daha büyük bir küresel bilgi alışverişini destekler.

http://www.acmronline.org/

The Role of Irisin, Copper and Zinc Levels on Insulin Resistance in Polycystic Ovary Syndrome

Abstract

Keywords

Öz

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

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Yayımlandığı Sayı

DOI

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Cited By

Assessment of Serum Elements Concentration and Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis

The interplay between oxidative stress, zinc, and metabolic dysfunction in polycystic ovarian syndrome