Novel treatment strategies in cancer immunotherapy

Yıl 2017, Cilt 30, Sayı 2, 36 - 51, 30.06.2018

Cenk Serhan OZVEREL İsmail KARABOZ Ayse NALBANTSOY

Öz

Immune system has gained importance in research especially in cancer treatment studies which is also regarded as cancer immunotherapy. Cancers are the leading causes of death in the world, yet there is no effective therapeutics found against them. Current treatment strategies are found to be insufficient and non-specific. Recent studies showed that, for an effective cancer therapy, host immune system needs to be activated. Research on cancer and tumor microenvironment provided more molecular information about cancer and immune cells. Immune based studies on cancer immunotherapy highlighted the importance of host immune system on cancer eradication. One of the first immunotherapeutic used against cancer cells are trastuzumab which is a monoclonal antibody targeting Epidermal Growth Factor Receptor (EGFR). Although, it is regarded as a huge milestone in cancer immunotherapy, it is found to be insufficient in treatment. In this review, recent advances in both active and passive immunotherapies are going to be discussed including the obstacles in the treatment strategies and studies carried out to overcome them.

Anahtar Kelimeler

Immunotherapy, Cancer, Vaccine, mAb

Kaynakça

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