BibTex RIS Kaynak Göster

Analysis of Second Primary Lung Cancers Developed Following Different System Tumors

Yıl 2013, , 1 - 7, 01.04.2013
https://doi.org/10.5505/aot.2013.36844

Öz

OBJECTIVE: This study aimed to investigate clinical characteristics and prognosis of secondarily developed lung tumors in the cases having different system malignancy and to evaluate the relationship with the primary tumor.METHODS: Between January 2002- December 2010 thirty patients diagnosed as second primary lung cancer have been included in the study. The patients were grouped according to lung cancer development time; synchronous group (n: 7 patients, 16.7%) and metachronous group (n: 23 patients, 83.3%). RESULTS: Second cancer was detected in 50% of the patients within the first 2.5 years. Majority of patients had extra pulmonary cancer history concerning their relatives (43.3%). The rate of quitting smoking among all patients before the diagnosis of lung cancer was 50 %, current smoker rate was 30 % and never smoker was 20%. There was no statistical relationship between the response to treatment of first cancer and the duration of cancer developed secondarily (p=0.36). The overall survival of groups was found 24 months (95% confidence interval: 18.30 months) and 12 months (95% confidence interval: 10-14 months) respectively for synchronous and metachronous groups. CONCLUSION: Close follow-up on pulmonary system especially within the first 2.5 years after primary disease and encouragement on quitting smoking is important.

Kaynakça

  • Liu YY, Chen YM, Yen SH, Tsai CM, Perng RP. Multiple primary malignancies involving lung cancer-clinical characteristics and prognosis. Lung Cancer 2002;35:189-94
  • Watanabe S, Kodama T, Shimosato Y, et al. Multiple primary cancers in 5,456 autopsy cases in the National Cancer Center of Japan. J Natl Cancer Inst 1984;72:1021-7
  • Curtis RE, Boice JD Jr, Kleinerman RA, Flannery JT, Fraumeni JF Jr. Multiple primary cancers in Connecticut 1985;68:219-42 NCI Monogr
  • Levi F, Randimbison L, Te VC, La Vecchia C. Second primary cancers in patients with lung carcinoma. Cancer 1999;86:186-90
  • Holland JM, Arsanjani A, Liem BJ, Hoffelt SC, Cohen JI, Stevens KR Jr. Second malignancies in early stage laryngeal carcinoma patients treated with radiotherapy. Journal of Laryngology & Otology 2002;1163:190-3
  • Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-47
  • Hsu YB, Chang SY, Lan MC, Huang JL, Tai SK, Chu PY. Second primary malignancies in squamous cell carcinomas of the tongue and larynx: an analysis of incidence, pattern, and outcome. J Chin Med Assoc 2008;71:86-91
  • Behrens C, Travis LB, Wistuba II, et al. Molecular changes in second primary lung and breast cancers after therapy for Hodgkin’s Disease. Cancer Epidemiology, 2000;9:1027-35 and Prevention
  • Atienza JA, Dasanu CA. Incidence of second primary malignancies in patients with treated head and neck cancer: a comprehensive review of literature. Curr Med Res Opin 2012;28:1899-909
  • Chuang SC, Scelo G, Tonita JM, et al. Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries. Int J Cancer 2008;123:2390
  • Morris LG, Sikora AG, Patel SG, Hayes RB, Ganly I. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol 2011;29:739
  • Lorigan P, Radford J, Howell A, Thatcher N. Lung cancer after treatment for Hodgkin's lymphoma: a systematic review. Lancet Oncol 2005;6:773
  • Kaufman EL, Jacobson JS, Hershman DL, Desai M, Neugut AI. Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer. Journal of Clinical Oncology 2008;26:392-8
  • Swerdlow AJ, Douglas AJ, Hudson GV, Hudson BV, Bennett MH, MacLennan KA. Risk of second primary cancers after Hodgkin's disease by type of treatment: analysis of 2846 patients in the British National 1992;304:1137 Investigation. BMJ
  • Travis LB, Fosså SD, Schonfeld SJ, et al. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005;97:1354
  • Nandy N, Dasanu CA. Incidence of second primary malignancies in patients with esophageal cancer: a comprehensive review. Curr Med Res Opin 2013;29:1055-65
  • Geurts TW, Nederlof PM, van den Brekel MW, et al. Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: Metastasis or second 2005;11:6608-14 Cancer Research
  • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium. Cancer 1953;6:963-8
  • Carey T. Field cancerization: are multiple primaries monoclonal or polyclonal? Ann Med 1996;28:183-8
  • Parsons A, Daley A, Begh R, Aveyard P. Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta- analysis. BMJ 2010;340:b5569
  • Li X, Hemminki K. Familial and second lung cancers: a nation- wide epidemiologic study from Sweden. Lung Cancer 2003;39:255-63
  • Tan L, Greener CC, Seikaly H, Rassekh CH, Calhoun KH. Role of screening chest computed tomography in patients with advanced head and neck cancer.
  • Otolaryngology 1999;120:689-92

Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi

Yıl 2013, , 1 - 7, 01.04.2013
https://doi.org/10.5505/aot.2013.36844

Öz

AMAÇ: Bu çalışmada farklı sistem malignitelerine sekonder olarak gelişen akciğer tümörlerin klinik özellikleri ve primer tümörle olan ilişkilerinin araştırılması amaçlandı.YÖNTEMLER: 2002-2010 yılları arasında takipleri sırasında ikinci primer kanser tanısı alan otuz hasta çalışmaya dahil edildi. Hastalar, akciğer kanseri gelişme sürelerine göre senkron (n: 7 hasta, %16,7)ve metakron (N.23 Hasta, %83,3) grup olarak iki grupta değerlendirildi.BULGULAR: Hastaların %50sinde ilk 2.5 yıl içinde ikinci primer kanser saptandı. Hastaların çoğunluğunun (%43.3) akrabalarında ekstra pulmoner kanser öyküsü vardı. Akciğer kanseri tanısı konulan hastalardan %50sinde sigarayı bırakma, %30unda aktif içici ve %20sinde hiç sigara kullanmamış olma öyküsü vardı. Primer kanser ile ilgili yapılan tedaviye yanıt ve ikincil gelişen kanserin süresi arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (p=0.36).Grupların tamamında sağ kalım süresi 24 ay senkron grupta, 12 ay metakron grupta belirlendi.SONUÇ: Primer hastalıktan sonra özellikle ilk 2.5 yıl içinde yakın takip ve hastalara sigara içiciliğinin bıraktırılmasının teşvik edilmesi önem taşımaktadır.

Kaynakça

  • Liu YY, Chen YM, Yen SH, Tsai CM, Perng RP. Multiple primary malignancies involving lung cancer-clinical characteristics and prognosis. Lung Cancer 2002;35:189-94
  • Watanabe S, Kodama T, Shimosato Y, et al. Multiple primary cancers in 5,456 autopsy cases in the National Cancer Center of Japan. J Natl Cancer Inst 1984;72:1021-7
  • Curtis RE, Boice JD Jr, Kleinerman RA, Flannery JT, Fraumeni JF Jr. Multiple primary cancers in Connecticut 1985;68:219-42 NCI Monogr
  • Levi F, Randimbison L, Te VC, La Vecchia C. Second primary cancers in patients with lung carcinoma. Cancer 1999;86:186-90
  • Holland JM, Arsanjani A, Liem BJ, Hoffelt SC, Cohen JI, Stevens KR Jr. Second malignancies in early stage laryngeal carcinoma patients treated with radiotherapy. Journal of Laryngology & Otology 2002;1163:190-3
  • Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-47
  • Hsu YB, Chang SY, Lan MC, Huang JL, Tai SK, Chu PY. Second primary malignancies in squamous cell carcinomas of the tongue and larynx: an analysis of incidence, pattern, and outcome. J Chin Med Assoc 2008;71:86-91
  • Behrens C, Travis LB, Wistuba II, et al. Molecular changes in second primary lung and breast cancers after therapy for Hodgkin’s Disease. Cancer Epidemiology, 2000;9:1027-35 and Prevention
  • Atienza JA, Dasanu CA. Incidence of second primary malignancies in patients with treated head and neck cancer: a comprehensive review of literature. Curr Med Res Opin 2012;28:1899-909
  • Chuang SC, Scelo G, Tonita JM, et al. Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries. Int J Cancer 2008;123:2390
  • Morris LG, Sikora AG, Patel SG, Hayes RB, Ganly I. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol 2011;29:739
  • Lorigan P, Radford J, Howell A, Thatcher N. Lung cancer after treatment for Hodgkin's lymphoma: a systematic review. Lancet Oncol 2005;6:773
  • Kaufman EL, Jacobson JS, Hershman DL, Desai M, Neugut AI. Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer. Journal of Clinical Oncology 2008;26:392-8
  • Swerdlow AJ, Douglas AJ, Hudson GV, Hudson BV, Bennett MH, MacLennan KA. Risk of second primary cancers after Hodgkin's disease by type of treatment: analysis of 2846 patients in the British National 1992;304:1137 Investigation. BMJ
  • Travis LB, Fosså SD, Schonfeld SJ, et al. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005;97:1354
  • Nandy N, Dasanu CA. Incidence of second primary malignancies in patients with esophageal cancer: a comprehensive review. Curr Med Res Opin 2013;29:1055-65
  • Geurts TW, Nederlof PM, van den Brekel MW, et al. Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: Metastasis or second 2005;11:6608-14 Cancer Research
  • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium. Cancer 1953;6:963-8
  • Carey T. Field cancerization: are multiple primaries monoclonal or polyclonal? Ann Med 1996;28:183-8
  • Parsons A, Daley A, Begh R, Aveyard P. Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta- analysis. BMJ 2010;340:b5569
  • Li X, Hemminki K. Familial and second lung cancers: a nation- wide epidemiologic study from Sweden. Lung Cancer 2003;39:255-63
  • Tan L, Greener CC, Seikaly H, Rassekh CH, Calhoun KH. Role of screening chest computed tomography in patients with advanced head and neck cancer.
  • Otolaryngology 1999;120:689-92
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Çiğdem Özdilekcan Bu kişi benim

Sevim Turanlı Bu kişi benim

Necla Songür Bu kişi benim

Hüseyin Çakmak Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2013
Yayımlandığı Sayı Yıl 2013

Kaynak Göster

APA Özdilekcan, Ç. ., Turanlı, S. ., Songür, N. ., Çakmak, H. . (2013). Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi. Acta Oncologica Turcica, 46(1), 1-7. https://doi.org/10.5505/aot.2013.36844
AMA Özdilekcan Ç, Turanlı S, Songür N, Çakmak H. Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi. Acta Oncologica Turcica. Nisan 2013;46(1):1-7. doi:10.5505/aot.2013.36844
Chicago Özdilekcan, Çiğdem, Sevim Turanlı, Necla Songür, ve Hüseyin Çakmak. “Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi”. Acta Oncologica Turcica 46, sy. 1 (Nisan 2013): 1-7. https://doi.org/10.5505/aot.2013.36844.
EndNote Özdilekcan Ç, Turanlı S, Songür N, Çakmak H (01 Nisan 2013) Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi. Acta Oncologica Turcica 46 1 1–7.
IEEE Ç. . Özdilekcan, S. . Turanlı, N. . Songür, ve H. . Çakmak, “Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi”, Acta Oncologica Turcica, c. 46, sy. 1, ss. 1–7, 2013, doi: 10.5505/aot.2013.36844.
ISNAD Özdilekcan, Çiğdem vd. “Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi”. Acta Oncologica Turcica 46/1 (Nisan 2013), 1-7. https://doi.org/10.5505/aot.2013.36844.
JAMA Özdilekcan Ç, Turanlı S, Songür N, Çakmak H. Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi. Acta Oncologica Turcica. 2013;46:1–7.
MLA Özdilekcan, Çiğdem vd. “Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi”. Acta Oncologica Turcica, c. 46, sy. 1, 2013, ss. 1-7, doi:10.5505/aot.2013.36844.
Vancouver Özdilekcan Ç, Turanlı S, Songür N, Çakmak H. Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi. Acta Oncologica Turcica. 2013;46(1):1-7.