Retrospective investigation of the relationship between clinical and laboratory parameters and allergy tests in children with allergic rhinitis

Yıl 2023, Cilt: 4 Sayı: 3, 146 - 152, 27.09.2023

Ugur Altas , Eray Tunce , Zeynep Meva Altaş , Fatih Çiçek , Mehmet Yaşar Özkars

https://doi.org/10.47482/acmr.1309737

Cited By: 2

Öz

Background: It was aimed to investigate the relationship between neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), eosinophil-lymphocyte ratio (ELR), serum total immunoglobulin E (IgE) values and allergy test positivity in patients with allergic rhinitis (AR).
Methods: The study is a descriptive study with a retrospective design. Data on patients aged 0-18 years with a diagnosis of AR were investigated retrospectively. Age, gender, hemogram parameters (leukocyte, eosinophil, lymphocyte, thrombocyte), total IgE values, allergy history and allergy test positivity were evaluated. A p value of less than 0.05 was considered as a statistically significant result.
Results: In the study, the data of 230 pediatric patients with AR were analyzed. The median age of the children was 13 years (10-18). Of the patients 57.4% (n=132) were male, 42.6% (n=98) were female. All laboratory values, except PLR, of the patients with positive allergy test were higher than the patients with negative allergy test. This elevation in WBC, neutrophil, absolute eosinophil, eosinophil percentage, total IgE and ELR values was statistically significant (p<0.05). When the cut-off point for ELR is 0.066; sensitivity was 78.8% and specificity was 70.4%. When the cut-off point for total IgE is 134.5; sensitivity was 75.8%, specificity was 74.1% (p<0.001)
Conclusions: According to study results, 3 out of every 4 patients with positive allergy test can be detected by ELR and total IgE values. Since allergy tests cannot be performed in every clinics, it is extremely important to evaluate the success of more practical and accessible blood tests in predicting allergy test positivity.

Anahtar Kelimeler

Allergic rhinitis, children, allergy test, laboratory parameters.

Kaynakça

• Liva GA, Karatzanis AD, Prokopakis EP. Review of rhinitis: classification, types, pathophysiology. J Clin Med. 2021;10(14):3183.
• Tenero L, Vaia R, Ferrante G, Maule M, Venditto L, Piacentini G, et al. Diagnosis and management of allergic rhinitis in asthmatic children. J Asthma Allergy. 2023;16:45-57.
• Meltzer EO. Allergic rhinitis. Burden of illness, quality of life, comorbidities, and control. Immunol Allergy Clin North Am. 2016;36(2):235–248.
• Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001;108(1 Suppl):S2–8.
• Marple BF. Allergic rhinitis and inflammatory airway disease: interactions within the unified airspace. Am J Rhinol Allergy. 2010;24:249–254.
• Borish L. Allergic rhinitis: systemic inflammation and implications for management. J Allergy Clin Immunol. 2003;112(6):1021-31.
• Gelfand EW. Inflammatory mediators in allergic rhinitis. J Allergy Clin Immunol. 2004;114(5):S135-S8.
• Özdin M. Atopik dermatiti olan çocuklarda hematolojik ve alerjik değerler arasındaki ilişki. Balıkesir Medical Journal. 2020;4(3):1-6.
• Chen Y, Yang M, Deng J, Wang K, Shi J, Sun Y. Elevated levels of activated and pathogenic eosinophils characterize moderate-severe house dust mite allergic rhinitis. J Immunol Res. 2020;2020:8085615.
• Arebro J, Ekstedt S, Hjalmarsson E, Winqvist O, Kumlien Georén S, Cardell L-O. A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification. Sci Rep. 2017;7(1):43568.
• Page C, Pitchford S. Platelets and allergic inflammation. Clin Exp Allergy. 2014;44(7):901-13.
• Kant A, Terzioğlu K. Association of severity of allergic rhinitis with neutrophil-to-lymphocyte, eosinophil-to-neutrophil, and eosinophilto- lymphocyte ratios in adults. Allergol Immunopathol. 2021;49(5):94- 9.
• Çoban Ağca M, Aksoy E, Duman D, Özmen İ, Yıldırım E, Güngör S, et al. Does eosinophilia and neutrophil to lymphocyte ratio affect hospital readmission in cases of COPD exacerbation? Tuberk Toraks. 2017;65(4):282–90.
• Dogru M, Evcimik MF, Cirik AA. Is neutrophil–lymphocyte ratio associated with the severity of allergic rhinitis in children? Eur Arch Otorhinolaryngol. 2016;273:3175-8.
• Dinçer Z, Özkars M. Allerjik rinit hastalarımızda alerji testleri. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi.14(2):49-51.
• Bousquet J, Van Cauwenberge P, Khaltaev N, Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108 (5 Suppl):S147-334.
• Topal E, Çatal F, Ermiştekin H, Özdemir R, Karadağ A, Sinanoğlu MS, et al. Malatya yöresinde astım ve alerjik rinit tanısı konulan çocukların deri prik testlerindeki aeroalerjen dağılımları. Abant Tıp Dergisi. 2014;3(3):215-9.
• Lee J-E, Ahn J-C, Han DH, Kim D-Y, Kim J-W, Cho S-H, et al. Variability of offending allergens of allergic rhinitis according to age: optimization of skin prick test allergens. Allergy Asthma Immunol Res. 2014;6(1):47-54.
• Küçükosmanoğlu E, Tanıdır C, Demir F, Coşkun Ş, Hafızoğlu T, Şeşeoğulları Y, et al. İstanbul’da çocuklarda solunum allerjenleri duyarlılığı. Gaziantep Medical Journal. 2009;15(3):10-3.
• İğde FA, Sancak R, Öztürk F. Orta karadeniz bölgesindeki çocuklarda allerji deri testi sonuçları. Turkiye Klinikleri J Pediatr. 2009;18:82-90.
• Koca H. Osmaniye yöresinde allerjik solunum yolu şikayetleriyle başvuran hastalarda uygulanan deri prick test sonuçlarının değerlendirilmesi. İzmir Göğüs Hastanesi Dergisi. 2013;27:159-64.
• Yenigun A, Sezen S, Calim OF, Ozturan O. Evaluation of the eosinophil-to-lymphocyte ratio in pediatric patients with allergic rhinitis. Am J Rhinol Allergy. 2016;30:21–5.
• Chawes BLK, Bønnelykke K, Kreiner-Møller E, Bisgaard H. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol. 2010;126(3):567-73. e8.
• Wang J, Zhou Y, Zhang H, Hu L, Liu J, Wang L, et al. Pathogenesis of allergic diseases and implications for therapeutic interventions. Signal Transduct Target Ther. 2023;8(1):138.
• Jung YG, Kim KH, Kim HY, Dhong HJ, Chung SK. Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma. J Int Med Res. 2011;39:2209–16.
• Ekici NY. Is there any correlation between allergy and hematological parameters in children with allergic rhinitis? Kocaeli Med J. 2019;8:29– 34.