Predictive role of NLR, SII, and PLR in COVID-19 patient mortality and disease severity
Abstract
Background: In this study, it was aimed to evaluate the factors affecting the prognosis and mortality of patients hospitalized for coronavirus disease 2019 (COVID-19).
Methods: Patients hospitalized with COVID-19 infection between March and November 2020 were examined retrospectively. The Systemic Immune-Inflammation Index (SII), platelet lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR) values were evaluated for their effect on prognosis.
Results: Of the 1013 patients included in the study, 204 (20.1%) had a severe infection. In the multivariate analysis, it was determined that the prognosis was significantly worse in patients who were >65 years of age, had a Charlson Comorbidity Index (CCI) score of >2, and had a high NLR rate. The C-reactive protein (CRP), PLR, SII values were detected as insignificant variables. Mortality was found to be statistically significant in patients with a CCI score of 2 or more and in patients with high CRP, NLR, PLR, and SII values at the time of admission (p<0.05) in the multivariate analysis.
Conclusions: It was found that the most important factor affecting the severity of the disease was advanced age and high comorbidities, and a high NLR value. The most important prognostic factors affecting mortality were high levels of comorbidities, and high NLR, PLR, SII, and CRP values.
Keywords
COVID-19 , Mortality , Prognosis , Systemic immune-inflammation index , Neutrophil Lymphocyte Ratio
Kaynakça
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