Diferansiye tiroid kanseri nüksünün açıklanabilir yapay zeka modeli ile tahmin edilmesi

Yıl 2025, Cilt: 6 Sayı: 3, 280 - 287, 28.09.2025

Ahmet Cankat Öztürk , Erkan Akkur , Serkan Çizmecioğullari

https://doi.org/10.47482/acmr.1677545

Öz

Amaç: Bu çalışmanın amacı, diferansiye tiroid kanserinin nüksünü tahmin etmek ve açıklanabilir yapay zeka modeli aracılığıyla nüksün en temsili özelliklerini belirlemektir.
Gereç ve yöntemler: Veri kümesi UCI Makine Öğrenimi Deposundan elde edilmiş ve “Diferansiye Tiroid Kanseri Nüksü” olarak adlandırılmıştır. Bu veri kümesi 383 hasta ve 17 özellik içermektedir. Diferansiye tiroid kanserinin nüksünü tahmin etmek için Random Forest, Gradient Boosting, AdaBoost, Support Vector Classifier ve Logistic Regression olmak üzere beş sınıflandırıcı kullanılmıştır. Tahmin sonucu üzerinde en fazla etkiye sahip özellikleri belirlemek için permütasyon özellik önemi ve Shapley açıklanabilir yapay zeka yöntemleri kullanılmıştır.
Sonuçlar: Random Forest algoritması sırasıyla %0,9739 ve 0,993 ile en yüksek doğruluk ve AUC-ROC skorunu elde etmiştir. En belirgin risk faktörleri tedavi yanıtı, ATA riski, tümör ve yaş olarak belirlenmiştir.
Sonuç: Önerilen açıklanabilir makine öğrenimi modeli, diferansiye tiroid kanserinin nüksünü tahmin etmek ve en belirgin özellikleri belirlemek için güvenilir bir model olarak kabul edilebilir. Bu model, sağlık profesyonellerine yardımcı olma potansiyeline sahip olabilir.

Anahtar Kelimeler

Diferansiye tiroid kanseri , nüks , makine öğrenmesi , açıklanabilir yapay zeka , shapley , permütasyon özellik önemi

Predicting recurrence of differentiated thyroid cancer with an explainable artificial intelligence model

Öz

Background: This study aimed to predict the recurrence of differentiated thyroid cancer and identify its most representative risk factors using an explainable artificial intelligence model.
Methods: The publicly available Differentiated Thyroid Cancer Recurrence dataset from the University of California Irvine Machine Learning Repository, comprising 383 patients and 17 features, was employed. Five classifiers, -Random Forest, Gradient Boosting, AdaBoost, Support Vector Classifier and Logistic Regression-, were employed to predict the recurrence. Permutation feature importance (PFI) and SHapley Additive exPlanations (SHAP) explainable artificial intelligence methods were used to determine the features that had the most impact on the prediction result.
Results: The Random Forest algorithm outperformed others, achieving an accuracy of 97.39% and an Area under the Curve of 0.993. Response to treatment, ATA risk stratification, tumor stage and patient age were determined as the factors with the highest contribution to the model prediction process through SHAP and permutation importance analyses, and this finding was consistent with the prognostic markers stated in the literature.
Conclusion: The proposed explainable machine learning framework has shown satisfactory results in predicting DTC recurrence while identifying clinically important features. This approach can offer valuable support to clinicians in early identification of high-risk patients and personalization of surveillance strategies.

Anahtar Kelimeler

Differentiated thyroid cancer , recurrence , machine learning , explainable artificial intelligence , shapley , permutation feature importance

Kaynakça

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