Klinik Araştırma
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Mean Platelet Volume and Red Cell Distribution Width Values in Patients with COVID-19 Admitted to Intensive Care Units or Wards from Emergency Department

Yıl 2021, Cilt 2, Sayı 2, 88 - 92, 05.05.2021
https://doi.org/10.47482/acmr.2021.20

Öz

Background: Mean platelet volume (MPV) and red cell distribution width (RDW) values are components of complete blood count (CBC) which is a routine, cheap and fast test used in the evaluation of patients admitted to the emergency department (ED). The present study aimed to investigate RDW and MPV values in patients with Novel Coronavirus Disease 2019 (COVID-19) admitted to intensive care units (ICU) or wards from the ED. Methods: A retrospective data analysis of patients who were admitted to Ankara City Hospital ICUs and wards with the diagnosis of COVID-19 was performed. Group 1 included patients admitted to ICUs and Group 2 included those admitted to wards. Results: A total of 127 patients were admitted with a COVID-19 diagnosis. Mean age in Group 1 and Group 2 were 46±17 and 41±14, respectively. The number of patients admitted to ICU (Group 1) was 46 (36.2%), and the number of patients admitted to wards (Group 2) was 81 (63.7%). Of all patients, 122 patients (96.06%) were discharged and 5 patients (3.9%) died. RDW values in Group 1 was higher than those in Group 2 (p<0,001). Similarly, MPV was higher in Group 1 than Group 2 (p<0,001). Conclusion: In patients with COVID-19, RDW and MPV values are higher in those admitted to ICU than patients admitted to wards from the ED.

Kaynakça

  • 1. WHO. Rolling updates on coronavirus disease (COVID-19). Available at: https://www.who.int/emergencies/diseases/novelcoronavirus-2019/events-as-they-happen. Accessed February 26, 2021.
  • 2. Sözen M, Karaköse M, Erayman İ, Demirbaş S, Teke T, Çölkesen F, et.al. Are patients with diabetes mellitus at increased risk of COVID-19 infection? Arch Curr Med Res 2021; 2(1):38-44.
  • 3. Erganiş S, Bozdayı G. Virology, immunity and vaccine development of SARS-CoV-2. Arch Curr Med Res 2021; 2(1):05-13.
  • 4. Tenda ED, Asaf MM. Diagnosing COVID-19: Did we miss anything? Acta Med Indones. 2020;52(1):1-4.
  • 5. Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med. 2020;25;58(7):1063-1069.
  • 6. Henry BM, De Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;25;58(7):1021-1028.
  • 7. Speth C, Löffler J, Krappmann S, Lass-Flörl C, Rambach G. Platelets as immune cells in infectious diseases. Future Microbiol. 2013;8(11):1431-51.
  • 8. Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 2012;44(8):805-16.
  • 9. Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, DymickaPiekarska V. Mean Platelet Volume (MPV): New perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 2019;17;2019:9213074.
  • 10. Güçlü E, Kocayiğit H, Okan HD, Erkorkmaz U, Yürümez Y, Yaylacı S, et al. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras. 2020;66(8):1122-1127.
  • 11. Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015;52(2):86-105.
  • 12. Henry BM, Benoit JL, Benoit S, Pulvino C, Berger BA, Olivera MHS, et al. Red blood cell distribution width (RDW) predicts COVID-19 severity: A prospective, observational study from the cincinnati SARS-CoV-2 emergency department cohort. Diagnostics (Basel). 2020;21;10(9):E618
  • 13. WHO. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: Interim guidance. Available at: https://apps.who.int/iris/bitstream/handle/10665/331446/ WHO-2019-nCoV-clinical-2020.4-eng.pdf?sequence=1&isAllowed=y . Accessed September 23, 2020.
  • 14. Gong J, Ou J, Qiu X, Jie Y, Chen Y, Yuan L, et al. A tool for early prediction of severe coronavirus disease 2019 (COVID-19): A multicenter study using the risk nomogram in Wuhan and Guangdong, China. Clin Infect Dis. 2020;28;71(15):833-840.
  • 15. Zheng Y, Zhang Y, Chi H, Chen S, Peng M, Luo L, et al. The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study. Clin Chem Lab Med. 2020;25;58(7):1106-1115.
  • 16. Skevaki C, Fragkou PC, Cheng C, Xie M, Renz H. Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus. J Infect. 2020;81(2):205-212.
  • 17. Topaz G, Kitay-Cohen Y, Peled L, Gharra W, Kaminer K, Eitan M, et al. The association between red cell distribution width and poor outcomes in hospitalized patients with influenza. J Crit Care. 2017;41:166-169.
  • 18. Braun E, Domany E, Kenig Y, Mazor Y, Makhoul BF, Azzam ZS. Elevated red cell distribution width predicts poor outcome in young patients with community acquired pneumonia. Crit Care. 2011;11;15(4):R194.
  • 19. Kim CH, Park JT, Kim EJ, Han JH, Han JS, Choi JY, et al. An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock. Critical Care 2013;17:R282.
  • 20. Pourbagheri-Sigaroodi A, Bashash D, Fateh F, Abolghasemi H. Laboratory findings in COVID-19 diagnosis and prognosis. Clin Chim Acta. 2020 Aug 14;510:475-482.
  • 21. Semba RD, Patel KV, Ferrucci L, Sun K, Roy CN, Guralnik JM, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women’s Health and Aging Study I. Clin Nutr. 2010;29(5):600-4.
  • 22. Scharte M, Fink MP. Red blood cell physiology in critical illness. Crit Care Med. 2003;31(12 Suppl):S651-7.
  • 23. Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB. Red cell distribution width and all-cause mortality in critically ill patients. Crit Care Med. 2011;39(8):1913-21.
  • 24. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A metaanalysis. Clin Chim Acta. 2020;506:145-148.
  • 25. Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S, Cengiz AB, Ceyhan M. The value of mean platelet volume in the determination of community acquired pneumonia in children. Ital J Pediatr. 2013;8;39:16.
  • 26. Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A. The role of biomarkers in diagnosis of COVID-19 - A systematic review. Life Sci. 2020;1;254:117788.
  • 27. Bao C, Tao X, Cui W, Yi B, Pan T, Young KH, et al. W. SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients. Exp Hematol Oncol. 2020;17;9:16.
  • 28. Hottz ED, Bozza FA, Bozza PT. platelets in immune response to virus and immunopathology of viral infections. Front Med (Lausanne). 2018;30;5:121.
  • 29. Salamanna F, Maglio M, Landini MP, Fini M. Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (COVID-19). Platelets. 2020;3;31(5):627-632.

Yıl 2021, Cilt 2, Sayı 2, 88 - 92, 05.05.2021
https://doi.org/10.47482/acmr.2021.20

Öz

Kaynakça

  • 1. WHO. Rolling updates on coronavirus disease (COVID-19). Available at: https://www.who.int/emergencies/diseases/novelcoronavirus-2019/events-as-they-happen. Accessed February 26, 2021.
  • 2. Sözen M, Karaköse M, Erayman İ, Demirbaş S, Teke T, Çölkesen F, et.al. Are patients with diabetes mellitus at increased risk of COVID-19 infection? Arch Curr Med Res 2021; 2(1):38-44.
  • 3. Erganiş S, Bozdayı G. Virology, immunity and vaccine development of SARS-CoV-2. Arch Curr Med Res 2021; 2(1):05-13.
  • 4. Tenda ED, Asaf MM. Diagnosing COVID-19: Did we miss anything? Acta Med Indones. 2020;52(1):1-4.
  • 5. Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med. 2020;25;58(7):1063-1069.
  • 6. Henry BM, De Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;25;58(7):1021-1028.
  • 7. Speth C, Löffler J, Krappmann S, Lass-Flörl C, Rambach G. Platelets as immune cells in infectious diseases. Future Microbiol. 2013;8(11):1431-51.
  • 8. Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 2012;44(8):805-16.
  • 9. Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, DymickaPiekarska V. Mean Platelet Volume (MPV): New perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 2019;17;2019:9213074.
  • 10. Güçlü E, Kocayiğit H, Okan HD, Erkorkmaz U, Yürümez Y, Yaylacı S, et al. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras. 2020;66(8):1122-1127.
  • 11. Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015;52(2):86-105.
  • 12. Henry BM, Benoit JL, Benoit S, Pulvino C, Berger BA, Olivera MHS, et al. Red blood cell distribution width (RDW) predicts COVID-19 severity: A prospective, observational study from the cincinnati SARS-CoV-2 emergency department cohort. Diagnostics (Basel). 2020;21;10(9):E618
  • 13. WHO. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: Interim guidance. Available at: https://apps.who.int/iris/bitstream/handle/10665/331446/ WHO-2019-nCoV-clinical-2020.4-eng.pdf?sequence=1&isAllowed=y . Accessed September 23, 2020.
  • 14. Gong J, Ou J, Qiu X, Jie Y, Chen Y, Yuan L, et al. A tool for early prediction of severe coronavirus disease 2019 (COVID-19): A multicenter study using the risk nomogram in Wuhan and Guangdong, China. Clin Infect Dis. 2020;28;71(15):833-840.
  • 15. Zheng Y, Zhang Y, Chi H, Chen S, Peng M, Luo L, et al. The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study. Clin Chem Lab Med. 2020;25;58(7):1106-1115.
  • 16. Skevaki C, Fragkou PC, Cheng C, Xie M, Renz H. Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus. J Infect. 2020;81(2):205-212.
  • 17. Topaz G, Kitay-Cohen Y, Peled L, Gharra W, Kaminer K, Eitan M, et al. The association between red cell distribution width and poor outcomes in hospitalized patients with influenza. J Crit Care. 2017;41:166-169.
  • 18. Braun E, Domany E, Kenig Y, Mazor Y, Makhoul BF, Azzam ZS. Elevated red cell distribution width predicts poor outcome in young patients with community acquired pneumonia. Crit Care. 2011;11;15(4):R194.
  • 19. Kim CH, Park JT, Kim EJ, Han JH, Han JS, Choi JY, et al. An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock. Critical Care 2013;17:R282.
  • 20. Pourbagheri-Sigaroodi A, Bashash D, Fateh F, Abolghasemi H. Laboratory findings in COVID-19 diagnosis and prognosis. Clin Chim Acta. 2020 Aug 14;510:475-482.
  • 21. Semba RD, Patel KV, Ferrucci L, Sun K, Roy CN, Guralnik JM, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women’s Health and Aging Study I. Clin Nutr. 2010;29(5):600-4.
  • 22. Scharte M, Fink MP. Red blood cell physiology in critical illness. Crit Care Med. 2003;31(12 Suppl):S651-7.
  • 23. Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB. Red cell distribution width and all-cause mortality in critically ill patients. Crit Care Med. 2011;39(8):1913-21.
  • 24. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A metaanalysis. Clin Chim Acta. 2020;506:145-148.
  • 25. Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S, Cengiz AB, Ceyhan M. The value of mean platelet volume in the determination of community acquired pneumonia in children. Ital J Pediatr. 2013;8;39:16.
  • 26. Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A. The role of biomarkers in diagnosis of COVID-19 - A systematic review. Life Sci. 2020;1;254:117788.
  • 27. Bao C, Tao X, Cui W, Yi B, Pan T, Young KH, et al. W. SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients. Exp Hematol Oncol. 2020;17;9:16.
  • 28. Hottz ED, Bozza FA, Bozza PT. platelets in immune response to virus and immunopathology of viral infections. Front Med (Lausanne). 2018;30;5:121.
  • 29. Salamanna F, Maglio M, Landini MP, Fini M. Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (COVID-19). Platelets. 2020;3;31(5):627-632.

Ayrıntılar

Birincil Dil İngilizce
Konular Tıp
Bölüm ORIGINAL ARTICLE
Yazarlar

Mehmet Ali CEYHAN (Sorumlu Yazar)
Health Sciences University, Ankara City Hospital, Department of Emergency Medicine
0000-0003-0000-0177
Türkiye


Miray TÜMER
Ankara City Hospital, Department of Emergency Medicine
0000-0002-3917-0213
Türkiye


Selahattin GÜRÜ
Ankara City Hospital, Department of Emergency Medicine
0000-0002-0299-1691
Türkiye


Gültekin KADI
Ankara City Hospital, Department of Emergency Medicine
0000-0002-9195-6635
Türkiye


Gültekin Günhan DEMİR
Istanbul Medipol University Medical Faculty, Department of Cardiology
0000-0001-9975-5507
Türkiye

Yayımlanma Tarihi 5 Mayıs 2021
Başvuru Tarihi 12 Ocak 2021
Kabul Tarihi 10 Nisan 2021
Yayınlandığı Sayı Yıl 2021, Cilt 2, Sayı 2

Kaynak Göster

APA Ceyhan, M. A. , Tümer, M. , Gürü, S. , Kadı, G. & Demir, G. G. (2021). Mean Platelet Volume and Red Cell Distribution Width Values in Patients with COVID-19 Admitted to Intensive Care Units or Wards from Emergency Department . Archives of Current Medical Research , 2 (2) , 88-92 . DOI: 10.47482/acmr.2021.20

Archives of Current Medical Research (ACMR) provides instant open access to all content, bearing in mind the fact that presenting research

free to the public supports a greater global exchange of knowledge.

http://www.acmronline.org/