Valproik Asit Kullanımına Bağlı Fetal Ouadrigeminal Araknoid Kist

Yıl 2006, Cilt: 39 Sayı: 2, 114 - 116, 01.08.2006

Gülşah Bayram Kabaçam Z. Nilgün Yildirim Özbay Bige Sayın Perihan Soydinç Doğan Dede

Öz

Valproic acid (VPA) is a commonly used antiepileptic drug, that is well known to be a potent teratogen. Especially, its use in the 8 weeks of pregnancy increases this teratogenic potential. Among these anomalies caused by VPA are many forms of syste-mic involvement and craniofacial anomalies, however there was no case of arachnoid cyst. Here, we present a case of fetal arachnoid cyst in an epileptic pregnant vvomen who used VPA which is the most probable reason for this teratogenic effect, to draw attention to teratogenic spectrum of VPA.

Anahtar Kelimeler

Thymoma, Second malignaney.

Fetal Ouadrigeminal Arachnoid Cyst Secondary to Usage of Valproic Acid

Öz

Valproik asit (VPA), sıkça kullanılan, oldukça teratojen olduğu bilinen bir antiepileptik ilaçtır. Özellikle gebeliğin ilk 8 haftasında kullanımıyla teratojenik etkisinin arttığı bilinmektedir. Fetusta oluşan anomaliler arasında birçok sistemik tutulum ve kra-niofasial anomaliler bildirilmiş olmakla beraber daha önce literatürde bildirilen kraniofasial anomaliler arasında araknoid kiste rastlanmamaktadır. Gebeliğinin ilk 8 haftasında VPA kullanmış olan epileptik gebede izlediğimiz fetal araknoid kistin bu antiepi-leptiğin kullanımına bağlı olabileceğini düşünerek, VPA'nın teratojenik spektrumunun bilinenden daha geniş olabileceğini tartışmak amacıyla vakayı sunuyoruz.

Anahtar Kelimeler

Timoma, ikincil malignite.

Kaynakça

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