Öz
Background: Adenoid cystic carcinoma (ACC), one of the rarest neoplasia of the breast, constitutes 0.1% of all breast carcinomas. The prognosis of ACC is very good compared to other histological subtypes of breast carcinoma. Lymph node involvement and distant metastasis are very infrequent. Estrogen receptor (ER), progesterone receptor (PR) and c-erbB2 (also known as HER-2/neu) are typically negative.CaseA fourty eight year-old premenauposal women was admitted to hospital with a mass on the upper outer quadrant of her left breast. Since the result of through-cut biopsy of this suspicious lesion was consistent with adenoid cystic carcinoma, modified radical mastectomy with axillary lymph node excision was applied. Pathological examination revealed a moderately differantiated adenoid cystic carcinoma of the breast. The size of invasive tumor component was 4.8 cm in its greatest dimension. Immunohistochemical analysis was consistent with triple negative phenotype ( ER,PR and c-erbB2 negative).Conclusion: ACC is a rare type of human breast carcinoma with ER, PR and c-erbB2 negative phenotype. They usually show an excellent prognosis however there is no well defined treatment options for ACC since the rarity of clinical studies in such kind of unusual histological subtypes of breast carcinomas.
Anahtar Kelimeler
Kaynakça
- Sumpio BE, Jennings TA, Merino MJ, Sullivan PD. Adenoid cystic carcinoma of the breast: Data from the Connecticut tumor registry and a review of the literature. Ann Surg. 1987;205:295-301
- Arpino G, Clark GM, Mohsin S, Bardou VJ, Elledge RM. Adenoid cystic carcinoma of the breast: molecular markers, treatment, and clinical outcome. Cancer 2002;94:2119-27
- McClenathan JH, de la Roza G. Adenoid cystic breast cancer. Am J Surg 2002;183:646-9
- Billroth T: Die Cylindergeschwalst. Untersuchungen
- ueber die Entwicklung der Blutgefefasse. Berlin: G Reimer; 1856:55-69
- Page DL. Adenoid cystic carcinoma of breast, a special histopathologic type with excellent prognosis [comment]. Breast Cancer Res Treat 2005;93:189-90
- Azoulay S, Lae M, Freneaux P, et al. KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Mod Pathol 2005;18:1623-31
- Leeming R, Jenkins M, Mendelson G. Adenoid cystic carcinoma of the breast. Arch Surg 1992;127:233-5
- Ro JY, Silva EG, Gallager HS. Adenoid cystic carcinoma of the breast. Hum Pathol 1987;18:1276- 81
- McClenathan JH, de la Roza G. Adenoid cystic breast cancer. Am J Surg. 2002;183:646-9
- JH, Kim MJ, Kim EK, Lee JY, Oh KK, Park BW. Recurrence of adenoid cystic carcinoma in the breast after lumpectomy and adjuvant therapy. J Ultrasound Med 2006;25:921-4
Öz
Giriş: Adenoid kistik karsinom (ACC), memenin nadir görülen neoplazmlarındandır. Tüm meme karsinomlarının %0.1'ini oluşturmaktadır.Adenoid kistik karsinomlar memede izlenen diğer histolojik alt tiplerine göre çok iyi prognoza sahiptirler.Uzak metastaz ve lenf nodu tutulumu çok nadirdir. Sıklıkla östrojen reseptörü (ER), progesteron reptörü(PR) ve cerbB2 statusu negatif olarak tespit edilmektedir.Olgu: Kırksekiz yaşında premenapozal kadın hasta sol memede ele gelen kitle nedeniyle doktora başvurmuş. Hastaya memedeki lezyon için through-cut biyopsi uygulandı. Biyopsi sonucunun adenoid kistik karsinom olarak gelmesi üzerine hastaya modifiye radikal mastektomi operasyonu uygulandı. Operasyon materyalinin patolojik incelemesi orta derecede diferansiye adenoid kistik karsinoma ile uyumlu olarak tespit edildi. Tümör boyutu 4.8 cm ve aksiller diseksiyon sonucu 48 lenf nodu negatif olarak tespit edildi. Tümörün immünohistokimyasal özellikleri triple negatif (ER, PR ve c-erbB2) olarak değerlendirildi.Sonuç: ACC'ler çoğunlukla ER(-),PR (-) ve CERBB2(-) hormon statusu ile ender görülen meme karsinomlarıdır.ACC'ler nadir görülen meme karsinomları olduğundan ve yeterli klinik çalışma bulunmadığından tedavi opsiyonları sınırlıdır.
Anahtar Kelimeler
Kaynakça
- Sumpio BE, Jennings TA, Merino MJ, Sullivan PD. Adenoid cystic carcinoma of the breast: Data from the Connecticut tumor registry and a review of the literature. Ann Surg. 1987;205:295-301
- Arpino G, Clark GM, Mohsin S, Bardou VJ, Elledge RM. Adenoid cystic carcinoma of the breast: molecular markers, treatment, and clinical outcome. Cancer 2002;94:2119-27
- McClenathan JH, de la Roza G. Adenoid cystic breast cancer. Am J Surg 2002;183:646-9
- Billroth T: Die Cylindergeschwalst. Untersuchungen
- ueber die Entwicklung der Blutgefefasse. Berlin: G Reimer; 1856:55-69
- Page DL. Adenoid cystic carcinoma of breast, a special histopathologic type with excellent prognosis [comment]. Breast Cancer Res Treat 2005;93:189-90
- Azoulay S, Lae M, Freneaux P, et al. KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Mod Pathol 2005;18:1623-31
- Leeming R, Jenkins M, Mendelson G. Adenoid cystic carcinoma of the breast. Arch Surg 1992;127:233-5
- Ro JY, Silva EG, Gallager HS. Adenoid cystic carcinoma of the breast. Hum Pathol 1987;18:1276- 81
- McClenathan JH, de la Roza G. Adenoid cystic breast cancer. Am J Surg. 2002;183:646-9
- JH, Kim MJ, Kim EK, Lee JY, Oh KK, Park BW. Recurrence of adenoid cystic carcinoma in the breast after lumpectomy and adjuvant therapy. J Ultrasound Med 2006;25:921-4
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Nisan 2013 |
| Yayımlandığı Sayı | Yıl 2013 |